US4165370A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Injectable gamma globulin
Assignee: Individual
•
Filing: 1978-04-27
•
Granted: 1979-08-21
•
Expires: 1998-04-27
Abstract
Abstract A process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste. The Fraction II or II + III paste is extracted with water at a pH of 4.8-6.5 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt./vol. and then 5% wt./vol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt./vol.
Inventors
- 👤 Myer Louis Coval
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:05
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
132 words
A gamma globulin suitable for intravenous administration prepared according to the following process: a process for preparing a gamma globulin substantially devoid of anticomplementary activity and suitable for intravenous administration, from a material selected from the Fraction II+III plasma protein paste having a protein content of about 25--30% and Fraction II paste which comprises the steps: a. suspending said paste in water to form a solution of low ionic strength having a conductance of about 300-10 -6 cm -1 ohm -1 at a pH of about 4.8 to 6.5 to produce a precipitate and a filtrate, b. fractionally precipitating impurities from said filtrate by adding polyethylene glycol to 4% weight/volume and then 5% weight/volume, c. precipitating the gamma globulin by adding polyethylene glycol to 12% weight/volume at a pH of about 8.0.
Claim 2
Dependent Claim
132 words
A gamma globulin suitable for intravenous administration prepared according to the following process: a process for preparing a gamma globulin substantially devoid of anticomplementary activity and suitable for intravenous administration, from a material selected from the Fraction II+III plasma protein paste having a protein content of about 25--30% and Fraction II paste which comprises the steps: a. suspending said paste in water to form a solution of low ionic strength having a conductance of about 300-10 -6 cm -1 ohm -1 at a pH of about 4.8 to 6.5 to produce a precipitate and a filtrate, b. fractionally precipitating impurities from said filtrate by adding polyethylene glycol to 4% weight/volume and then 5% weight/volume, c. precipitating the gamma globulin by adding polyethylene glycol to 12% weight/volume at a pH of about 8.0.
Claim 3
Dependent Claim
34 words
A solution of the gamma globulin according to claim 1 for intravenous administration comprising the gamma globulin in a aqueous solution containing albumin, a non-ionic surfactant, glycine and acetic acid-acetate buffer at pH 5.4-6.7.
Claim 4
Dependent Claim
19 words
A solution of gamma globulin according to claim 2 wherein the non-ionic surfactant is Tween 80 or Pluronic 68.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-20 | 1983-02-19 | 1983-08-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-20 | 1987-02-19 | 1987-08-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-20 | 1991-02-19 | 1991-08-21 | $7700.00 | Window Closed / Lapsed |