US20040023387A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of making demineralized bone particles
Assignee: Warsaw Orthopedic Inc
•
Filing: 2001-12-14
•
Granted: —
•
Expires: 2021-12-14
Abstract
Abstract Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
Inventors
- 👤 John Morris
- 👤 Lawrence Shimp
- 👤 Kenneth Petersen
- 👤 Albert Manrique
- 👤 David Kaes
- 👤 Nelson Scarborough
- 👤 Michael Dowd
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/32; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/46; A61F2/4644; A61K45/00; A61K45/06; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/3683; A61L27/3691; A61L27/3695; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F2002/4645; A61L2430/00; A61L2430/40
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
24 words
1 . A method of making demineralized bone particles which comprises demineralizing whole bone and thereafter subdividing the demineralized bone into demineralized bone particles.
Claim 2
Dependent Claim
24 words
1 . A method of making demineralized bone particles which comprises demineralizing whole bone and thereafter subdividing the demineralized bone into demineralized bone particles.
Claim 3
Dependent Claim
40 words
2 . The method of claim 1 wherein the yield of demineralized bone particles is greater than that obtained by subdividing the whole bone into mineralized bone particles and thereafter demineralizing the mineralized bone particles to provide demineralized bone particles.
Claim 4
Dependent Claim
22 words
3 . The method of claim 1 in which the whole bone is autogenic, allogenic or xenogenic cortical, cancellous or corticoncancellous bone.
Claim 5
Dependent Claim
23 words
4 . The method of claim 1 wherein the whole bone is demineralized to contain less than about 10% by weight residual calcium.
Claim 6
Dependent Claim
23 words
5 . The method of claim 1 wherein the whole bone is demineralized to contain less than about 5% by weight residual calcium.
Claim 7
Dependent Claim
23 words
6 . The method of claim 1 wherein the whole bone is demineralized to contain less than about 1% by weight residual calcium.
Claim 8
Dependent Claim
18 words
7 . The method of claim 1 wherein subdividing of the demineralized bone is carried out by milling.
Claim 9
Dependent Claim
23 words
8 . The method of claim 7 wherein milling is carried out in an impact mill, a grating mill or a cutting mill.
Claim 10
Dependent Claim
24 words
9 . The method of claim 1 wherein subdividing of the demineralized bone is carried out by applying mechanical pressure to the demineralized bone.
Claim 11
Dependent Claim
16 words
10 . The method of claim 9 wherein the bone is subjected to pressing while unconstrained.
Claim 12
Dependent Claim
16 words
11 . The method of claim 9 wherein the bone is subjected to pressing while constrained.
Claim 13
Dependent Claim
20 words
12 . The method of claim 9 carried out under a pressure of from about 1,000 to about 40,000 psi.
Claim 14
Dependent Claim
20 words
13 . The method of claim 9 carried out under a pressure of from about 5,000 to about 20,000 psi.
Claim 15
Dependent Claim
20 words
14 . The method of claim 10 wherein the product of pressing is subjected to an additional pressing while constrained.
Claim 16
Dependent Claim
19 words
15 . The method of claim 9 wherein the product of pressing is subjected to an additional subdividing operation.
Claim 17
Dependent Claim
43 words
16 . The method of claim 1 wherein the whole bone ranges from about 1 to about 400 mm in median length, from about 0.5 to about 20 mm in median thickness and from about 2 to about 10 mm in median width.
Claim 18
Dependent Claim
44 words
17 . The method of claim 1 wherein the whole bone ranges from about 5 to about 100 mm in median length, from about 2 to about 10 mm in median thickness and from about 2 mm to about 10 mm in median width.
Claim 19
Dependent Claim
16 words
18 . The method of claim 1 wherein the demineralized bone particles are of elongated configuration.
Claim 20
Dependent Claim
72 words
19 . The method of claim 18 wherein the demineralized bone particles possess a median length of from about 2 to about 300 mm, a median thickness and/or a median width of from about 0.5 mm to about 15 mm, a median width of from about 2 to about 35 mm and a median length to thickness ratio and/or a median length to width ratio of from about 2 to about 200.
Claim 21
Dependent Claim
67 words
20 . The method of claim 18 wherein the demineralized bone particles possess a median length of from about 5 to about 50 mm, a median thickness of from about 1 to about 5 mm, a median width of from about 2 to about 20 mm and/or a median length to thickness ratio and/or a median length to width ratio of from about 10 to about 100.
Claim 22
Dependent Claim
13 words
21 . Demineralized bone fibers produced by the process of claim 9 .
Claim 23
Dependent Claim
8 words
22 . Substantially intact natural bone collagen fibers.
Claim 24
Dependent Claim
8 words
22 . Substantially intact natural bone collagen fibers.
Claim 25
Dependent Claim
34 words
23 . The bone collagen fibers of claim 22 having a length substantially equivalent to the length of the fibers as they were present in the demineralized bone from which the fibers were obtained.
Claim 26
Dependent Claim
17 words
24 . The demineralized bone fibers of claim 21 containing at least one added medically/surgically useful substance.
Claim 27
Dependent Claim
17 words
25 . The bone collagen fibers of claim 22 containing at least one added medically/surgically useful substance
References Cited (Backward Citations)
US5053049A
Cited
US6311690B1
Cited
US4743259A
Cited
US4902296A
Cited
US5073373A
Cited
US5298254A
Cited
US5314476A
Cited
US5507813A
Cited
US5607269A
Cited
US5846484A
Cited
US20020107570A1
Cited
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.