Drug release system

Claim 2

A body implant device for delivery of a medicament over a long period of time comprising a chamber adapted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completing the surrounding of said chamber, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a water insoluble hydrophilic non toxic biocompatible polymer of a hydroxy lower alkyl acrylate or methacrylate, first conduit means for feeding medicament to said chamber and second conduit means for rapid removal of medicament from said chamber.

Claim 3

A body implant device according to claim 1 including a medicament.

Claim 4

A body implant device according to claim 1 wherein said first and second conduit means both pass throuGh said wall means to said chamber.

Claim 5

A body implant device according to claim 1 having a single membrane means.

Claim 6

A body implant device according to claim 1 having a plurality of spaced apart membrane means.

Claim 7

A body implant device according to claim 1 wherein the hydroxy lower alkyl acrylate or methacrylate is hydroxyethyl methacrylate.

Claim 8

A body implant device according to claim 1 wherein the wall means has a thickness of 2 to 7 mm. and the permeable membrane means has a thickness of 0.1 to 2 mm.

Claim 9

A body implant device according to claim 7 wherein the permeable membrane means is 0.2 to 0.5 mm.

Claim 10

A body implant device according to claim 1 having at least two permeable membrane means of different thicknesses, the rate of fluid transport through the two membrane means being inversely proportional to their thickness.

Claim 11

A body implant device for delivery of a medicament over a long period of time comprising a chamber adopted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough at least partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completely surrounding both said chamber and said wall means, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a biologically incompatible material and an extremely thin coating of a water insoluble hydrophilic non toxic, biocompatible polymer of a hydroxy lower alkyl acrylate or methacrylate surrounding all externally exposed portions of said wall means and said membrane means, said coating being sufficiently thin that it does not interfere with fluid transport through said membrane means, a first conduit means for feeding medicament to said chamber and a second conduit means for rapid removal of medicament from said chamber.

Claim 12

A body implant device for delivery of a medicament over a long period of time comprising a chamber adopted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough at least partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completely surrounding both said chamber and said wall means, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a biologically incompatible material and an extremely thin coating of a water insoluble hydrophilic non toxic, biocompatible polymer of a hydroxy lower alkyl acrylate or methacrylate surrounding all externally exposed portions of said wall means and said membrane means, said coating being sufficiently thin that it does not interfere with fluid transport through said membrane means, a first conduit means for feeding medicament to said chamber and a second conduit means for rapid removal of medicament from said chamber.

Claim 13

A body implant device according to claim 10 including a medicament.

Claim 14

A body implant device according to claim 10 wherein said first and second conduit means both pass through said wall means to said chamber.

Claim 15

A body implant device according to claim 10 wherein said wall means partially surrounds said chamber and said membrane means completes the surrounding of said chamber.

Claim 16

A body implant device according to claim 13 having a single membrane means.

Claim 17

A body implant device according to claim 13 having a plurality of spaced apart membrane means.

Claim 18

A body implant device according to claim 15 having at least two permeable membrane means of different thicknesses the rate of fluid transport through the two membrane means being inversely proportional to their thicknesses.

Claim 19

A body implant device according to claim 10 wherein the hydroxy lower alkyl acrylate or methacrylate is hydroxyethyl methacrylate.

Claim 20

A body implant device according to claim 10 wherein the wall means has a thickness of 2 to 7 mm., the permeable membrane means has a thickness of 0.1 to 2 mm. and the coating has a thickness of 0.01 to 0.1 micron.

Claim 21

A body implant device according to claim 18 wherein the permeable membrane means is 0.2 to 0.5 mm.

Claim 22

A body implant device for delivery of a medicament over a long period of time comprising a chamber adapted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completing the surrounding of said chamber, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a water insoluble hydrophilic non toxic polymer of a member of the group consisting of hydroxy lOwer alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy lower alkyl methacrylates, vinyl pyrrolidone, acrylamide, methacrylamide, N-lower alkyl acrylamide, N-lower alkyl methacrylamide N-hydroxy lower alkyl acrylamide and N-hydroxy lower alkyl methacrylamide first conduit means for feeding medicament to said chamber and second conduit means for rapid removal of medicament from said chamber.

