US3859228A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of microcapsule preparation
Assignee: Toyo Jozo KK
•
Filing: 1972-07-31
•
Granted: 1975-01-07
•
Expires: 1992-07-31
Abstract
Abstract A novel method of microcapsule preparation is presented. A polymer for wall film is dissolved in a solvent, having a dielectric constant in the vicinity from 10 to 40 and poorly miscible with a vehicle, i.e, a liquid paraffin or a silicone oil. The solution is emulsified in said vehicle. A core substance which is soluble in the solvent and has a particle size of 100 to 1500 Mu , is dispersed into this emulsion. The emulsion drops of the polymer solution cohere around the cores and envelop them. Finally, the solvent is removed through evaporation under stirring to obtain concentric spherical microcapsules. This method is suitable for the preparation of microcapsules of various substances, especially those unstable to heat, pH, etc., such as medicaments.
Inventors
- 👤 Masataka Morishita
- 👤 Yoshihito Inaba
- 👤 Sadami Kobari
- 👤 Mitsuru Fukushima
- 👤 Jinnosuke Abe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5089; A61K9/14; A61K9/16; A61K9/1682; A61K9/1694; B; B01; B01J; B01J13/00; B01J13/02; B01J13/04; B01J13/06; B01J13/12; B01J13/125; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
75 words
DISSOLVING A POLYMER FOR THE CAPSULE''S WALL-FILM SELECTED FROM THE GROUP CONSISTING OF CELLULOSE ACETATE, HYDROXYPROPYL METHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE PHTHALATE, CELLULOSE ACETATE DIBUTYLAMINO HYDROXYPROPYL ETHER, CELLULOSE ACETATE PHTHALATE, HYDROXYETHYL CELLULOSE, HYDROXY PROPYL CELLULOSE, BENZYL CELLULOSE, BENZYL AMINOMETHYL CELLULOSE, DIETHYLAMINO CELLULOSE, POLYACRYLIC ACID ESTER, POLYMETHACRYLIC ACID ESTER, METHYLACRYLATEMETHACRYLIC ACID COPOLYMER, POLYVINYL ACETAL DIETHYLAMINO ACETATE, 2-METHYL-5VINYLPYRIDINE-METHACRYLATE-METHACRYLIC ACID COPOLYMER AND VINYLETHYLAMINO-VINYL ACETATE COPOLYMER IN A SOLVENT HAVING A DIELECTRIC CONSTANT OF FROM 10 TO 40,
Claim 2
Dependent Claim
75 words
DISSOLVING A POLYMER FOR THE CAPSULE''S WALL-FILM SELECTED FROM THE GROUP CONSISTING OF CELLULOSE ACETATE, HYDROXYPROPYL METHYL CELLULOSE, HYDROXY PROPYL METHYL CELLULOSE PHTHALATE, CELLULOSE ACETATE DIBUTYLAMINO HYDROXYPROPYL ETHER, CELLULOSE ACETATE PHTHALATE, HYDROXYETHYL CELLULOSE, HYDROXY PROPYL CELLULOSE, BENZYL CELLULOSE, BENZYL AMINOMETHYL CELLULOSE, DIETHYLAMINO CELLULOSE, POLYACRYLIC ACID ESTER, POLYMETHACRYLIC ACID ESTER, METHYLACRYLATEMETHACRYLIC ACID COPOLYMER, POLYVINYL ACETAL DIETHYLAMINO ACETATE, 2-METHYL-5VINYLPYRIDINE-METHACRYLATE-METHACRYLIC ACID COPOLYMER AND VINYLETHYLAMINO-VINYL ACETATE COPOLYMER IN A SOLVENT HAVING A DIELECTRIC CONSTANT OF FROM 10 TO 40,
Claim 3
Dependent Claim
7 words
A PROCESS FOR PREPARING MICROCAPSULES, WHICH COMPRISES:
Claim 4
Dependent Claim
7 words
A PROCESS FOR PREPARING MICROCAPSULES, WHICH COMPRISES:
Claim 5
Dependent Claim
28 words
EMULSIFYING THE SOLUTION SO PRODUCED IN A VEHICLE WHICH IS A LIQUID PARAFFIN OR A SILICONE OIL, SAID VEHICLE AND SAID SOLVENT BEING POORLY MISCIBLE WITH ONE ANOTHER,
Claim 6
Dependent Claim
28 words
EMULSIFYING THE SOLUTION SO PRODUCED IN A VEHICLE WHICH IS A LIQUID PARAFFIN OR A SILICONE OIL, SAID VEHICLE AND SAID SOLVENT BEING POORLY MISCIBLE WITH ONE ANOTHER,
Claim 7
Dependent Claim
28 words
emulsifying the solution so produced in a vehicle which is a liquid paraffin or a silicone oil, said vehicle and said solvent being poorly miscible with one another,
Claim 8
Dependent Claim
28 words
emulsifying the solution so produced in a vehicle which is a liquid paraffin or a silicone oil, said vehicle and said solvent being poorly miscible with one another,
Claim 9
Dependent Claim
57 words
emulsifying the solution so produced in a vehicle which is a liquid paraffin or a silicone oil, said vehicle and said solvent being substantially immiscible with one another, 3. dispersing into the emulsion so produced with stirring a core substance having a particle size of from 100 to 1,500 Mu and being soluble in said solvent, and
Claim 10
Dependent Claim
57 words
emulsifying the solution so produced in a vehicle which is a liquid paraffin or a silicone oil, said vehicle and said solvent being substantially immiscible with one another, 3. dispersing into the emulsion so produced with stirring a core substance having a particle size of from 100 to 1,500 Mu and being soluble in said solvent, and
Claim 11
Dependent Claim
46 words
emulsifying said solution into at least three times as much by volume of a liquid vehicle comprising paraffin or a silicone oil and containing about 0.1 to 2.0 weight % of a surface active agent and having a viscosity of 10 to 30 c.p.s. at 25*C,
Claim 12
Dependent Claim
46 words
emulsifying said solution into at least three times as much by volume of a liquid vehicle comprising paraffin or a silicone oil and containing about 0.1 to 2.0 weight % of a surface active agent and having a viscosity of 10 to 30 c.p.s. at 25*C,
Claim 13
Dependent Claim
18 words
A process according to claim 1, wherein said solvent is methanol, ethanol, isopropanol, acetone or a mixture thereof.
