Patent US4335094A successfully refreshed from Google Patents.
US4335094A
Expired / Lapsed
US
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Magnetic polymer particles
Assignee: Individual
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Filing: 1978-06-01
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Granted: 1982-06-15
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Expires: 1998-06-01
Abstract
Abstract This invention relates to magnetic polymer particles as carriers of biologically, preferably pharmaceutically, active substances, the utilization of the magnetic polymer particles, the method of retaining a biologically active substance, preferably a pharmaceutically active substance within a restricted area, and the method of treating diseased tissue with the use of the magnetic polymer particles.
Inventors
- 👤 Klaus H. Mosbach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:13
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/14; A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; C12N11/02; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; G01N33/54326; G01N33/5434; G01N2400/00; G01N2400/10; G01N2400/12; G01N2400/32; G01N2446/00; G01N2446/10
Claims Analysis
Total Claims: 52
Claim 1
Independent Claim
56 words
Magnetic polymer particles as carriers of biologically active substance comprising particles of a polymer having a lattice or pores; a biologically active substance associated with said polymer particles, and magnetic material deposited in said lattice or pores wherein said magnetic material is deposited by contacting the polymer particles with a colloidal solution comprising said magnetic material.
Claim 2
Dependent Claim
56 words
Magnetic polymer particles as carriers of biologically active substance comprising particles of a polymer having a lattice or pores; a biologically active substance associated with said polymer particles, and magnetic material deposited in said lattice or pores wherein said magnetic material is deposited by contacting the polymer particles with a colloidal solution comprising said magnetic material.
Claim 3
Dependent Claim
64 words
Magnetic polymer particles as carriers of biologically active substance, comprising particles of a polymer, which is derived from polymerizable monomers, said particles having a lattice or pores, a biologically active substance associated with said polymer particles, and magnetic material deposited in said lattice or pores, wherein said magnetic material is deposited by contacting the polymerizable monomers with a colloidal solution comprising said magnetic material.
Claim 4
Dependent Claim
64 words
Magnetic polymer particles as carriers of biologically active substance, comprising particles of a polymer, which is derived from polymerizable monomers, said particles having a lattice or pores, a biologically active substance associated with said polymer particles, and magnetic material deposited in said lattice or pores, wherein said magnetic material is deposited by contacting the polymerizable monomers with a colloidal solution comprising said magnetic material.
Claim 5
Dependent Claim
18 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the biologically active substance is pharmaceutically active.
Claim 6
Dependent Claim
39 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the biologically active substance is selected from the group consisting of an enzyme inhibitor, an enzyme, a cytostaticum, a radio nucleotid, insulin, a steroid and a live microbe.
Claim 7
Dependent Claim
19 words
Magnetic polymer particles as claimed in claim 1 or 2 wherein the biologically active substance is a proteolytic enzyme.
Claim 8
Dependent Claim
15 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the polymer is porous.
Claim 9
Dependent Claim
15 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the polymer is biodegradable.
Claim 10
Dependent Claim
26 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the polymer is selected from the group consisting of an acrylic polymer, and a polysaccharide.
Claim 11
Dependent Claim
23 words
Magnetic polymer particles as claimed in claim 1 or 2, wherein the polymer is selected from the group consisting of agarose and starch.
Claim 12
Dependent Claim
18 words
Magnetic polymer particles as claimed in either of claims 1 or 2, wherein the magnetic material is colloidal.
Claim 13
Dependent Claim
15 words
Magnetic polymer particles as claimed in claim 9, wherein the magnetic material is colloidal ferrite.
Claim 14
Dependent Claim
57 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the step of contacting polymer particles having a lattice or pores, which particles carry the biologically active substance, with a colloidal solution of magnetic material, such that the magnetic material is deposited in the pores or lattice of said polymer particles.
Claim 15
Dependent Claim
57 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the step of contacting polymer particles having a lattice or pores, which particles carry the biologically active substance, with a colloidal solution of magnetic material, such that the magnetic material is deposited in the pores or lattice of said polymer particles.
Claim 16
Dependent Claim
60 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the step of contacting polymer particles having a lattice or pores with a colloidal solution of magnetic material and the biologically active substance, such that the magnetic material and the biologically active substance are deposited in the pores or lattice of said polymer particles.