Claim 23

A body implant device for delivery of a medicament over a long period of time comprising a chamber adapted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completing the surrounding of said chamber, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a water insoluble hydrophilic non toxic polymer of a member of the group consisting of hydroxy lOwer alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy lower alkyl methacrylates, vinyl pyrrolidone, acrylamide, methacrylamide, N-lower alkyl acrylamide, N-lower alkyl methacrylamide N-hydroxy lower alkyl acrylamide and N-hydroxy lower alkyl methacrylamide first conduit means for feeding medicament to said chamber and second conduit means for rapid removal of medicament from said chamber.

Claim 24

A body implant device according to claim 20 including a medicament.

Claim 25

A body implant device according to claim 20 wherein said first and second conduit means both pass through said wall means to said chamber.

Claim 26

A body implant device according to claim 20 having a single membrane means.

Claim 27

A body implant device according to claim 23 wherein the wall means and the membrane means are made of a member of the group consisting of hydroxy lower alkyl acrylates and hydroxy lower alkyl methacrylates.

Claim 28

A body implant device according to claim 24 wherein the wall means and the membrane means are made of hydroxy-ethyl methacrylate.

Claim 29

A body implant device according to claim 20 having a plurality of spaced apart membrane means.

Claim 30

A body implant device according to claim 20 wherein the wall means has a thickness of 2 to 7 mm. and the permeable membrane means has a thickness of 0.1 to 2 mm.

Claim 31

A body implant device according to claim 20 wherein the permeable membrane means is 0.2 to 0.5 mm.

Claim 32

A body implant device according to claim 20 having at least two permeable membrane means to different thicknesses, the rate of fluid transport through the two membrane means being inversely proportional to their thickness.

Claim 33

A body implant device for delivery of a medicament over a long period of time comprising a chamber adopted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough at least partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completing the surrounding of said chamber, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a biologically incompatible material and an extremely thin coating of a water insoluble hydrophilic non toxic, biocompatible polymer of a member of the group consisting of hydroxy lower alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy lower alkyl methacrylates, vinyl pyrrolidone, acrylamide, methacrylamide, N-lower alkyl acrylamide, N-lower alkyl methacrylamide, N-hydroxy lower alkyl acrylamide and N-hydroxy lower alkyl methacrylamide surrounding all externally exposed portions of said wall means and said membrane means, said coating being sufficiently thin that it does not interfere with fluid transport through said membrane means, a first conduit means for feeding medicament to said chamber and a second conduit means for rapid removal of medicament from said chamber.

Claim 34

A body implant device for delivery of a medicament over a long period of time comprising a chamber adopted to receive a medicament, body wall means sufficiently thick to be resistant to fluid flow therethrough at least partially surrounding said chamber, relatively thin fluid permeable membrane means engaging said wall means and completing the surrounding of said chamber, said membrane means permitting transport of fluids between the body and said chamber, said membrane means being not over one-half the thickness of said wall means, said wall means and said membrane means being made of a biologically incompatible material and an extremely thin coating of a water insoluble hydrophilic non toxic, biocompatible polymer of a member of the group consisting of hydroxy lower alkyl acrylates, hydroxy lower alkyl methacrylates, hydroxy lower alkoxy lower alkyl acrylates, hydroxy lower alkoxy lower alkyl methacrylates, vinyl pyrrolidone, acrylamide, methacrylamide, N-lower alkyl acrylamide, N-lower alkyl methacrylamide, N-hydroxy lower alkyl acrylamide and N-hydroxy lower alkyl methacrylamide surrounding all externally exposed portions of said wall means and said membrane means, said coating being sufficiently thin that it does not interfere with fluid transport through said membrane means, a first conduit means for feeding medicament to said chamber and a second conduit means for rapid removal of medicament from said chamber.

Claim 35

A body implant device according to claim 30 including a medicament.

Claim 36

A body implant device according to claim 30 wherein said membrane means completely surrounds said wall means.

Claim 37

A body implant device according to claim 30 wherein said wall means partially surrounds said chamber and said membrane means completes the surrounding of said chamber.

Claim 38

A body implant device according to claim 33 having a single membrane means.

Claim 39

A body implant device according to claim 33 having a plurality of spaced apart membrane means.

Claim 40

A body implant device according to claim 35 having at least two permeable membrane means of different thicknesses the rate of fluid transport through the two membrane means being inversely proportional to their thicknesses.

Claim 41

A body implant device according to clAim 30 wherein the wall means has a thickness of 2 to 7 mm., the permeable membrane means has a thickness of 0.1 to 2 mm. and the coating has a thickness of 0.01 to 0.1 micron.

Claim 42

A body implant device according to claim 18 wherein the permeable membrane means is 0.2 to 0.5 mm.