Claim 14
Dependent Claim
24 words
dispersing a core substance having a particle size of from 100 to 1,500 Mu and being soluble in said solvent in the emulsion, and
Claim 15
Dependent Claim
24 words
dispersing a core substance having a particle size of from 100 to 1,500 Mu and being soluble in said solvent in the emulsion, and
Claim 16
Dependent Claim
40 words
A process according to claim 1, wherein said vehicle is a liquid paraffin, a halogenated paraffin, methyl silicone oil, dimethyl silicone oil, phenyl silicone oil, or methyl phenyl silicone oil having a viscosity of 10 to 30 c.p.s (at 25*C).
Claim 17
Dependent Claim
28 words
dispersing into the emulsion so produced with stirring a core substanCe have a particle size of from 100 to 1,500 Mu and being soluble in said solvent, and
Claim 18
Dependent Claim
28 words
dispersing into the emulsion so produced with stirring a core substanCe have a particle size of from 100 to 1,500 Mu and being soluble in said solvent, and
Claim 19
Dependent Claim
27 words
DISPERSING INTO THE EMULSION SO PRODUCED WITH STIRRING A CORE SUBSTANCE HAVE A PARTICLE SIZE OF FROM 100 TO 1,500U AND BEING SOLUBLE IN SAID SOLVENT, AND
Claim 20
Dependent Claim
27 words
DISPERSING INTO THE EMULSION SO PRODUCED WITH STIRRING A CORE SUBSTANCE HAVE A PARTICLE SIZE OF FROM 100 TO 1,500U AND BEING SOLUBLE IN SAID SOLVENT, AND
Claim 21
Dependent Claim
3 words
EVAPORATING SAID SOLVENT.
Claim 22
Dependent Claim
3 words
EVAPORATING SAID SOLVENT.
Claim 23
Dependent Claim
3 words
evaporating said solvent.
Claim 24
Dependent Claim
3 words
evaporating said solvent.
Claim 25
Dependent Claim
37 words
A process according to claim 1, wherein the concentration of polymer in said solution is about 5 to 20% and the volume ratio of the polymer solution to said vehicle is at least about 1 : 3.
Claim 26
Dependent Claim
3 words
evaporating said solvent.
Claim 27
Dependent Claim
3 words
evaporating said solvent.
Claim 28
Dependent Claim
3 words
evaporating the solvent.
Claim 29
Dependent Claim
3 words
evaporating the solvent.
Claim 30
Dependent Claim
31 words
A process according to claim 1, wherein said core substance is dispersed into said emulsion when the concentration of polymer in the emulsified drops of solution is 20 to 30 W/V%.
Claim 31
Dependent Claim
22 words
A process according to claim 1, wherein said vehicle further includes about 0.1 to 2.0% by weight of a surface active agent.
Claim 32
Dependent Claim
7 words
A process for preparing microcapsules, which comprises:
Claim 33
Dependent Claim
7 words
A process for preparing microcapsules, which comprises:
Claim 34
Dependent Claim
18 words
The process according to claim 7, wherein said solvent is methanol, ethanol, isopropanol, acetone or a mixture thereof.
Claim 35
Dependent Claim
29 words
A process according to claim 7, wherein said vehicle is liquid paraffin a halogenated paraffin, methyl silicone oil, dimethyl silicone oil, phenyl silicone oil or methyl phenyl silicone oil.
Claim 36
Dependent Claim
32 words
A process according to claim 7, wherein said core substance is dispersed into said emulsion when the concentration of a polymer in the emulsified drops of solution is about 20 to 30%.
Claim 37
Dependent Claim
48 words
A process according to claim 7, wherein said cord substance is composed of minute spherical bodies having a diameter of from 100 to 1,500 Mu , each spherical body being formed from a plurality of core material particles having a particle size of less than 100 Mu .
Claim 38
Dependent Claim
7 words
A process for preparing microcapsules, which comprises:
Claim 39
Dependent Claim
7 words
A process for preparing microcapsules, which comprises:
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-01-06 | 1978-07-08 | 1979-01-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-01-06 | 1982-07-08 | 1983-01-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-01-06 | 1986-07-08 | 1987-01-07 | $7700.00 | Window Closed / Lapsed |