Claim 17
Dependent Claim
60 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the step of contacting polymer particles having a lattice or pores with a colloidal solution of magnetic material and the biologically active substance, such that the magnetic material and the biologically active substance are deposited in the pores or lattice of said polymer particles.
Claim 18
Dependent Claim
61 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymer particles having a lattice or pores with a colloidal solution of magnetic material such that the magnetic material is deposited in the pores or lattice of said polymer particle, and associating the biologically active substance with the magnetic polymer particles.
Claim 19
Dependent Claim
61 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymer particles having a lattice or pores with a colloidal solution of magnetic material such that the magnetic material is deposited in the pores or lattice of said polymer particle, and associating the biologically active substance with the magnetic polymer particles.
Claim 20
Dependent Claim
61 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymerizable monomers in a colloidal solution of magnetic material and polymerizing said monomers, such that said magnetic material is deposited in pores or a lattice of the resulting polymer particles, and associating the biologically active substance with the magnetic polymer particles.
Claim 21
Dependent Claim
61 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymerizable monomers in a colloidal solution of magnetic material and polymerizing said monomers, such that said magnetic material is deposited in pores or a lattice of the resulting polymer particles, and associating the biologically active substance with the magnetic polymer particles.
Claim 22
Dependent Claim
60 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymerizable monomers in a colloidal solution of magnetic material and the biologically active substance and polymerizing said monomers, such that said magnetic material and the biologically active substance are deposited in pores or a lattice of the resulting polymer particles.
Claim 23
Dependent Claim
60 words
A process for the production of magnetic polymer particles as carriers for biologically active substance comprising the steps of contacting polymerizable monomers in a colloidal solution of magnetic material and the biologically active substance and polymerizing said monomers, such that said magnetic material and the biologically active substance are deposited in pores or a lattice of the resulting polymer particles.
Claim 24
Dependent Claim
37 words
The process according to claim 12, 13 or 14 wherein said colloidal solution contains a solvent and said process further comprises the step of removing solvent from said colloidal solution of magnetic material after said contacting step.
Claim 25
Dependent Claim
36 words
The process according to claim 15 or 16 wherein said colloidal solution contains a solvent and said process further comprises the step of removing solvent from said colloidal solution of magnetic material after said polymerization step.
Claim 26
Dependent Claim
29 words
A process as claimed in any one of claims 12 to 16, wherein there is associated with the magnetic polymer particles as biologically active substance a pharmaceutically active substance.
Claim 27
Dependent Claim
50 words
A process as claimed in any one of claims 12 to 16, wherein there is associated with the magnetic polymer particles as biologically active substance a substance selected from the group consisting of an enzyme inhibitor, an enzyme, a cytostaticum, a radio nucleotid, insulin, a steroid and a live microbe.
Claim 28
Dependent Claim
28 words
A process as claimed in any one of claims 12 to 16, wherein there is associated with the magnetic polymer particles as biologically active substance a proteolytic enzyme.
Claim 29
Dependent Claim
23 words
A process as claimed in any one of claims 12 to 16, wherein as polymer particles use is made of porous polymer particles.
Claim 30
Dependent Claim
20 words
A process as claimed in any one of claims 12 to 16, wherein use is made of a biodegradable polymer.
Claim 31
Dependent Claim
33 words
A process as claimed in any one of claims 12 to 16, wherein as polymer particles use is made of particles selected from the group consisting of an acrylic polymer and a polysaccharide.
Claim 32
Dependent Claim
30 words
A process as claimed in any one of claims 12 to 16, wherein as polymer particles use is made of particles selected from the group consisting of agarose and starch.
Claim 33
Dependent Claim
18 words
A process as claimed in claim 15 or 16, wherein an acrylic monomer is inserted as polymerizable monomer.
Claim 34
Dependent Claim
20 words
A process as claimed in any one of claims 12 to 16, wherein colloidal ferrite is used as magnetic material.
Claim 35
Independent Claim
66 words
A method of retaining a biologically active substance within a restricted area, characterized in that the biologically active substance is associated with particles of a polymer, which particles are given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, whereupon a magnetic field is applied to the restricted area for retaining the magnetic polymer particles with the substance associated therewith.
Claim 36
Independent Claim
66 words
A method of retaining a biologically active substance within a restricted area, characterized in that the biologically active substance is associated with particles of a polymer, which particles are given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, whereupon a magnetic field is applied to the restricted area for retaining the magnetic polymer particles with the substance associated therewith.
