Patent GB191116595A successfully refreshed from Google Patents.
US20040210304A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prosthetic valve for transluminal delivery
Assignee: CoreValve SA
•
Filing: 2004-02-04
•
Granted: —
•
Expires: 2024-02-04
Abstract
Abstract A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchors may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. Portions of the valve support may expand to a preset diameter to maintain coaptivity of the replacement valve and to prevent occlusion of the coronary ostia. A radial restraint, comprising a wire, thread or cuff, may be used to ensure expansion does not exceed the preset diameter. The valve support may optionally comprise a drug elution component. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. A blood pump may be inserted into the catheter to ensure continued blood flow across the implantation site during implantation procedure. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand at the implantation site and the anchor engages the lumen wall. Insertion of the catheter may optionally be performed over a transseptally delivered guidewire that has been externalized through the arterial vasculature. Such a guidewire provide dual venous and arterial access to the implantation site and allows additional manipulation of the implantation site after arterial implantation of the prosthetic valve. Additional expansion stents may be delivered by venous access to the valve.
Inventors
- 👤 Jacques Seguin
- 👤 Georg Bortlein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:46
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2409; A61F2/01; A61F2/013; A61F2/2412; A61F2/2418; A61F2/2427; A61F2/243; A61F2/2433; A61F2/2436; A61F2/82; A61F2/86; A61F2/90; A61F2/91; A61F2/915; A61B; A61B17/00; A61B17/02; A61B17/0218; A61F2/92; A61F2/93; A61F2002/9155; A61F2002/91558; A61F2002/91591; A61F2210/00; A61F2210/0014; A61F2210/0023; A61F2220/00; A61F2220/0008; A61F2220/0016; A61F2220/0025; A61F2220/005; A61F2220/0058; A61F2220/0075; A61F2230/00; A61F2230/0002; A61F2230/0028; A61F2230/005; A61F2230/0054; A61F2230/0063; A61F2230/0067; A61F2230/0073; A61F2230/0078; A61F2250/00; A61F2250/0003; A61F2250/0014; A61F2250/0039; A61F2250/0048; A61F2250/0058; A61F2250/0069
Claims Analysis
Total Claims: 85
Claim 1
Independent Claim
88 words
1 . A prosthetic valve assembly for use in replacing a deficient native valve, the valve assembly comprising: a valve having a plurality of resilient leaflets; a valve support configured to be collapsible for transluminal delivery and comprising a first and a second portion, said first portion expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned, said second portion supporting the base and the commissure points of the valve; and a radial restraint for controlling a diameter of the second portion.
Claim 2
Dependent Claim
88 words
1 . A prosthetic valve assembly for use in replacing a deficient native valve, the valve assembly comprising: a valve having a plurality of resilient leaflets; a valve support configured to be collapsible for transluminal delivery and comprising a first and a second portion, said first portion expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned, said second portion supporting the base and the commissure points of the valve; and a radial restraint for controlling a diameter of the second portion.
Claim 3
Dependent Claim
23 words
2 . The valve assembly of claim 1 , wherein the radial restraint is capable of substantially resisting expansion beyond a preset diameter.
Claim 4
Dependent Claim
23 words
3 . The valve assembly of claim 1 , wherein the radial restraint is capable of substantially resisting collapse below a preset diameter.
Claim 5
Dependent Claim
31 words
4 . The valve assembly of claim 1 , wherein the radial restraint is capable of substantially resisting expansion beyond a preset diameter and substantially resisting collapse below a preset diameter.
Claim 6
Dependent Claim
16 words
5 . The valve assembly of claim 1 , wherein the radial restraint comprises a wire.
Claim 7
Dependent Claim
16 words
6 . The valve assembly of claim 1 , wherein the radial restraint comprises a thread.
Claim 8
Dependent Claim
17 words
7 . The valve assembly of claim 1 , wherein the radial restraint comprises a mechanical stop.
Claim 9
Dependent Claim
39 words
8 . The valve assembly of claim 1 , wherein the radial restraint comprises material from which at least a portion of the valve support is made so that the second portion does not expand beyond a preset diameter.
Claim 10
Dependent Claim
16 words
9 . The valve assembly of claim 8 , wherein the material comprise shape memory material.
Claim 11
Dependent Claim
16 words
10 . The valve assembly of claim 1 , wherein the radial restraint comprises a cuff.
