US3927205A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aqueous suspension of pharmaceuticals
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1974-04-09
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Granted: 1975-12-16
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Expires: 1994-04-09
Abstract
Abstract An aqueous suspension consisting basically of pharmaceutically active ingredient(s) which is insoluble or sparingly soluble in water and a suspending agent consisting of (1) crystalline cellulose, (2) at least one component selected from the group consisting of cellulose ether, polyvinyl alcohol and copolymer of polyvinyl alcohol with polyvinyl pyrrolidone, and (3) at least one component selected from the group consisting of polyvinyl pyrrolidone, vegetable mucilage and derived protein, in which said active ingredient(s) can satisfactorily be suspended for administration.
Inventors
- 👤 Yoshitomo Ohno
- 👤 Yasuko Takigawa
- 👤 Katsuo Aoki
- 👤 Takatsuka Yashiki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:53
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K47/32
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
50 words
IN AN AQUEOUS SUSPENSION CONTAINING UP TO 8 PERCENT BY WEIGHT PER VOLUME OF A PHARMACEUTICALLY ACTIVE INGREDIENT(S) WHICH IS INSOLUBLE OR SPARINGLY SOLUBLE IN WATER HAVING AN AVERAGE SIZE PARTICLE SIZE SMALLER THAN ABOUT 100 U AND A SUSPENDING AGENT, THE IMPROVEMENT, WHEREIN THE SUSPENDING AGENT CONSISTS ESSENTIALLY OF
Claim 2
Dependent Claim
50 words
IN AN AQUEOUS SUSPENSION CONTAINING UP TO 8 PERCENT BY WEIGHT PER VOLUME OF A PHARMACEUTICALLY ACTIVE INGREDIENT(S) WHICH IS INSOLUBLE OR SPARINGLY SOLUBLE IN WATER HAVING AN AVERAGE SIZE PARTICLE SIZE SMALLER THAN ABOUT 100 U AND A SUSPENDING AGENT, THE IMPROVEMENT, WHEREIN THE SUSPENDING AGENT CONSISTS ESSENTIALLY OF
Claim 3
Dependent Claim
2 words
CRYSTALLINE CELLULOSE
Claim 4
Dependent Claim
2 words
CRYSTALLINE CELLULOSE
Claim 5
Dependent Claim
27 words
AT LEAST ONE COMPONENT SELECTED FROM THE GROUP CONSITING OF METHYL CELLULOSE, SODIUM CARBOXYMETHYL CELLULOSE AND POLYVINYL ALCOHOL HAVING A MOLECULAR WEIGHT OF 8,000 TO 180,000; AND
Claim 6
Dependent Claim
27 words
AT LEAST ONE COMPONENT SELECTED FROM THE GROUP CONSITING OF METHYL CELLULOSE, SODIUM CARBOXYMETHYL CELLULOSE AND POLYVINYL ALCOHOL HAVING A MOLECULAR WEIGHT OF 8,000 TO 180,000; AND
Claim 7
Dependent Claim
27 words
at least one component selected from the group consisting of methyl cellulose, sodium carboxymethyl cellulose and polyvinyl alcohol having a molecular weight of 8,000 to 180,000; and
Claim 8
Dependent Claim
27 words
at least one component selected from the group consisting of methyl cellulose, sodium carboxymethyl cellulose and polyvinyl alcohol having a molecular weight of 8,000 to 180,000; and
Claim 9
Dependent Claim
16 words
The aqueous suspension as claimed in claim 1, wherein methyl cellulose is employed as component (2).
Claim 10
Dependent Claim
16 words
The aqueous suspension as claimed in claim 1, wherein polyvinyl alcohol is employed as component (2).
Claim 11
Dependent Claim
84 words
at least one component selected from the group consisting of polyvinyl pyrrolidone having a molecular weight of 10,000 to 3000,000, propylene glycol alginate, sodium pectinate, tragacanth gum and gelatin, the amount of component (1) being 0.3 to 5 weight/volume percent of the aqueous suspension, the amount of component (2) plus the component (3) being 0.1 to 4 weight/volume percent of the aqueous suspension and wherein the weight ratio of component (2) relative to component (3) being in the range of from 15/85 to 80/20.
Claim 12
Dependent Claim
84 words
at least one component selected from the group consisting of polyvinyl pyrrolidone having a molecular weight of 10,000 to 3000,000, propylene glycol alginate, sodium pectinate, tragacanth gum and gelatin, the amount of component (1) being 0.3 to 5 weight/volume percent of the aqueous suspension, the amount of component (2) plus the component (3) being 0.1 to 4 weight/volume percent of the aqueous suspension and wherein the weight ratio of component (2) relative to component (3) being in the range of from 15/85 to 80/20.
