Patent US4364861A successfully refreshed from Google Patents.
US4364861A
Expired / Lapsed
US
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Blood-coagulation-promoting products and methods of preparing them
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1980-05-27
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Granted: 1982-12-21
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Expires: 2000-05-27
Abstract
Abstract Blood-coagulation-promoting products substantially free of thrombin are prepared from human blood plasma by contacting a human blood plasma fraction containing coagulation Factors II, VII, IX and X with an anion exchanger to adsorb the coagulation Factors, which are subsequently eluted from the anion exchanger. The eluate is treated to generate a substance having Factor VIII Inhibitor Bypassing Activity and being substantially free of thrombin, and activated Factor X.
Inventors
- 👤 Gautam Mitra
- 👤 Michael H. Coan
- 👤 Shohachi Wada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:26
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/647; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
68 words
A pharmaceutical preparation free of heparin, comprising coagulation Factors II, VII, IX, and X and having Factor VIII Inhibitor Bypassing Activity (FEIB-activity) wherein the FEIBA:Factor II ratio, the FEIBA:Factor VII ratio, the FEIBA:Factor IX ratio, and the FEIBA:Factor X ratio, are about 10:1 to 0.1:1, respectively, and wherein the FEIBA:activity is at least about 60 Units per milliliter and wherein the FEIBA:thrombin ratio is at least about 50:1.
Claim 2
Dependent Claim
68 words
A pharmaceutical preparation free of heparin, comprising coagulation Factors II, VII, IX, and X and having Factor VIII Inhibitor Bypassing Activity (FEIB-activity) wherein the FEIBA:Factor II ratio, the FEIBA:Factor VII ratio, the FEIBA:Factor IX ratio, and the FEIBA:Factor X ratio, are about 10:1 to 0.1:1, respectively, and wherein the FEIBA:activity is at least about 60 Units per milliliter and wherein the FEIBA:thrombin ratio is at least about 50:1.
Claim 3
Dependent Claim
15 words
The preparation of claim 1 wherein the FEIBA:Factor Xa ratio is at least about 45:1.
Claim 4
Dependent Claim
43 words
The preparation of claim 1 wherein the FEIBA:Factor II ratio is about 1.5:1 to 6:1, the FEIBA:Factor VII ratio is about 0.5:1 to 1.5:1, the FEIBA:Factor IX ratio is about 1:1 to 2:1, and the FEIBA:Factor X ratio is about 1.5:1 to 7:1.
Claim 5
Dependent Claim
16 words
The preparation of claim 1 which contains less than 1.5 Units per millilter of thrombin activity.
Claim 6
Dependent Claim
24 words
The preparation of claim 1 which contains less than 0.5 Units per milliliter of thrombin and the FEIBA:thrombin ratio is about 1000:1 or higher.
Claim 7
Dependent Claim
63 words
A pharmaceutical preparation free of detectable thrombin and heparin, comprising coagulation Factors II, VII, IX, and X and having Factor VIII Inhibitor Bypassing Activity (FEIB-activity) wherein the FEIBA:Factor II ratio is about 1.5:1 to 6:1, the FEIBA:Factor VII ratio is about 0.5:1 to 1.5:1, the FEIBA:Factor IX ratio is about 1:1 to 2:1, and the FEIBA:Factor X ratio is about 1.5:1 to 7:1.
Claim 8
Dependent Claim
63 words
A pharmaceutical preparation free of detectable thrombin and heparin, comprising coagulation Factors II, VII, IX, and X and having Factor VIII Inhibitor Bypassing Activity (FEIB-activity) wherein the FEIBA:Factor II ratio is about 1.5:1 to 6:1, the FEIBA:Factor VII ratio is about 0.5:1 to 1.5:1, the FEIBA:Factor IX ratio is about 1:1 to 2:1, and the FEIBA:Factor X ratio is about 1.5:1 to 7:1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-20 | 1986-06-21 | 1986-12-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-20 | 1990-06-21 | 1990-12-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-20 | 1994-06-21 | 1994-12-21 | $7700.00 | Window Closed / Lapsed |