Claim 37
Dependent Claim
19 words
A method of retaining a biologically active substance as described in claim 28, wherein the substance is pharmaceutically active.
Claim 38
Dependent Claim
18 words
A method of retaining a biologically active substance as described in claim 28, wherein the polymer is porous.
Claim 39
Dependent Claim
18 words
A method of retaining a biologically active substance as described in claim 28, wherein the polymer is biodegradable.
Claim 40
Dependent Claim
35 words
A method of retaining a biologically active substance as described in claim 28, wherein the polymer is selected from the group consisting of red corpuscles, particles of a liposome, an acrylic polymer and a polysaccharide.
Claim 41
Dependent Claim
20 words
A method of retaining a biologically active substance as described in claim 32, wherein said polymer is agarose or starch.
Claim 42
Independent Claim
83 words
A method of treating a diseased tissue, characterized in that an effective amount of a pharmaceutically active substance is concentrated in the tissue by supply of the substance to the tissue associated with a carrier in the form of polymer particles, which have been given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, and that the magnetic carrier with the associated pharmaceutical substance is concentrated to the diseased tissue by the application of a magnetic field.
Claim 43
Independent Claim
83 words
A method of treating a diseased tissue, characterized in that an effective amount of a pharmaceutically active substance is concentrated in the tissue by supply of the substance to the tissue associated with a carrier in the form of polymer particles, which have been given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, and that the magnetic carrier with the associated pharmaceutical substance is concentrated to the diseased tissue by the application of a magnetic field.
Claim 44
Dependent Claim
19 words
A method of treating a diseased tissue as described in claim 34, wherein the polymer is porous and/or biodegradable.
Claim 45
Dependent Claim
54 words
Magnetic starch particles as carriers of biologically active substance comprising particles of starch having a lattice or pores; a biologically active substance associated with said starch particles, and magnetic material deposited in said lattice or pores wherein said magnetic material is deposited by contacting starch particles with a colloidal solution comprising saig magnetic material.
Claim 46
Dependent Claim
54 words
Magnetic starch particles as carriers of biologically active substance comprising particles of starch having a lattice or pores; a biologically active substance associated with said starch particles, and magnetic material deposited in said lattice or pores wherein said magnetic material is deposited by contacting starch particles with a colloidal solution comprising saig magnetic material.
Claim 47
Independent Claim
65 words
A method of retaining a biologically active substance within a restricted area, characterized in that the biologically active substance is associated with particles of starch, which particles are given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, whereupon a magnetic field is applied to the restricted area for retaining the magnetic starch particles with the substance associated therewith.
Claim 48
Independent Claim
65 words
A method of retaining a biologically active substance within a restricted area, characterized in that the biologically active substance is associated with particles of starch, which particles are given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, whereupon a magnetic field is applied to the restricted area for retaining the magnetic starch particles with the substance associated therewith.
Claim 49
Independent Claim
83 words
A method of treating a diseased tissue, characterized in that an effective amount of a pharmaceutically active substance is concentrated in the tissue by supply of the substance to the tissue associated with a carrier in the form of starch particles, which have been given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, and that the magnetic carrier with the associated pharmaceutical substance is concentrated to the diseased tissue by the application of a magnetic field.
Claim 50
Independent Claim
83 words
A method of treating a diseased tissue, characterized in that an effective amount of a pharmaceutically active substance is concentrated in the tissue by supply of the substance to the tissue associated with a carrier in the form of starch particles, which have been given magnetic properties by incorporation of a magnetic material in the form of a colloidal solution, and that the magnetic carrier with the associated pharmaceutical substance is concentrated to the diseased tissue by the application of a magnetic field.
Claim 51
Dependent Claim
57 words
A process for the production of magnetic starch particles as carriers for biologically active substance comprising the step of contacting starch particles having a lattice or pores, which particles carry the biologically active substance, with a colloidal solution of magnetic material, such that the magnetic material is deposited in the pores or lattice of said starch particles.
Claim 52
Dependent Claim
57 words
A process for the production of magnetic starch particles as carriers for biologically active substance comprising the step of contacting starch particles having a lattice or pores, which particles carry the biologically active substance, with a colloidal solution of magnetic material, such that the magnetic material is deposited in the pores or lattice of said starch particles.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |