US3857931A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Latex polymer reagents for diagnostic tests
Assignee: F Hoffmann La Roche AG
•
Filing: 1972-01-17
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Granted: 1974-12-31
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Expires: 1992-01-17
Abstract
Abstract Diagnostically useful reagents formed by chemically combining a serologically determinant material to a polymeric carrier particle utilizing a water-soluble monocarbodiimide as a condensing agent as well as diagnostic methods utilizing the reagents are disclosed.
Inventors
- 👤 H Hager
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:33
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/571; G01N33/543; G01N33/54313; Y; Y10; Y10S; Y10S436/00; Y10S436/815; Y10S436/817; Y10S436/818; Y10S530/00; Y10S530/806; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/816; Y10S530/868
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
97 words
A WATER-INSOLUBLE IMMUNOLOGICAL DIAGNOSTIC REAGENT HAVING A SPECIFIC GRAVITY OF ABOUT THAT OF WATER COMPRISING DISCRETE PARTICLES OF A SEROLOGICALLY INERT LATEX POLYMER SELECTED FROM THE GROUP CONSISTING OF CARBOXYLATED STYRENE BUTADIENE, CARBOXYLATE POLYSTYRENE, CARBOXYLATE POLYSTYRENE WITH AMINO GROUPS, ACRYLIC ACID POLYMERS, METHACRYLIC ACDI POLYMERS, ACRYLONITRILE BUTADIENE STYRENE, POLYVINYL ACETATE ACRYLATE, POLYVINYL PYRIDINE AND VINYL-CHORIDE ACRYLATE HAVING CONDENSED THERETO, WITH A WATER SOLUBLE CARBODIIMIDE COUPLING AGENT, THROUGH AN AMIDE LINKAGE, FROM ABOUT 0.01 TO ABOUT 15.0% BY WEIGHT OF A KNOWN SEROLOGICALLY DETERMINANT MATERIAL SELECTED FROM THE GROUP CONSISTING OF HUMAN CHORIONIC GONADOTROPIN AND HUMAN GAMMA GLOBULIN.
Claim 2
Dependent Claim
97 words
A WATER-INSOLUBLE IMMUNOLOGICAL DIAGNOSTIC REAGENT HAVING A SPECIFIC GRAVITY OF ABOUT THAT OF WATER COMPRISING DISCRETE PARTICLES OF A SEROLOGICALLY INERT LATEX POLYMER SELECTED FROM THE GROUP CONSISTING OF CARBOXYLATED STYRENE BUTADIENE, CARBOXYLATE POLYSTYRENE, CARBOXYLATE POLYSTYRENE WITH AMINO GROUPS, ACRYLIC ACID POLYMERS, METHACRYLIC ACDI POLYMERS, ACRYLONITRILE BUTADIENE STYRENE, POLYVINYL ACETATE ACRYLATE, POLYVINYL PYRIDINE AND VINYL-CHORIDE ACRYLATE HAVING CONDENSED THERETO, WITH A WATER SOLUBLE CARBODIIMIDE COUPLING AGENT, THROUGH AN AMIDE LINKAGE, FROM ABOUT 0.01 TO ABOUT 15.0% BY WEIGHT OF A KNOWN SEROLOGICALLY DETERMINANT MATERIAL SELECTED FROM THE GROUP CONSISTING OF HUMAN CHORIONIC GONADOTROPIN AND HUMAN GAMMA GLOBULIN.
Claim 3
Dependent Claim
39 words
The reagent of claim 1 wherein said serologically inert latex polymer is a water insoluble carboxylated styrene butadiene copolymer having a specific gravity of about that of water and a particle size of about 0.01 to about 0.9 microns.
Claim 4
Dependent Claim
14 words
The reagent of claim 1 wherein the serologically determinant material is human chorionic gonadotropin.
Claim 5
Dependent Claim
15 words
The reagent of claim 1 wherein the serologically determinant material is denatured human gamma globulin.
Claim 6
Dependent Claim
43 words
A method of detecting the presence of chorionic gonadotropin in human body fluids which comprises mixing the test fluid with antiserum for chorionic gonadotropin, then contacting the mixture with an aqueous suspension of the water-insoluble reagent of claim 3 and observing the results.
Claim 7
Dependent Claim
34 words
A method of detecting the presence of rheumatoid factor in human body fluids which comprises mixing the test fluid with an aqueous suspension of the water-insoluble reagent of claim 4 and observing the results.
References Cited (Backward Citations)
GB1172768A
Cited
US3639558A
Cited
US3720760A
Cited
US3720760B1
Cited
US3502545A
Cited
US3652761A
Cited
US3709868A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-12-30 | 1978-07-01 | 1978-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-12-30 | 1982-07-01 | 1982-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-12-30 | 1986-07-01 | 1986-12-31 | $7700.00 | Window Closed / Lapsed |