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US3940422A Expired / Lapsed US ⏱️ 0.0 years remaining

Aromatic carboxylic amide derivatives

Assignee: Kissei Pharmaceutical Co Ltd
•
Filing: 1974-01-17
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Granted: 1976-02-24
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Expires: 1994-01-17
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Abstract

Abstract Novel aromatic carboxylic amides of the general formula: ##EQU1## wherein each of R 1 and R 2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R 3 and R 4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3, with the proviso that when two Xs are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof. These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, anticaria and atopic dermatitis. The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##EQU2## wherein R 1 , R 2 , R 3 , R 4 , X and n have the same meanings given above, with an aminobenzoic acid of the formula: And, if desired, converting the resulting amide into the corresponding salts.

Inventors

  • 👤 Kozaburo Harita
  • 👤 Yukiyoshi Ajisawa
  • 👤 Kinji Iizuka
  • 👤 Yukihiko Kinoshita
  • 👤 Tetsuhide Kamijo
  • 👤 Michihiro Kobayashi

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 15:48
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61P; A61P37/00; A61P37/08; C; C07; C07C; C07C233/00; C07C233/01; C07C233/12

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 111 words
A compound selected from the group consisting of an aromatic carboxylic amide derivative of the formula: ##EQU8## and therapeutically acceptable salts thereof, in which R 1 and R 2 are each a hydrogennatom or an alkyl group having 1-4 carbon atoms, R 3 and R 4 are each a hydrogen atom or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group having 1-4 carbon atoms, and n is an integer of 1-3, provided that when two X's are said alkyl or alkoxy groups, the alkyl groups thereof may be connected together into an alkylene group.
Claim 2
Dependent Claim 111 words
A compound selected from the group consisting of an aromatic carboxylic amide derivative of the formula: ##EQU8## and therapeutically acceptable salts thereof, in which R 1 and R 2 are each a hydrogennatom or an alkyl group having 1-4 carbon atoms, R 3 and R 4 are each a hydrogen atom or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group having 1-4 carbon atoms, and n is an integer of 1-3, provided that when two X's are said alkyl or alkoxy groups, the alkyl groups thereof may be connected together into an alkylene group.
Claim 3
Dependent Claim 42 words
A compound of claim 1 selected from the group consisting of a nucleus-substituted cinnamic amide of the general formula: ##EQU9## wherein R 1 , R 2 , X and n have the same meanings as given above, and therapeutically acceptable salts thereof.
Claim 4
Dependent Claim 15 words
A compound of claim 2 wherein both R 1 and R 2 are hydrogen atoms.
Claim 5
Dependent Claim 23 words
A compound of claim 2 wherein at least one of R 1 and R 2 is an alkyl group having 1-4 carbon atoms.
Claim 6
Dependent Claim 41 words
A compound of claim 1 selected from the group consisting of a nucleus-substituted phenylpropionamide of the general formula: ##EQU10## wherein R 1 , R 2 , X and n have the same meanings as given above, and therapeutically acceptable salts thereof.
Claim 7
Dependent Claim 15 words
A compound of claim 5 wherein both R 1 and R 2 are hydrogen atoms.
Claim 8
Dependent Claim 23 words
A compound of claim 5 wherein at least one of R 1 and R 2 is an alkyl group having 1-4 carbon atoms.

References Cited (Backward Citations)

US3488737A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-02-23 1979-08-25 1980-02-24 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-02-23 1983-08-25 1984-02-24 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-02-23 1987-08-25 1988-02-24 $7700.00 Window Closed / Lapsed

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