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US4120949A
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Ophthalmic solution
Assignee: Iolab Corp
•
Filing: 1977-10-05
•
Granted: 1978-10-17
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Expires: 1997-10-05
Abstract
Abstract An ophthalmic solution is disclosed comprising an aqueous solution of polyvinyl alcohol, hydroxyethyl cellulose, polyvinylpyrrolidone, and, optionally, hydroxypropyl methylcellulose. The ophthalmic solution is used in treating dry eye syndrome due to insufficient tear production in humans and mammals, and as an ocular lubricant for inflamed eyes.
Inventors
- 👤 Krishna M. Bapatla
- 👤 Katharyn M. Brychta
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:52
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K31/787; A61K31/79
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
40 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 0.8%
Polyvinylpyrrolidone 1.5%
Polyvinyl alcohol 0.5%
Hydroxypropyl methylcellulose
0.4%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 2
Dependent Claim
40 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 0.8%
Polyvinylpyrrolidone 1.5%
Polyvinyl alcohol 0.5%
Hydroxypropyl methylcellulose
0.4%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 3
Dependent Claim
14 words
An ophthalmic solution according to claim 1 having a pH of 7.6 ± 0.2.
Claim 4
Dependent Claim
37 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 0.8%
Polyvinylpyrrolidone 1.5%
Polyvinyl alcohol 0.5%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 5
Dependent Claim
37 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 0.8%
Polyvinylpyrrolidone 1.5%
Polyvinyl alcohol 0.5%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 6
Dependent Claim
14 words
An ophthalmic solution according to claim 3 having a pH of 7.6 ± 0.2.
Claim 7
Dependent Claim
36 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 1.2%
Polyvinylpyrrolidone 2.0%
Polyvinyl alcohol 2.0%
Thimerosal 0.001%
Disodium edetate 0.1%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 8
Dependent Claim
36 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 1.2%
Polyvinylpyrrolidone 2.0%
Polyvinyl alcohol 2.0%
Thimerosal 0.001%
Disodium edetate 0.1%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 9
Dependent Claim
14 words
An ophthalmic solution according to claim 5 having a pH of 7.6 ± 0.2.
Claim 10
Dependent Claim
37 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 1.2%
Polyvinylpyrrolidone 2.0%
Polyvinyl alcohol 0.5%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 11
Dependent Claim
37 words
An ophthalmic solution having the following composition: ______________________________________
Hydroxyethyl cellulose 1.2%
Polyvinylpyrrolidone 2.0%
Polyvinyl alcohol 0.5%
Benzalkonium chloride 0.01%
Disodium edetate 0.01%
______________________________________ in a physiologically acceptable aqueous phosphate buffer, having a pH of 6.0 to 8.0.
Claim 12
Dependent Claim
14 words
An ophthalmic solution according to claim 7 having a pH of 7.6 ± 0.2.
References Cited (Backward Citations)
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Cited
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US3856919A
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US3843782A
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US3868445A
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US3927205A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-16 | 1982-04-17 | 1982-10-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-16 | 1986-04-17 | 1986-10-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-16 | 1990-04-17 | 1990-10-17 | $7700.00 | Window Closed / Lapsed |