Patent US4339433A successfully refreshed from Google Patents.
US4339433A
Expired / Lapsed
US
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Additives for peritoneal dialysis solutions
Assignee: Baxter International Inc
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Filing: 1981-01-09
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Granted: 1982-07-13
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Expires: 2001-01-09
Abstract
Abstract Various polymers are added to peritoneal dialysis solutions to provide preferred alternatives to dextrose. The added polymers serve as the osmotic agents in the peritoneal dialysis solutions and provide adequate ultrafiltration.
Inventors
- 👤 Nicholas J. Kartinos
- 👤 Terry J. McGary
- 👤 Karl D. Nolph
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:26
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/14; A61M1/28; A61M1/287; A61K; A61K31/00; A61K31/74
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
227 words
In a peritoneal dialysis solution containing ion concentration to permit diffusion across the peritoneum after infusion of the solution into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being selected from the group consisting of the predominantly sodium salts of: (a) ethylene-maleic acid copolymer resins; (b) carboxymethylpolysaccharides; (c) carboxymethylpolyvinyl alcohol; (d) polypeptides and proteins containing at least 10 mole percent of peptide units selected from the group consisting of aspartic acid, glutamic acid, and combinations thereof, having pendant carboxyl groups; (e) esters of polyvinyl alcohol with acids selected from the group consisting of sulfuric acid, phosphoric acid, polycarboxylic acids, and haloalkyl carboxylic acids; having pendant carboxyl groups; (f) the reaction product between (1) polypeptides and proteins having pendant amine groups and (2) acids selected from the group consisting of dicarboxylic acids and anhydrides thereof, haloaliphatic carboxylic acids, and haloalkenic carboxylic acids; (g) polyesters having pendant carboxyl groups, comprising hydroxylpolycarboxylic acids; (h) poly(methylvinyl ether--maleic acid) having pendant carboxyl groups; (i) the reaction product of (1) an amino acid and (2) acid halides of dicarboxylic acids, to yield a polyamide polymer chain having pendant carboxyl groups; and (j) predominantly sodium salts of dextran sulfate having a molecular weight of 2,000 to 120,000.
Claim 2
Dependent Claim
227 words
In a peritoneal dialysis solution containing ion concentration to permit diffusion across the peritoneum after infusion of the solution into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being selected from the group consisting of the predominantly sodium salts of: (a) ethylene-maleic acid copolymer resins; (b) carboxymethylpolysaccharides; (c) carboxymethylpolyvinyl alcohol; (d) polypeptides and proteins containing at least 10 mole percent of peptide units selected from the group consisting of aspartic acid, glutamic acid, and combinations thereof, having pendant carboxyl groups; (e) esters of polyvinyl alcohol with acids selected from the group consisting of sulfuric acid, phosphoric acid, polycarboxylic acids, and haloalkyl carboxylic acids; having pendant carboxyl groups; (f) the reaction product between (1) polypeptides and proteins having pendant amine groups and (2) acids selected from the group consisting of dicarboxylic acids and anhydrides thereof, haloaliphatic carboxylic acids, and haloalkenic carboxylic acids; (g) polyesters having pendant carboxyl groups, comprising hydroxylpolycarboxylic acids; (h) poly(methylvinyl ether--maleic acid) having pendant carboxyl groups; (i) the reaction product of (1) an amino acid and (2) acid halides of dicarboxylic acids, to yield a polyamide polymer chain having pendant carboxyl groups; and (j) predominantly sodium salts of dextran sulfate having a molecular weight of 2,000 to 120,000.
Claim 3
Dependent Claim
23 words
The peritoneal dialysis solution of claim 1 in which said osmolarity-increasing agent is a mixed salt including sodium, potassium, magnesium, and calcium ions.
Claim 4
Dependent Claim
65 words
In a peritoneal dialysis solution containing ion concentration to permit safe diffusion exchange across the peritoneum after diffusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of an ethylene-maleic acid copolymer resin.
Claim 5
Dependent Claim
65 words
In a peritoneal dialysis solution containing ion concentration to permit safe diffusion exchange across the peritoneum after diffusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of an ethylene-maleic acid copolymer resin.
Claim 6
Dependent Claim
63 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of a carboxymethylpolysaccharide.
Claim 7
Dependent Claim
63 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of a carboxymethylpolysaccharide.