Claim 12
Dependent Claim
29 words
11 . The valve assembly of claim 1 , wherein the radial restraint comprises a stent configured to cooperate with the valve support so as to substantially preclude recoil.
Claim 13
Dependent Claim
14 words
12 . The valve assembly of claim 1 , further comprising a drug-eluting component.
Claim 14
Dependent Claim
32 words
13 . The valve assembly of claim 1 , further comprising an anchor for engaging the lumen wall when expanded in place for preventing substantial migration of the valve assembly after deployment.
Claim 15
Dependent Claim
18 words
14 . The valve assembly of claim 1 , wherein the valve support comprises at least one wire.
Claim 16
Dependent Claim
19 words
15 . The valve assembly of claim 14 , wherein the valve support comprises a single length of wire.
Claim 17
Dependent Claim
30 words
16 . The valve assembly of claim 14 , wherein at least one portion of the single length of wire has a reduced thickness to decrease the radial expansion force.
Claim 18
Dependent Claim
129 words
17 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support permitting attachment thereto of the base and the commissures of the valve, and an anchor for engaging the lumen wall when expanded for preventing substantial migration of the valve assembly when positioned in place; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 19
Dependent Claim
129 words
17 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support permitting attachment thereto of the base and the commissures of the valve, and an anchor for engaging the lumen wall when expanded for preventing substantial migration of the valve assembly when positioned in place; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 20
Dependent Claim
30 words
18 . The method of claim 17 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the first vascular access site.
Claim 21
Dependent Claim
30 words
19 . The method of claim 17 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the second vascular access site.
Claim 22
Dependent Claim
22 words
20 . The method of claim 17 , further comprising the step of advancing a blood pump across the deficient native valve.
Claim 23
Dependent Claim
23 words
21 . The method of claim 20 , wherein the step of advancing the catheter comprises advancing the catheter over the blood pump.
Claim 24
Dependent Claim
27 words
22 . The method of claim 20 , wherein the step of advancing the blood pump comprises inserting the blood pump across the first vascular access site.
Claim 25
Dependent Claim
27 words
23 . The method of claim 20 , wherein the step of advancing the blood pump comprises inserting the blood pump across the second vascular access site.
Claim 26
Dependent Claim
42 words
24 . The method of claim 18 , further comprising the steps of: advancing a stent from the second vascular access site to the deficient valve; deploying the stent to substantially preclude any portion of the native valve from obstructing blood flow.
Claim 27
Dependent Claim
16 words
25 . The method of claim 17 , wherein the valve support and anchor are self-expanding.
Claim 28
Dependent Claim
29 words
26 . The method of claim 25 , further comprising the step of restraining self-expansion of the valve support to a preset diameter by at least one radial restraint
Claim 29
Dependent Claim
24 words
27 . The method of claim 17 , wherein the valve assembly further comprises loop elements for releasably attaching the anchor to the catheter.
Claim 30
Dependent Claim
20 words
28 . The method of claim 17 , wherein the catheter comprises a filter for catching emboli or valve fragments.
Claim 31
Dependent Claim
15 words
29 . The method of claim 17 , wherein the catheter comprises an over-the-wire catheter.
Claim 32
Dependent Claim
16 words
30 . The method of claim 17 , wherein the catheter comprises a rapid exchange catheter.
Claim 33
Dependent Claim
106 words
31 . A prosthetic valve assembly configured for endoluminal delivery to replace a deficient native valve, the valve assembly comprising an axial valve support portion configured to support a prosthetic valve having at least one leaflet and to prevent substantial interference with the positioning and/or operation of the prosthetic valve by any residual components of the native valve, including calcified native components, said support portion comprising at least one radial restraint at a first section of said support portion to preclude expansion when deployed in situ substantially no greater than a preset diameter to increase coaptivity of the prosthetic valve leaflets and to prevent significant regurgitation.
Claim 34
Dependent Claim
106 words
31 . A prosthetic valve assembly configured for endoluminal delivery to replace a deficient native valve, the valve assembly comprising an axial valve support portion configured to support a prosthetic valve having at least one leaflet and to prevent substantial interference with the positioning and/or operation of the prosthetic valve by any residual components of the native valve, including calcified native components, said support portion comprising at least one radial restraint at a first section of said support portion to preclude expansion when deployed in situ substantially no greater than a preset diameter to increase coaptivity of the prosthetic valve leaflets and to prevent significant regurgitation.
Claim 35
Dependent Claim
18 words
32 . The valve assembly of claim 31 , wherein the radial restraint is configured to reduce recoil.
Claim 36
Dependent Claim
17 words
33 . The valve assembly of claim 31 , wherein the radial restraint comprises a mechanical stop.
Claim 37
Dependent Claim
37 words
34 . The valve assembly of claim 31 , wherein the support portion further comprises a second section configured to expand in situ for pushing the residual native valve components against the native annulus and surrounding tissue.
Claim 38
Dependent Claim
27 words
35 . The valve assembly of claim 34 , wherein the second section is configured to expand to a diameter different from that of the first section.
Claim 39
Dependent Claim
22 words
36 . The valve assembly of claim 34 , wherein said second section is configured to be expanded by a balloon catheter.
Claim 40
Dependent Claim
24 words
37 . The valve assembly of claim 36 , wherein said second section is configured to be expanded beyond its yield point in situ.
Claim 41
Dependent Claim
26 words
38 . The valve assembly of claim 31 , further comprising a stent configured to expand in situ for pushing against the residual native valve components.
Claim 42
Dependent Claim
14 words
39 . The valve assembly of claim 38 , wherein the stent is self-expanding.
Claim 43
Dependent Claim
21 words
40 . The valve assembly of claim 38 , wherein the stent is configured to be expanded by a balloon catheter.
Claim 44
Dependent Claim
28 words
41 . The valve assembly of claim 31 , further comprising a stent configured to reduce the recoil of the support portion following self-expansion of the support portion.
Claim 45
Dependent Claim
23 words
42 . The valve assembly of claim 38 , wherein the stent is configured to reside within the valve support portion when deployed.
Claim 46
Dependent Claim
23 words
43 . The valve assembly of claim 38 , wherein the stent is configured to reside outside the valve support portion when deployed.
Claim 47
Dependent Claim
29 words
44 . The valve assembly of claim 31 , further comprising at least one anchor configured to exert sufficient radial forces against the lumen wall to prevent substantial migration.
Claim 48
Dependent Claim
16 words
45 . The valve assembly of claim 31 , wherein said radial restraint comprises a wire.
Claim 49
Dependent Claim
16 words
46 . The valve assembly of claim 31 , wherein said radial restraint comprises a thread.
Claim 50
Dependent Claim
16 words
47 . The valve assembly of claim 31 , wherein said radial restraint comprises a cuff.
Claim 51
Dependent Claim
138 words
48 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support comprising a first valve support section permitting attachment thereto of the base and the commissures of the valve, and a second valve support section configured to expand in situ to push the residual native valve components against the native annulus and surrounding tissue; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 52
Dependent Claim
138 words
48 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support comprising a first valve support section permitting attachment thereto of the base and the commissures of the valve, and a second valve support section configured to expand in situ to push the residual native valve components against the native annulus and surrounding tissue; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 53
Dependent Claim
30 words
49 . The method of claim 48 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the first vascular access site.
Claim 54
Dependent Claim
30 words
50 . The method of claim 48 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the second vascular access site.
Claim 55
Dependent Claim
22 words
51 . The method of claim 48 , further comprising the step of advancing a blood pump across the deficient native valve.
Claim 56
Dependent Claim
23 words
52 . The method of claim 51 , wherein the step of advancing the catheter comprises advancing the catheter over the blood pump.
Claim 57
Dependent Claim
27 words
53 . The method of claim 51 , wherein the step of advancing the blood pump comprises inserting the blood pump across the first vascular access site.
Claim 58
Dependent Claim
27 words
54 . The method of claim 51 , wherein the step of advancing the blood pump comprises inserting the blood pump across the second vascular access site.
Claim 59
Dependent Claim
42 words
55 . The method of claim 48 , further comprising the steps of: advancing a stent from the second vascular access site to the deficient valve; deploying the stent to substantially preclude any portion of the native valve from obstructing blood flow.
Claim 60
Dependent Claim
14 words
56 . The method of claim 48 , wherein the valve support is self-expanding.
Claim 61
Dependent Claim
32 words
57 . The method of claim 56 , further comprising the step of restraining self-expansion of a portion of the valve support to a preset diameter by at least one radial restraint
Claim 62
Dependent Claim
24 words
58 . The method of claim 49 , wherein the valve assembly further comprises loop elements for releasably attaching the anchor to the catheter.
Claim 63
Dependent Claim
20 words
59 . The method of claim 48 , wherein the catheter comprises a filter for catching emboli or valve fragments.
Claim 64
Dependent Claim
15 words
60 . The method of claim 48 , wherein the catheter comprises an over-the-wire catheter.
Claim 65
Dependent Claim
16 words
61 . The method of claim 48 , wherein the catheter comprises a rapid exchange catheter.
Claim 66
Dependent Claim
123 words
62 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support permitting attachment thereto of the base and the commissures of the valve, and a radial restraint controlling a diameter of at least a portion of the valve assembly; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 67
Dependent Claim
123 words
62 . A method of replacing a deficient native valve comprising the steps of: providing a prosthetic valve assembly, the assembly comprising a valve, a valve support permitting attachment thereto of the base and the commissures of the valve, and a radial restraint controlling a diameter of at least a portion of the valve assembly; collapsing the valve support to fit within a distally positioned sheath on a catheter; inserting a guidewire into a vascular access site; externalizing at least a portion of the guidewire through a second vascular access site; advancing the catheter over the guidewire to the deficient native valve; deploying the valve assembly; and withdrawing the catheter, leaving the valve assembly to function in place of the deficient native valve.
Claim 68
Dependent Claim
30 words
63 . The method of claim 62 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the first vascular access site.
Claim 69
Dependent Claim
30 words
64 . The method of claim 62 , wherein the step of advancing the catheter comprises advancing the catheter to the deficient native valve from the second vascular access site.
Claim 70
Dependent Claim
22 words
65 . The method of claim 62 , further comprising the step of advancing a blood pump across the deficient native valve.
Claim 71
Dependent Claim
23 words
66 . The method of claim 65 , wherein the step of advancing the catheter comprises advancing the catheter over the blood pump.
Claim 72
Dependent Claim
27 words
67 . The method of claim 65 , wherein the step of advancing the blood pump comprises inserting the blood pump across the first vascular access site.
Claim 73
Dependent Claim
27 words
68 . The method of claim 65 , wherein the step of advancing the blood pump comprises inserting the blood pump across the second vascular access site.
Claim 74
Dependent Claim
42 words
69 . The method of claim 64 , further comprising the steps of: advancing a stent from the second vascular access site to the deficient valve; deploying the stent to substantially preclude any portion of the native valve from obstructing blood flow.
Claim 75
Dependent Claim
14 words
70 . The method of claim 62 , wherein the valve support is self-expanding.
Claim 76
Dependent Claim
24 words
71 . The method of claim 62 , wherein the valve assembly further comprises loop elements for releasably attaching the anchor to the catheter.
Claim 77
Dependent Claim
20 words
72 . The method of claim 62 , wherein the catheter comprises a filter for catching emboli or valve fragments.
Claim 78
Dependent Claim
15 words
73 . The method of claim 62 , wherein the catheter comprises an over-the-wire catheter.
Claim 79
Dependent Claim
16 words
74 . The method of claim 62 , wherein the catheter comprises a rapid exchange catheter.
Claim 80
Dependent Claim
29 words
75 . A prosthetic valve assembly configured for endoluminal delivery to replace a deficient native valve, the valve assembly comprising a non-cylindrical valve support and at least one anchor.
Claim 81
Dependent Claim
29 words
75 . A prosthetic valve assembly configured for endoluminal delivery to replace a deficient native valve, the valve assembly comprising a non-cylindrical valve support and at least one anchor.
Claim 82
Dependent Claim
80 words
76 . A method of replacing a deficient heart valve comprising the steps of: delivering to a target native valve site a valve prosthesis comprising a first portion and a second portion, the first portion limited in its expansion diameter when compared to the second portion; delivering a perfusion pump to the desired target site to pump blood through the target site during application of the valve prosthesis; and deploying the valve prosthesis while pumping blood through the target site.
Claim 83
Dependent Claim
80 words
76 . A method of replacing a deficient heart valve comprising the steps of: delivering to a target native valve site a valve prosthesis comprising a first portion and a second portion, the first portion limited in its expansion diameter when compared to the second portion; delivering a perfusion pump to the desired target site to pump blood through the target site during application of the valve prosthesis; and deploying the valve prosthesis while pumping blood through the target site.
Claim 84
Dependent Claim
17 words
77 . The method of claim 76 , wherein the valve prosthesis further comprises a radial restraint.
Claim 85
Dependent Claim
16 words
78 . The method of claim 76 , wherein the valve prosthesis further comprises an anchor.
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