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US4235230A
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Iodine composition and method for prevention and treatment of dialysis induced peritonitis
Assignee: University of Utah Research Foundation Inc
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Filing: 1979-02-12
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Granted: 1980-11-25
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Expires: 1999-02-12
Abstract
Abstract A composition and method for use with peritoneal dialysis patients for preventing or treating dialysis induced peritonitis. The method utilizes a flush solution of normal saline to prepare the peritoneal cavity for infusion of a dilute iodine solution which operates to kill pathogenic organisms contained therein. The dilute iodine solution has a combination I 2 and HIO concentration in the approximate range of 0.1 ppm to 15 ppm and requires residence time of less than five minutes to provide an effective kill. The serial application of flush and dilute iodine solutions may be applied as part of a regular peritoneal dialysis program to prevent peritonitis or may be used with greater frequency as treatment for existing dialysis induced peritonitis.
Inventors
- 👤 Robert L. Stephen
- 👤 Carl Kablitz
- 👤 Dietz van Dura
- 👤 Curtis L. Atkin
- 👤 Stephen C. Jacobsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:10
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/18; A61M; A61M1/00; A61M1/14; A61M1/28; A61M1/287
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
104 words
A method for prevention or treatment of dialysis induced peritonitis comprising the steps of: (a) preparing a first physiological solution which is free of protein material and of reducing substances capable of converting I 2 or HIO to I - ; (b) preparing a second physiological solution having a combined I 2 , HIO concentration in the range of 0.1 to 15 ppm; (c) flushing a patients' peritoneal cavity with said first solution to remove materials comprising said reducing substances and protein material contained within said cavity; and (d) contacting said cavity with said second solution for a period of at least 30 seconds.
Claim 2
Independent Claim
104 words
A method for prevention or treatment of dialysis induced peritonitis comprising the steps of: (a) preparing a first physiological solution which is free of protein material and of reducing substances capable of converting I 2 or HIO to I - ; (b) preparing a second physiological solution having a combined I 2 , HIO concentration in the range of 0.1 to 15 ppm; (c) flushing a patients' peritoneal cavity with said first solution to remove materials comprising said reducing substances and protein material contained within said cavity; and (d) contacting said cavity with said second solution for a period of at least 30 seconds.
Claim 3
Dependent Claim
24 words
A method as defined in claim 1, wherein said first solution is selected from the group consisting of normal saline, lactate, and acetate solutions.
Claim 4
Dependent Claim
22 words
A method as defined in claim 1, wherein said combined I 2 and HIO concentration is in the range of 1-6 ppm.
Claim 5
Dependent Claim
19 words
A method as defined in claim 1, wherein said combined I 2 and HIO concentration is approximately 2 ppm.
Claim 6
Dependent Claim
30 words
A method as defined in claim 1, wherein said flushing step comprises the component steps of infusing the peritoneal cavity with said first solution and immediately draining the solution therefrom.
Claim 7
Dependent Claim
31 words
A method as defined in claim 1, wherein at least 50 ml or one liter of said first solution is flushed through the peritoneal cavity of an infant or adult respectively.
Claim 8
Dependent Claim
36 words
A method as defined in claim 1, wherein said contacting step comprises the component steps of infusing said second solution into said cavity, allowing the solution to dwell for 0.5 minutes and then draining it therefrom.
Claim 9
Dependent Claim
37 words
A method as defined in claim 1, wherein at least 50 ml or one liter of said second solution for an infant or adult respectively is contacted within the peritoneal cavity for a period of 1-5 minutes.
Claim 10
Dependent Claim
21 words
A method as defined in claim 1, further comprising a plurality of flushing steps prior to application of said contacting step.
Claim 11
Dependent Claim
23 words
A method as defined in claim 1, wherein said flushing and contacting steps are applied as a last phase of peritoneal dialysis treatment.
Claim 12
Dependent Claim
32 words
A method as defined in claim 10, wherein said peritoneal dialysis treatment comprises a manual exchange method followed by said flushing and contacting steps as a final step of the dialysis treatment.
Claim 13
Dependent Claim
32 words
A method as defined in claim 10, wherein said peritoneal dialysis treatment comprises a continuous, ambulatory method (CAPD) during which the flushing and contacting steps are accomplished between dialysate drain and refill.
Claim 14
Dependent Claim
21 words
A method as defined in claim 12, wherein said flushing and contacting steps are performed at least once each 24-hour period.
Claim 15
Dependent Claim
25 words
A method as defined in claim 1, wherein said flushing and contacting steps are applied as part of a treatment for existing dialysis induced peritonitis.
Claim 16
Dependent Claim
23 words
A method as defined in claim 14, wherein said flushing and contacting steps are applied with each dialysis treatment utilizing manual exchange methods.
Claim 17
Dependent Claim
32 words
A method as defined in claim 14, wherein said contacting step is repeated one to six times on at least a first application of dilute iodine as part of the peritonitis treatment.
Claim 18
Dependent Claim
22 words
A method as defined in claim 14, wherein the combined concentration of I 2 and HIO is approximately 2 to 6 ppm.
References Cited (Backward Citations)
US3817860A
Cited
US4133891A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |