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Patent US3742951A successfully refreshed from Google Patents.
US3742951A
Expired / Lapsed
US
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Bandage for controlled release of vasodilators
Assignee: Alza Corp
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Filing: 1971-08-09
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Granted: 1973-07-03
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Expires: 1991-08-09
Abstract
Abstract Medical bandage for use in the continuous administration to circulation of controlled quantities of systemically active coronary vasodilators over a prolonged period of time by absorption through the external body skin or mucosa is comprised of a backing member, a pressure-sensitive adhesive coating, and a reservoir containing the drug confined within a wall member. The wall member is formed from drug release rate controlling material to continuously meter the flow of a therapeutically effective amount of the drug from the reservoir to the skin at a controlled and predetermined rate over a period of time.
Inventors
- 👤 A Zaffaroni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:10
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K9/7084; A61K9/7092
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
147 words
A medical bandage for the continuous administration to the skin or mucosa of controlled quantities of systemically active vasodilator drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising a laminate of (1) a backing member defining one face surface of the bandage; (2) a pressure-sensitive adhesive adapted for contact with the skin or mucosa, the external surface of said pressure-sensitive adhesive defining the other face surface of the bandage and, disposed between the face surfaces defined by (1) and (2); (3) at least one reservoir comprised of a systemically active vasodilator drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time.
Claim 2
Dependent Claim
147 words
A medical bandage for the continuous administration to the skin or mucosa of controlled quantities of systemically active vasodilator drugs over a prolonged period of time by absorption through the external body skin or mucosa, said bandage comprising a laminate of (1) a backing member defining one face surface of the bandage; (2) a pressure-sensitive adhesive adapted for contact with the skin or mucosa, the external surface of said pressure-sensitive adhesive defining the other face surface of the bandage and, disposed between the face surfaces defined by (1) and (2); (3) at least one reservoir comprised of a systemically active vasodilator drug formulation confined within a wall member, said wall member being formed from drug release rate controlling material to continuously meter the flow of drug from the said reservoir to the skin or mucosa at a controlled and predetermined rate over a prolonged period of time.
Claim 3
Dependent Claim
27 words
The bandage as defined by claim 1, wherein said reservoir comprises a discrete, middle reservoir layer sandwiched between said backing member (1) and said pressure-sensitive adhesive (2).
Claim 4
Dependent Claim
28 words
The bandage as defined by claim 2, wherein the reservoir layer is comprised of a walled container having an interior chamber containing the systemically active vasodilator drug formulation.
Claim 5
Dependent Claim
36 words
The bandage as defined by claim 3, wherein only that portion of the walled container which is adapted to be brought contiguous with the skin or mucosa is formed from the drug release rate controlling material.
Claim 6
Dependent Claim
35 words
The bandage as defined by claim 2, wherein the reservoir layer is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active vasodilator drug formulation distributed therethrough.
Claim 7
Dependent Claim
23 words
The bandage as defined by claim 2, further comprising a solubility membrane (4) interposed between said reservoir layer and said pressure-sensitive adhesive (2).
Claim 8
Dependent Claim
26 words
The bandage as defined by claim 2, wherein one outer surface of the wall member comprising the reservoir layer also defines the said backing member (1).
Claim 9
Dependent Claim
23 words
The bandage as defined by claim 1, wherein said reservoir comprises a plurality of discrete microcapsules distributed throughout the said pressure sensitive adhesive.
Claim 10
Dependent Claim
30 words
The bandage as defined by claim 8, wherein each of said microcapsules is comprised of systemically active vasodilator drug formulation microencapsulated with the said drug release rate controlling wall material.
Claim 11
Dependent Claim
36 words
The bandage as defined by claim 8, wherein each of said microcapsules is comprised of a matrix of the drug release rate controlling wall material, said matrix having the systemically active vasodilator drug formulation distributed therethrough.
Claim 12
Dependent Claim
22 words
The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is permeable to passage of the systemically active vasodilator drug formulation.
Claim 13
Dependent Claim
17 words
The bandage as defined by claim 1, wherein the vasodilator drug formulation comprises a pharmacologically acceptable solvent.
Claim 14
Dependent Claim
17 words
The bandage as defined by claim 1, wherein said drug release rate controlling material is silicone rubber.
Claim 15
Dependent Claim
25 words
The bandage as defined by claim 1, wherein said drug release rate controlling material is a hydrophilic polymer of an ester of an olefinic acid.
Claim 16
Dependent Claim
18 words
The bandage as defined by claim 1, wherein the pressure-sensitive adhesive is covered with a protective release coating.
Claim 17
Dependent Claim
22 words
The bandage as defined by claim 1, wherein the outer surface of the backing member is coated with a low adhesion backsize.
Claim 18
Dependent Claim
12 words
The bandage as defined by claim 1, wherein the vasodilator is nitroglycerin.
Claim 19
Dependent Claim
26 words
The bandage as defined by claim 1, wherein the organic nitrate vasodilator is present in an amount of from about 1 microgram to about 1 gram.
Claim 20
Dependent Claim
27 words
The method of effecting vasodilation in a mammalian organism, comprising direct application to the skin or mucosa of such organism, the bandage as defined by claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-07-02 | 1977-01-01 | 1977-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-07-02 | 1981-01-01 | 1981-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-07-02 | 1985-01-01 | 1985-07-03 | $7700.00 | Window Closed / Lapsed |