Patent US1039093A successfully refreshed from Google Patents.
US4101651A
Expired / Lapsed
US
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Process for preparing preparations for oral administration
Assignee: Meiji Seika Kaisha Ltd
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Filing: 1976-02-03
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Granted: 1978-07-18
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Expires: 1996-02-03
Abstract
Abstract A process for preparing preparations for oral administration which do not have a bitter taste which comprises either dissolving a bitter taste-masking substance at a high concentration in a solvent to be used for dissolving or suspending a bitter active ingredient and adding the active ingredient to the resulting solution followed by kneading, or kneading a solution or suspension in which a bitter active ingredient has been dissolved or suspended with the bitter taste-masking substance, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating the powder using a solution of the bitter taste-masking substance in a fluidized bed granulator.
Inventors
- 👤 Toshiyuki Kobayashi
- 👤 Akio Okada
- 👤 Takeshi Mayama
- 👤 Akira Okada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/1611; A61K9/1635; A61P; A61P31/00; A61P31/04
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
159 words
A process for preparing granular preparations for oral administration having no bitter taste which comprises dissolving a pharmaceutically acceptable water insoluble ethyl cellulose as a bitter taste-masking substance having a molecular weight higher than about 2,000 in high concentration in a volatile solvent to be used for dissolving or suspending midecamycin as a bitter pharmaceutical ingredient, adding the midecamycin to the resulting solution followed by kneading, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating said powder using a solution of the ethyl cellulose in a fluidized bed granulator, said volatile solvent not exerting a degrading effect upon said ethyl cellulose or upon said midecamycin, the amount of said ethyl cellulose to be dissolved in said solvent being about 0.5 to about three times the amount of said midecamycin and the amount of said ethyl cellulose used for said granulation being about 1/10 to about 1/5 the amount thereof used for said dissolving.
Claim 2
Dependent Claim
159 words
A process for preparing granular preparations for oral administration having no bitter taste which comprises dissolving a pharmaceutically acceptable water insoluble ethyl cellulose as a bitter taste-masking substance having a molecular weight higher than about 2,000 in high concentration in a volatile solvent to be used for dissolving or suspending midecamycin as a bitter pharmaceutical ingredient, adding the midecamycin to the resulting solution followed by kneading, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating said powder using a solution of the ethyl cellulose in a fluidized bed granulator, said volatile solvent not exerting a degrading effect upon said ethyl cellulose or upon said midecamycin, the amount of said ethyl cellulose to be dissolved in said solvent being about 0.5 to about three times the amount of said midecamycin and the amount of said ethyl cellulose used for said granulation being about 1/10 to about 1/5 the amount thereof used for said dissolving.
Claim 3
Dependent Claim
158 words
A process for preparing granular preparations for oral administration having no bitter taste which comprises dissolving or suspending midecamycin as a bitter pharmaceutical ingredient in high concentration in a volatile solvent for dissolving a pharmaceutically acceptable, water insoluble ethyl cellulose as a bitter taste-masking substance having a molecular weight higher than about 2,000, adding the ethyl cellulose to the resulting solution or suspension followed by kneading, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating said powder using a solution of said ethyl cellulose in a fluidized bed granulator, said volatile solvent not exerting a degrading effect upon said ethyl cellulose or upon said midecamycin, the amount of said ethyl cellulose added to said solution or said suspension being about 0.5 to about three times the amount of said midecamycin and the amount of said ethyl cellulose used for said granulation being about 1/10 to 1/5 the amount used for said addition.
Claim 4
Dependent Claim
158 words
A process for preparing granular preparations for oral administration having no bitter taste which comprises dissolving or suspending midecamycin as a bitter pharmaceutical ingredient in high concentration in a volatile solvent for dissolving a pharmaceutically acceptable, water insoluble ethyl cellulose as a bitter taste-masking substance having a molecular weight higher than about 2,000, adding the ethyl cellulose to the resulting solution or suspension followed by kneading, adding silicic acid anhydride to the resulting kneaded substance to form a powder and granulating said powder using a solution of said ethyl cellulose in a fluidized bed granulator, said volatile solvent not exerting a degrading effect upon said ethyl cellulose or upon said midecamycin, the amount of said ethyl cellulose added to said solution or said suspension being about 0.5 to about three times the amount of said midecamycin and the amount of said ethyl cellulose used for said granulation being about 1/10 to 1/5 the amount used for said addition.
Claim 5
Dependent Claim
28 words
The process according to claim 1, wherein the amount of said ethyl cellulose is dissolved in an amount of 0.5 to 2 times the amount of the midecamycin.
Claim 6
Dependent Claim
30 words
The process according to claim 2, wherein said ethyl cellulose is added to said solution or suspension in an amount of 0.5 to 2.0 times the amount of said midecamycin.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |