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US4337270A
Expired / Lapsed
US
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Novel anthranilic acid derivatives
Assignee: Hisamitsu Pharmaceutical Co Inc
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Filing: 1980-05-21
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Granted: 1982-06-29
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Expires: 2000-05-21
Abstract
Abstract Novel anthranilic acid derivatives of the general formula: ##STR1## wherein X is a halogen atom, an alkoxyl group having 1-3 carbon atoms, an alkyl group having 1-3 carbon atoms or a nitro group, n is an integer of 1-2, Y is an alkoxyl group having 1-3 carbon atoms, m is an integer of 2-3, Z is --COCH═CH-- or --CO--, R 1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and pharmaceutically acceptable salts thereof, which derivatives and salts possess a strong antiallergic action and are thus useful as therapeutically active agents for diseases caused by allergies, such as asthma, hay fever, urticaria and atopic dermatitis; an antiallergic composition comprising the same; and a method of alleviating diseases caused by allergies using the same.
Inventors
- 👤 Kanji Noda
- 👤 Akira Nakagawa
- 👤 Toshiharu Motomura
- 👤 Masayoshi Tsuji
- 👤 Hidetoshi Amano
- 👤 Hiroyuki Ide
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:34
CPC Classifications
C; C07; C07C; C07C235/00; C07C235/02; C07C235/32; C07C235/38; C07C235/42; C07C235/44; C07C235/56
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
75 words
A compound of the general formula (I): ##STR10## wherein X is a halogen atom, an alkoxyl group having 1-3 carbon atoms, an alkyl group having 1-3 carbon atoms or a nitro group, n is an integer of 1-2, Y is an alkoxyl group having 1-3 carbon atoms, m is an integer of 2-3, Z is --COCH═CH--, R 1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
75 words
A compound of the general formula (I): ##STR10## wherein X is a halogen atom, an alkoxyl group having 1-3 carbon atoms, an alkyl group having 1-3 carbon atoms or a nitro group, n is an integer of 1-2, Y is an alkoxyl group having 1-3 carbon atoms, m is an integer of 2-3, Z is --COCH═CH--, R 1 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
56 words
A compound of the general formula (I): ##STR11## wherein X is a halogen atom, a methoxy group or a nitro group, n is an integer of 1-2, Y is a methoxy group, m is an integer of 2-3, Z is --COCH═CH--, R 1 is a hydrogen atom or a methyl group, and pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
56 words
A compound of the general formula (I): ##STR11## wherein X is a halogen atom, a methoxy group or a nitro group, n is an integer of 1-2, Y is a methoxy group, m is an integer of 2-3, Z is --COCH═CH--, R 1 is a hydrogen atom or a methyl group, and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
12 words
A compound according to claim 2, wherein X is a halogen atom.
Claim 6
Dependent Claim
10 words
A compound according to claim 3, wherein n is 1.
Claim 7
Dependent Claim
12 words
A compound according to claim 4, wherein Y is a methoxy group.
Claim 8
Dependent Claim
11 words
The compound as claimed in claim 3 of the formula: ##STR12##
Claim 9
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR13##
Claim 10
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR14##
Claim 11
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR15##
Claim 12
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR16##
Claim 13
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR17##
Claim 14
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR18##
Claim 15
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR19##
Claim 16
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR20##
Claim 17
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR21##
Claim 18
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR22##
Claim 19
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR23##
Claim 20
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR24##
Claim 21
Dependent Claim
11 words
The compound as claimed in claim 5 of the formula: ##STR25##
Claim 22
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR26##
Claim 23
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR27##
Claim 24
Dependent Claim
11 words
The compound as claimed in claim 2 of the formula: ##STR28##
Claim 25
Dependent Claim
11 words
The compound as claimed in claim 1 of the formula: ##STR29##
Claim 26
Dependent Claim
31 words
An antiallergic composition comprising a therapeutically effective amount of at least one compound of the general formula (I) according to claim 1 and one or more pharmaceutically acceptable carriers or diluents.
Claim 27
Dependent Claim
44 words
A method of alleviating diseases caused by allergies, such as asthma, hay fever, urticaria and atopic dermatitis, comprising administering a therapeutically effective amount of at least one compound of the general formula (I), according to claim 1 to a subject afflicted with said diseases.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |