US3952741A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release delivery system by an osmotic bursting mechanism
Assignee: Bend Research Inc
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Filing: 1975-01-09
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Granted: 1976-04-27
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Expires: 1995-01-09
Abstract
Abstract An osmotic dispenser comprised of (1) a water permeable membrane forming part or all of the walls of an enclosure surrounding (2) an active agent, and in some cases (3) an additional compound known as an osmotic attractant which together exhibits an osmotic pressure against water. When placed in an aqueous environment water is osmotically drawn into the enclosure by the combined action of the agents (2) and (3) which distends and swells the enclosure until the membrane or some other part of the enclosure wall reaches the point of ultimate elongation and a portion of the wall yields and ruptures releasing the contents of the enclosure to the environment.
Inventors
- 👤 Richard William Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:30
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; B; B65; B65D; B65D65/00; B65D65/38
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
102 words
A water actuated osmatic type active agent dispenser including a means for dispensing a dosage of active agent into an aqueous fluid or humid environment comprising (1) a fluid permable membrane defining at least a part of a walled enclosure, said enclosure containing therein an active agent which exhibits an osmatic pressure upon exposure of the enclosure to the environment, the thickness and permibility of said membrane comprising a means for controlling the water diffusion therethrough until the osmotic pressure in the enclosure is sufficient to distort, stretch and finally rupture the enclosure resulting in release of the agent to the environment.
Claim 2
Dependent Claim
102 words
A water actuated osmatic type active agent dispenser including a means for dispensing a dosage of active agent into an aqueous fluid or humid environment comprising (1) a fluid permable membrane defining at least a part of a walled enclosure, said enclosure containing therein an active agent which exhibits an osmatic pressure upon exposure of the enclosure to the environment, the thickness and permibility of said membrane comprising a means for controlling the water diffusion therethrough until the osmotic pressure in the enclosure is sufficient to distort, stretch and finally rupture the enclosure resulting in release of the agent to the environment.
Claim 3
Dependent Claim
60 words
An osmotic dosage form comprising a plurality of dispensers as set forth in claim 1 wherein said membrane and agent combination is related in a progressive series over a predetermined range such that on prolonged exposure to said aqueous or humid environment the diffusion of water takes place at related varying rates causing the serial bursting of the individual dispensers.
Claim 4
Dependent Claim
20 words
An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is an herbicide.
Claim 5
Dependent Claim
23 words
An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is a pesticide, insecticide or larvicide.
Claim 6
Dependent Claim
20 words
An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is a fertilizer.
Claim 7
Dependent Claim
23 words
An osmotic dispenser as set forth in claim 1 wherein at least a part of the agent is an animal or human medicament.
Claim 8
Dependent Claim
29 words
An osmotic dosage form as set forth in claim 1 wherein at least a part of the agent is a medicament and the aqueous environment is the gastrointestinal fluid.
Claim 9
Dependent Claim
55 words
An osmotic dispenser as set forth in claim 1 wherein a portion of the agent (2) is a biologically or chemically active material and a portion of the agent is an osmotic attractant by means of which the rate of water diffusion into the enclosure and hence subsequent rupture of the enclosure can be regulated.
Claim 10
Dependent Claim
66 words
An osmotic dosage form comprising a plurality of dispensers as set forth in claim 8 wherein the membrane, or the osmotic attractant or a combination of these is related in a progressive series over a predetermined range such that on prolonged exposure to an aqueous or humid environment the diffusion of water takes place at related varying rates causing the serial bursting of the individual dispensers.
Claim 11
Dependent Claim
17 words
An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is an herbicide.
Claim 12
Dependent Claim
20 words
An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is a pesticide, insecticide or larvicide.
Claim 13
Dependent Claim
17 words
An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is a fertilizer.
Claim 14
Dependent Claim
20 words
An osmotic dispenser as set forth in claim 8 wherein the biologically active agent is an animal or human medicament.
Claim 15
Dependent Claim
70 words
An osmotic dispenser as set forth in claim 1 wherein the enclosure wall contains a weak spot or seam which on exposure of the dispenser to the aqueous or humid environment and subsequent imbibition of water causes the enclosure wall to rupture at the weak spot or seam resulting in release of the agent to the environment at a time determined by the strength of the weak spot or seam.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-04-27 | 1979-10-27 | 1980-04-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-04-27 | 1983-10-27 | 1984-04-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-04-27 | 1987-10-27 | 1988-04-27 | $7700.00 | Window Closed / Lapsed |