US4021540A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Preparation of a hepatitis B immune globulin and use thereof as a prophylactic material
Assignee: Ortho Clinical Diagnostics Inc
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Filing: 1975-07-28
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Granted: 1977-05-03
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Expires: 1995-07-28
Abstract
Abstract A method for producing a novel immunizing agent is described. The immunizing agent is anti-HB s gamma globulin essentially free of fibrinogen, plasminogen, 19 S globulin and lipids found to be effective in immunizing against hepatitis B virus disease. The method of producing this material involves fractionation of human plasma utilizing selective solvent and control of pH, temperature and ionic strength.
Inventors
- 👤 William Pollack
- 👤 Albert McKee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:12
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/08; C07K16/081; C07K16/082; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/82; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
18 words
An essentially pure anti-HB s gamma globulin being essentially free of plasminogen, fibrinogen, lipids and 19 S globulins.
Claim 2
Dependent Claim
18 words
An essentially pure anti-HB s gamma globulin being essentially free of plasminogen, fibrinogen, lipids and 19 S globulins.
Claim 3
Independent Claim
41 words
The method of immunizing against the incidence of hepatitis B viral disease which comprises parenterally administering to a susceptible host an effective amount of an essentially pure anti-HB s gamma globulin essentially free of plasminogen, fibrinogen, lipids and 19 S globulins.
Claim 4
Independent Claim
41 words
The method of immunizing against the incidence of hepatitis B viral disease which comprises parenterally administering to a susceptible host an effective amount of an essentially pure anti-HB s gamma globulin essentially free of plasminogen, fibrinogen, lipids and 19 S globulins.
Claim 5
Dependent Claim
15 words
The method according to claim 2, wherein the anti-HB s gamma globulin is administered intra-muscularly.
Claim 6
Dependent Claim
31 words
The method according to claim 3 wherein the amount of anti-HB s gamma globulin administered corresponds to 25 to 50 micrograms of specific anti-HB s per kilogram of host body weight.
Claim 7
Dependent Claim
29 words
The method according to claim 4 wherein the anti-HB s gamma globulin administered contains approximately 442 micrograms of specific anti-HB s per ml. measured by quantitative solid phase radioimmunoassay.
Claim 8
Dependent Claim
21 words
The gamma globulin of claim 1 wherein the gamma globulin is derived from a high titre anti-HB s human source plasma.
Claim 9
Dependent Claim
25 words
The anti-HB s gamma globulin of claim 6 having a specific HB s antibody titre of at least 442 micrograms per ml. by quantitative radioimmunoassay.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-02 | 1980-11-01 | 1981-05-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-02 | 1984-11-01 | 1985-05-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-02 | 1988-11-01 | 1989-05-03 | $7700.00 | Window Closed / Lapsed |