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US4127647A
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Process for preparation of stable amorphous macrolide antibiotic solids
Assignee: Meiji Seika Kaisha Ltd
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Filing: 1977-10-14
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Granted: 1978-11-28
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Expires: 1997-10-14
Abstract
Abstract Amorphous solids of macrolide antibiotics which are stable with the passage of time are prepared by dissolving a macrolide antibiotic and a cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose as a stabilizing substance in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform and spray drying the resulting solution.
Inventors
- 👤 Toyomi Sato
- 👤 Toshiyuki Kobayashi
- 👤 Takeshi Mayama
- 👤 Akira Okada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K47/00; A61K47/30; A61K47/36; A61K47/38
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
63 words
A process for preparing amorphous solids of macrolide antibiotics which are stable with the passage of time, said process consisting of spray drying a solution in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform of a macrolide antibiotic and at least one cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose.
Claim 2
Dependent Claim
63 words
A process for preparing amorphous solids of macrolide antibiotics which are stable with the passage of time, said process consisting of spray drying a solution in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform of a macrolide antibiotic and at least one cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose.
Claim 3
Dependent Claim
12 words
The process of claim 1, wherein said solvent is dichloromethane or 1,1,1-trichloroethane.
Claim 4
Dependent Claim
28 words
The process of claim 1, wherein the amount of said cellulose polymer is about 5 to about 40% by weight based on the weight of the macrolide antibiotic.
Claim 5
Dependent Claim
28 words
The process of claim 3, wherein the amount of said cellulose polymer is about 10% to about 30% by weight based on the weight of the macrolide antibiotic.
Claim 6
Dependent Claim
25 words
The process of claim 1, wherein the concentration of the macrolide antibiotic in the volatile organic solvent is about 5 to about 50% by weight.
Claim 7
Dependent Claim
24 words
The process of claim 5, wherein the concentration of macrolide antibiotic in the volatile organic solvent is about 10 to about 30% by weight.
Claim 8
Dependent Claim
17 words
The process of claim 1, wherein said cellulose polymer has a molecular weight of above about 1,000.
Claim 9
Dependent Claim
19 words
The process of claim 1, wherein said spray drying is conducted at a temperature of above about 60° C.
Claim 10
Dependent Claim
21 words
A composition comprising at least one amorphous solid macrolide antibiotic and a cellulose polymer prepared by the process of claim 1.
References Cited (Backward Citations)
US3962419A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-27 | 1982-05-29 | 1982-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-27 | 1986-05-29 | 1986-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-27 | 1990-05-29 | 1990-11-28 | $7700.00 | Window Closed / Lapsed |