Patent US4351844A successfully refreshed from Google Patents.
US4351844A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hypocholesterolemic hydrogenation products and process of preparation
Assignee: Merck and Co Inc
•
Filing: 1980-12-01
•
Granted: 1982-09-28
•
Expires: 2000-12-01
Abstract
Abstract Hydrogenation of the natural fermentation product, mevinolin, MK-803, results in the production of dihydro- and tetra-hydro derivatives and hydrogenation of the naturally occurring dihydromevinolin results in the formation of a tetrahydro derivative. These several products with the exception of cis-(4 alpha beta , 8 alpha beta -)-tetrahydromevinolin are potent inhibitors of cholesterol biosynthesis.
Inventors
- 👤 Arthur A. Patchett
- 👤 Chan-Hwa Kuo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:52
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/16; C07D309/28; C07D309/30
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
89 words
A compound of the formula: ##STR5## and its free acid form ##STR6## in which the dotted lines indicated as A and B represent optional double bonds, not more than one of A and B being a double bond, and, where neither A nor B is a double bond, the perhydronaphthyl ring is in the 4aα, 8aβ configuration, together with the pharmaceutically acceptable salts of said free acid and the lower alkyl and substituted lower alkyl esters of said free acid in which said substituent is phenyl, dimethylamino or acetylamino.
Claim 2
Dependent Claim
89 words
A compound of the formula: ##STR5## and its free acid form ##STR6## in which the dotted lines indicated as A and B represent optional double bonds, not more than one of A and B being a double bond, and, where neither A nor B is a double bond, the perhydronaphthyl ring is in the 4aα, 8aβ configuration, together with the pharmaceutically acceptable salts of said free acid and the lower alkyl and substituted lower alkyl esters of said free acid in which said substituent is phenyl, dimethylamino or acetylamino.
Claim 3
Dependent Claim
12 words
The compound of claim 1 which is the lactone of Formula II.
Claim 4
Dependent Claim
14 words
The pharmaceutically acceptable salts of the free acid of Formula III of claim 1.
Claim 5
Dependent Claim
8 words
The esters of Compound III of claim 1.
Claim 6
Dependent Claim
10 words
The free acid form of Compound III of claim 1.
Claim 7
Dependent Claim
12 words
The compounds of claim 2 in which A is a double bond.
Claim 8
Dependent Claim
12 words
The compound of claim 2 in which B is a double bond.
Claim 9
Dependent Claim
21 words
The compounds of claim 2 in which neither A nor B is a double bond and the ring system is transfused.
Claim 10
Dependent Claim
33 words
A method of treating hypercholesterolemia which comprises the administration to a patient in need of such treatment of an effective antihypercholesterolemic amount of a compound of formula II or III of claim 1.
Claim 11
Dependent Claim
24 words
An antihypercholesterolemic pharmaceutical composition comprising a pharmaceutical carrier and an antihypocholesterolemic effective amount of a compound of formula II or III of claim 1.
References Cited (Backward Citations)
US3072709A
Cited
US3344169A
Cited
US4293446A
Cited
US4323648A
Cited
US4231938A
Cited
US4319039A
Cited
US4294846A
Cited
US4282155A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-27 | 1986-03-29 | 1986-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-27 | 1990-03-29 | 1990-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-27 | 1994-03-29 | 1994-09-28 | $7700.00 | Window Closed / Lapsed |