US3709868A
Expired / Lapsed
US
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Opium alkaloid antigens and antibodies specific therefor
Assignee: F Hoffmann La Roche AG
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Filing: 1971-03-08
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Granted: 1973-01-09
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Expires: 1991-03-08
Abstract
Abstract Opium alkaloid antigens are prepared by coupling opium alkaloid haptens to immunogenic carrier materials. In preferred embodiments proteins are used as carrier materials and the coupling is effected through the carboxyl group of a carboxy lower alkyl derivative of the phenolic hydroxy group of said alkaloid and a free amino group on the protein thereby yielding a covalent peptide bond. The resulting antigens produce immunological effects when injected into host animals, including the formation of opium alkaloid specific antibodies. These specific antibodies are useful in bioanolytical techniques for the assay of opium alkaloids in biological fluids.
Inventors
- 👤 S Spector
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:24
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/94; G01N33/9486; C; C07; C07D; C07D489/00; C07D489/02; Y; Y10; Y10S; Y10S436/00; Y10S436/803; Y10S436/804; Y10S436/815; Y10S436/816; Y10S436/822; Y10S436/823; Y10S436/824; Y10S530/00; Y10S530/806; Y10S530/807
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
12 words
The antigen of claim 1 wherein said opium alkaloid derivative is 3-0-carboxymethylmorphine.
Claim 2
Dependent Claim
12 words
The antigen of claim 1 wherein said protein is bovine serum albumin.
Claim 3
Dependent Claim
21 words
The antigen of claim 3 wherein three to seven opium alkaloid derivative groups are bonded per molecule of bovine serum albumin.
Claim 4
Dependent Claim
42 words
An antigen consisting essentially of a carboxy lower alkyl derivative of the phenolic hydroxyl group of an opium alkaloid bonded through a peptide linkage to an amino group of an immunogenic carrier material selected from the group consisting of proteins and polypeptides.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-01-09 | 1976-07-10 | 1977-01-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-01-09 | 1980-07-10 | 1981-01-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-01-09 | 1984-07-10 | 1985-01-09 | $7700.00 | Window Closed / Lapsed |