Claim 8
Dependent Claim
14 words
The peritoneal dialysis solution of claim 4 in which said polysaccharide is an oligosaccharide.
Claim 9
Dependent Claim
15 words
The peritoneal dialysis solution of claim 4 in which said polysaccharide is a carboxymethyl starch.
Claim 10
Dependent Claim
63 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of carboxymethylpolyvinyl alcohol.
Claim 11
Dependent Claim
63 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of carboxymethylpolyvinyl alcohol.
Claim 12
Dependent Claim
90 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of polypeptides and proteins containing at least ten mole percent of peptide units selected from the group consisting of aspartic acid, glutamic acid, and combinations thereof, having pendant carboxyl groups.
Claim 13
Dependent Claim
90 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of polypeptides and proteins containing at least ten mole percent of peptide units selected from the group consisting of aspartic acid, glutamic acid, and combinations thereof, having pendant carboxyl groups.
Claim 14
Dependent Claim
87 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of esters of polyvinyl alcohol with acids selected from the group consisting of sulfuric acid, phosphoric acid, polycarboxylic acids, and haloalkyl carboxylic acids, having pendant carboxyl groups.
Claim 15
Dependent Claim
87 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of esters of polyvinyl alcohol with acids selected from the group consisting of sulfuric acid, phosphoric acid, polycarboxylic acids, and haloalkyl carboxylic acids, having pendant carboxyl groups.
Claim 16
Dependent Claim
94 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product between (1) polypeptides and proteins having pendant amine groups and (2) acids selected from the group consisting of dicarboxylic acids and anhydrides thereof, haloaliphatic carboxylic acids, and haloalkenic carboxylic acids.
Claim 17
Dependent Claim
94 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product between (1) polypeptides and proteins having pendant amine groups and (2) acids selected from the group consisting of dicarboxylic acids and anhydrides thereof, haloaliphatic carboxylic acids, and haloalkenic carboxylic acids.
Claim 18
Dependent Claim
69 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of polyesters having pendant carboxyl groups, comprising hydroxypolycarboxylic acids.
Claim 19
Dependent Claim
69 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of polyesters having pendant carboxyl groups, comprising hydroxypolycarboxylic acids.
Claim 20
Dependent Claim
69 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of poly (methylvinyl ether-maleic acid) having pendant carboxyl groups.
Claim 21
Dependent Claim
69 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of poly (methylvinyl ether-maleic acid) having pendant carboxyl groups.
Claim 22
Dependent Claim
87 words
In a peritoneal dialysis solution containing a physiological ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product of (1) an amino acid and (2) acid halides of dicarboxylic acids, to yield a polyamide polymer chain having pendant carboxyl groups.
Claim 23
Dependent Claim
87 words
In a peritoneal dialysis solution containing a physiological ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product of (1) an amino acid and (2) acid halides of dicarboxylic acids, to yield a polyamide polymer chain having pendant carboxyl groups.
Claim 24
Dependent Claim
71 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of dextran sulfate having a molecular weight of 2,000 to 120,000.
Claim 25
Dependent Claim
71 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of dextran sulfate having a molecular weight of 2,000 to 120,000.
Claim 26
Dependent Claim
93 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product of a gelatin and a material selected from the group consisting of dicarboxylic acids and anhydrides thereof, said reaction product comprising a polyionic protein material having pendant carboxyl groups.
Claim 27
Dependent Claim
93 words
In a peritoneal dialysis solution containing an ion concentration to permit safe diffusion exchange across the peritoneum after infusion into the peritoneal cavity of a patient, the improvement comprising: said solution containing a polyionic osmolarity-increasing agent which is of a molecular weight sufficient to essentially prevent diffusion of said agent across the peritoneum, said agent being a predominantly sodium salt of the reaction product of a gelatin and a material selected from the group consisting of dicarboxylic acids and anhydrides thereof, said reaction product comprising a polyionic protein material having pendant carboxyl groups.
Claim 28
Dependent Claim
26 words
The peritoneal dialysis solution of claim 15 in which said dicarboxylic acids are selected from the group consisting of succinic acid, maleic acid, and tartaric acid.
Claim 29
Dependent Claim
15 words
The peritoneal dialysis solution of claim 15 in which said dicarboxylic acid is succinic acid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-12 | 1986-01-11 | 1986-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-12 | 1990-01-11 | 1990-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-12 | 1994-01-11 | 1994-07-13 | $7700.00 | Window Closed / Lapsed |