Patent US4320758A successfully refreshed from Google Patents.
US4320758A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Osmotically driven fluid dispenser
Assignee: Alza Corp
•
Filing: 1980-12-08
•
Granted: 1982-03-23
•
Expires: 2000-12-08
Abstract
Abstract An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the bag opening; a solution filling/discharge port through the plug; a cup-shaped, thermo-formed sleeve that fits partly about the bag and is made from a dispersion of an osmotically effective solute in a water soluble, theroplastic polymer vehicle; a shape-retaining, semipermeable membrane that encapulates the bag-sleeve subassembly; and a flow moderator that is received through the filling/discharge port in the plug.
Inventors
- 👤 James B. Eckenhoff
- 👤 Johan H. Geerke
- 👤 Felix A. Landrau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:20
CPC Classifications
B; B01; B01D; B01D71/00; B01D71/06; B01D71/26; B01D71/261; A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M; A61M31/00; A61M31/002; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M5/1452; A61M5/14526; A61M5/14586; A61M5/14593; A61M5/148; B01D63/00; A61M2005/14513
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
133 words
In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting essentially of a dispersion of about 50% to about 90% by weight osmotically effective solute, in about 10% to about 50% by weight water soluble thermoplastic polymer vehicle.
Claim 2
Dependent Claim
133 words
In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmotically effective solute composition, said membrane being at least in part permeable to water, and a port that extends from the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting essentially of a dispersion of about 50% to about 90% by weight osmotically effective solute, in about 10% to about 50% by weight water soluble thermoplastic polymer vehicle.
Claim 3
Dependent Claim
36 words
The improvement of claim 1 wherein the osmotically effective solute constitutes about 60% to about 70% by weight of the dispersion and the polymer vehicle constitutes about 30% to about 40% by weight of the dispersion.
Claim 4
Dependent Claim
57 words
The improvement of claim 1 wherein the polymer vehicle consists essentially of about 40% to about 70% by weight poly(ethylene oxide) having a molecular weight in the range of about 100,000 to about 4,000,000 and about 30% to about 60% by weight poly(ethylene glycol) having a molecular weight in the range of about 1,000 to about 30,000.
Claim 5
Dependent Claim
39 words
The improvement of claim 1 wherein the osmotically effective solute is sodium chloride and the vehicle consists of a mixture of poly(etyhlene oxide) of about 600,000 molecular weight, poly(ethylene glycol) of about 20,000 molecular weight, and colloidal silicon dioxide.
Claim 6
Dependent Claim
145 words
In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmostically effective solute composition, said membrane being at least in part permeable to water, and a port that extends form the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting of a mixture of 64.5% by weight sodium chloride, 20% by weight poly(ethylene oxide) having a molecular weight of about 600,000, 15% by weight poly(ethylene glycol) having a molecular weight of about 20,000 and 0.5% by weight colloidal silicon dioxide.
Claim 7
Dependent Claim
145 words
In an osmotically driven fluid dispenser comprising an inner flexible bag adapted to contain the fluid, an intermediate layer of an osmotically effective solute composition at least partly encapsulating the bag, an outer, shape-retaining membrane encapsulating the layer of osmostically effective solute composition, said membrane being at least in part permeable to water, and a port that extends form the interior of the bag to the exterior of the dispenser through which the fluid may be charged into the bag and dispensed from the bag, the improvement wherein the layer of the osmotically effective solute composition is in the form of a thermoformed sleeve consisting of a mixture of 64.5% by weight sodium chloride, 20% by weight poly(ethylene oxide) having a molecular weight of about 600,000, 15% by weight poly(ethylene glycol) having a molecular weight of about 20,000 and 0.5% by weight colloidal silicon dioxide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-22 | 1985-09-21 | 1986-03-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-22 | 1989-09-21 | 1990-03-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-22 | 1993-09-21 | 1994-03-23 | $7700.00 | Window Closed / Lapsed |