Claim 13
Dependent Claim
84 words
AT LEAST ONE COMPONENT SELECTED FROM THE GROUP CONSISTING OF POLYVINYL PYRROLIDONE HAVING A MOLECULAR WEIGHT OF 10,000 TO 3000,000, PROPYLENE GLYCOL ALIGNATE, SODIUM PECTINATE, TRAGACANTH GUM AND GELATIN, THE AMOUNT OF COMPONENT (1) BEING 0.3 TO 5 WEIGHT/VOLUME PERCENT OF THE AQUEOUS SUSPENSION, THE AMOUNT OF COMPONENT (2) PLUS THE COMPONENT (3) BEING 0.1 TO 4 WEIGHT/VOLUME PERCENT OF THE AQUEOUS SUSPENSION AND WHEREIN THE WEIGHT RATIO OF COMPONENT (2) RELATIVE TO COMPONENT (3) BEING IN THE RANGE OF FROM 15/85 TO 80/20.
Claim 14
Dependent Claim
84 words
AT LEAST ONE COMPONENT SELECTED FROM THE GROUP CONSISTING OF POLYVINYL PYRROLIDONE HAVING A MOLECULAR WEIGHT OF 10,000 TO 3000,000, PROPYLENE GLYCOL ALIGNATE, SODIUM PECTINATE, TRAGACANTH GUM AND GELATIN, THE AMOUNT OF COMPONENT (1) BEING 0.3 TO 5 WEIGHT/VOLUME PERCENT OF THE AQUEOUS SUSPENSION, THE AMOUNT OF COMPONENT (2) PLUS THE COMPONENT (3) BEING 0.1 TO 4 WEIGHT/VOLUME PERCENT OF THE AQUEOUS SUSPENSION AND WHEREIN THE WEIGHT RATIO OF COMPONENT (2) RELATIVE TO COMPONENT (3) BEING IN THE RANGE OF FROM 15/85 TO 80/20.
Claim 15
Dependent Claim
17 words
The aqueous suspension as claimed in claim 1, wherein sodium carboxymethyl cellulose is employed as component (2).
Claim 16
Dependent Claim
17 words
The aqueous suspension as claimed in claim 1, wherein propylene glycol alginate is employed as component (3).
Claim 17
Dependent Claim
16 words
The aqueous suspension as claimed in claim 1, wherein polyvinyl pyrrolidone is employed as component (3).
Claim 18
Dependent Claim
15 words
The aqueous suspension as claimed in claim 1, wherein gelatin is employed as component (3).
Claim 19
Dependent Claim
16 words
The aqueous suspension as claimed in claim 1, wherein sodium pectinate is employed as component (3).
Claim 20
Dependent Claim
16 words
The aqueous suspension as claimed in claim 1, wherein tragacanth gum is employed as component (3).
Claim 21
Dependent Claim
45 words
The aqueous suspension as claimed in claim 1, wherein the amount of component (1) is 0.5 to 2.5 weight/volume percent of the aqueous suspension and the amount of the component (2) plus the component (3) is 0.2 to 2.5 weight/volume percent of the aqueous suspension.
Claim 22
Dependent Claim
25 words
The aqueous suspension as claimed in claim 1, wherein methyl cellulose is employed as component (2) and propylene glycol alginate is employed as component (3).
Claim 23
Dependent Claim
24 words
The aqueous suspension as claimed in claim 1, wherein polyvinyl alcohol is employed as component (2) and polyvinyl pyrrolidone is employed as component (3).
Claim 24
Dependent Claim
24 words
The aqueous suspension as claimed in claim 1, wherein carboxymethyl cellulose is employed as component (2) and gelatin is employed as the component (3).
Claim 25
Dependent Claim
25 words
The aqueous suspension as claimed in claim 1, wherein sodium carboxymethyl cellulose is employed as component (2) and sodium pectinate is employed as component (3).
Claim 26
Dependent Claim
25 words
The aqueous suspension as claimed in claim 1, wherein sodium carboxymethyl cellulose is employed as component (2) and tragacanth gum is employed as component (3).
References Cited (Backward Citations)
US2725336A
Cited
US2701782A
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US3312594A
Cited
US3351527A
Cited
US3639637A
Cited
US3636200A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-15 | 1979-06-16 | 1979-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-15 | 1983-06-16 | 1983-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-15 | 1987-06-16 | 1987-12-16 | $7700.00 | Window Closed / Lapsed |