Immunological reagent particles having proteinaceous materials covalently bonded thereto
Abstract
Abstract REACTIVE PARTICLES OF CONTROLLED REACTIVITY AND SIZE WHICH ARE CAPABLE OF DIRECT CHEMICAL ATTACHMENT TO BIOLOGICAL SUBSTANCES CAN BE MADE BY COATING SOLID CARRIER PARTICLES WITH AT LEAST ONE COAT OF A PROTEINACEOUS MATERIAL BY THE USE OF A FIRST COUPLING AGENT AND THEN ATTACHING TO SAID PROTEINACEOUS COAT THROUGH COVALENT BONDING A SECOND COUPLING AGENT CAPABLE OF ATTACHMENT TO BIOLOGICAL SUBSTANCES THROUGH COVALENT BONDING. INSOLUBILZED BIOLOGICAL REAGENTS MAY BE PRODUCED FROM SUCH REACTIVE PARTICLES MERELY BY MIXING THESE PARTICLES WITH BIOLOGICAL SUBSTANCES WHICH WILL BE BOUND THERETO THROUGH THE SECOND COUPLING AGENT. WITH THE USE OF DIFFERENT COUPLING AGENTS VARYING REACTIVITY CAN BE ATTAINED, AND THE DESIRED FINAL PARTICLE SIZE WILL DEPEND UPON THE NUMBER OF COATS OF THE PROTEINACEOUS MATERIAL EMPLOYED.
Inventors
- 👤 Louis Csizmas
- 👤 Virendra Patel
Bibliographic Details
Claims Analysis
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