US4361552A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Wound dressing
Assignee: The University of Texas System
•
Filing: 1980-09-26
•
Granted: 1982-11-30
•
Expires: 2000-09-26
Abstract
Abstract A method of treating a wound or burn which comprises covering the surface of the wound or burn with a cross-linked amnion dressing.
Inventors
- 👤 Paul S. Baur, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:26
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/128; A61; A61L; A61L15/00; A61L15/16; A61L15/40
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
31 words
A method of treating a wound or burn comprising the covering of said wound or burn with a dressing formed of amnion in which the proteins have been fixed by cross-linking.
Claim 2
Independent Claim
31 words
A method of treating a wound or burn comprising the covering of said wound or burn with a dressing formed of amnion in which the proteins have been fixed by cross-linking.
Claim 3
Dependent Claim
27 words
The method of claim 1 in which said amnion dressing is formed by stabilizing the proteins of the amnion with a solution containing a chemical cross-linking agent.
Claim 4
Dependent Claim
37 words
The method of claim 2 in which said chemical cross-linking agent is selected from one or more of the group consisting of glyoxal, glutaraldehye, hydroxyadipaldehyde, pyruvic aldehyde, crotonaldehyde, acetaldehyde, acrolein, methacrolein, formaldehyde, malonaldehyde, succinaldehyde and chromic acid.
Claim 5
Dependent Claim
22 words
The method of claim 2 in which the concentration of said chemical cross-linking agent in said solution is from 0.001% to 25%.
Claim 6
Dependent Claim
24 words
The method of claim 4 in which said amnion is fixed in said solution for a period of from two hours to four weeks.
Claim 7
Dependent Claim
29 words
The method of claim 4 in which said solution is buffered with an osmolarity buffer so that said solution has an osmolarity of from 50 mOs to 2,000 mOs.
Claim 8
Dependent Claim
37 words
The method of claim 2 in which said cross-linked amnion is prepared for storage by storing in an antiseptic, saline or distilled water maintenance solution and maintained at a temperature of from 0° C. to 25° C.
Claim 9
Dependent Claim
36 words
The method of claim 7 in which said cross-linked amnion prepared for use by rinsing until the concentration of free chemical cross-linking agent from said maintenance solution is reduced to acceptable human tolerance in said amnion.
Claim 10
Dependent Claim
36 words
The method of claim 2 in which said cross-linked amnion is prepared for storage by rinsing until the concentration of said chemical cross-linking agent in said solution is reduced to acceptable human tolerance, air-drying and sterilizing.
Claim 11
Dependent Claim
22 words
The method of claim 9 in which said cross-linked amnion is dehydrated in an acceptable organic solvent prior to said air-drying thereof.
Claim 12
Dependent Claim
42 words
The method of claim 2 in which said cross-linked amnion is prepared for storage by rinsing until the concentration of said chemical cross-linking agent in said solution is reduced to acceptable human tolerance, subjecting said rinsed cross-linked amnion to lyophilization, and sterilizing.
Claim 13
Dependent Claim
37 words
A dressing for wounds, burns and surgically affected body members comprising amnion, the proteins of which have been cross-linked by fixing in a solution of a chemical cross-linking agent capable of cross-linking the proteins of said amnion.
Claim 14
Dependent Claim
37 words
A dressing for wounds, burns and surgically affected body members comprising amnion, the proteins of which have been cross-linked by fixing in a solution of a chemical cross-linking agent capable of cross-linking the proteins of said amnion.
Claim 15
Dependent Claim
42 words
A dressing as set forth in claim 12 in which said solution includes a chemical cross-linking agent selected from one or more of the group consisting of glyoxal, glutaraldehyde, hydroxyadipaldehyde, pyruvic aldehyde, crotonaldehyde, acetaldehyde, acrolein, methacrolein, formaldehyde, malonaldehyde, succinaldehyde and chromic acid.
Claim 16
Dependent Claim
25 words
A dressing as set forth in claim 12 in which the concentration of said chemical cross-linking agent in said solution is from 0.001% to 25%.
Claim 17
Dependent Claim
26 words
A dressing as set forth in claim 14 in which said amnion is fixed to said solution for a period of two hours to four weeks.
Claim 18
Dependent Claim
32 words
A dressing as set forth in claim 14 in which said solution is buffered with an osmolarity buffer so that said solution has an osmolarity of from 50 mOs to 2,000 mOs.
Claim 19
Dependent Claim
39 words
A dressing as set forth in claim 13 in which said cross-linking amnion is prepared for storage by storing in an antiseptic, saline or distilled water maintenance solution and maintained at a temperature of 0° C. to 25° C.
Claim 20
Dependent Claim
40 words
A dressing as set forth in claim 17 in which said cross-linked amnion is prepared for use by rinsing until the concentration of free chemical cross-linking agent from said maintenance solution is reduced to acceptable human tolerance in said amnion.
Claim 21
Dependent Claim
39 words
A dressing as set forth in claim 12 in which said cross-linked amnion is prepared for storage by rinsing until the concentration of said chemical cross-linking agent in said solution is reduced to acceptable human tolerance, air-drying and sterilizing.
Claim 22
Dependent Claim
25 words
A dressing as set forth in claim 19 in which said cross-linked amnion is dehydrated in an acceptable organic solvent prior to said air-drying thereof.
Claim 23
Dependent Claim
45 words
A dressing as set forth in claim 12 in which said cross-linked amnion is prepared for storage by rinsing until the concentration of said chemical cross-linking agent in said solution is reduced to acceptable human tolerance, subjecting said rinsed cross-linked amnion to lyophilization, and sterilizing.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |