EP0756853A1
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Composite metal and polymer locking stents for drug delivery
Assignee: Abbott Cardiovascular Systems Inc
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Filing: 1996-06-24
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Granted: —
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Expires: 2016-06-24
Abstract
Abstract The composite locking stent (10) includes a metal structural member (12) laminated between two layers (24) of a polymeric material capable of carrying and delivering therapeutic drugs. The metal and polymer components are incorporated into a rolled locking design. The head end (16) includes a slot (22) for receipt of the tail end (20), so that the tail end and main body portion are insertable through the slot so as to form a cylindrical loop. The tail end preferably includes a plurality of teeth (23) adapted to cooperatively engage the slot of the head end for retaining the tail end when inserted in the slot. The metal structural member can function as the mechanical structural backbone and a radio-opaque visualization marker, or with a polymeric material sufficiently strong to provide the structural strength required for a stent, the metal structural member can simply be provided to function as a radio-opaque visualization marker.
Inventors
- 👤 Michael S. Williams
- 👤 Patrick K. Campbell
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 14:26
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/08; A61L31/10; A61F; A61F2/00; A61F2/82; A61F2/92; A61F2/93; A61L31/14; A61L31/16; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2250/0096; A61F2250/0098; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/42
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
210 words
A composite locking stent, comprising: a proximal head end portion; at least one elongated main body portion connected to said head end portion, said at least one main body portion extending distally from said head end portion, each said main body portion having a tail end portion opposing said head end portion; at least one elongated slot disposed in said head end portion extending transversely to said elongated main body portion, each said tail end portion being adapted to interlock with said head end portion through a corresponding one of said slots in said head end portion; and metal structural means disposed in at least a portion of one of said head end portion and said at least one main body portion for providing structural support to said composite locking stent, said metal structural means being disposed between first and second layers of polymeric material laminated together, said first and second layers of polymeric material forming an exterior portion of said head end portion and said at least one main body portion, and at least one of said layers of polymeric material being capable of being loaded with and releasing therapeutic agents at a predictable rate for delivery of the therapeutic agents in localized drug therapy in a blood vessel.
Claim 2
Dependent Claim
27 words
The composite locking stent of Claim 1, wherein said metal structural means comprises a planar metal structural member providing the structural support in said head end portion.
Claim 3
Dependent Claim
36 words
The composite locking stent of Claim 1, wherein said metal structural means comprises a planar metal structural member providing the structural support in said head end portion and in said at least one main body portion.
Claim 4
Dependent Claim
60 words
The composite locking stent of Claim 3, wherein each said planar metal structural member disposed in said tail end portion of said at least one main body portion comprises peripheral edges having a plurality of teeth directed outward from said tail end portion and distally from said head end portion for engaging said corresponding slot in said head end portion.
Claim 5
Dependent Claim
28 words
The composite locking stent of Claim 1, wherein said metal structural member in said at least one main body portion has a surface defining at least one aperture.
Claim 6
Dependent Claim
102 words
A composite stent, comprising: a first layer of polymeric material; a second layer of a planar metal structural member providing structural support for said composite stent, said second layer having a first side and a second side, and said first layer of polymeric material being laminated to said first side of said second layer; and a third layer of polymeric material laminated to said second side of said second layer, at least one of said layers of polymeric material being loaded with at least one therapeutic agent to be delivered at a predictable rate in localized drug therapy in a blood vessel.
Claim 7
Dependent Claim
63 words
The composite stent of Claim 6, wherein at least one of said layers defines a proximal head end portion and at least one elongated main body portion connected to said head end portion, said at least one main body portion extending distally from said head end portion, each said elongated main body portion having a tail end portion opposing said head end portion.
Claim 8
Dependent Claim
34 words
The composite stent of Claim 7, wherein said second layer of said planar metal structural member comprises provides structural support in said head end portion and in said at least one main body portion.
Claim 9
Dependent Claim
18 words
The composite stent of Claim 1 or Claim 6, wherein said metal structural means comprises a radio-opaque marker.
Claim 10
Dependent Claim
40 words
The composite stent of Claim 1 or Claim 6, wherein at least one of said first and second layers of polymeric material is selected from the group consisting of polycaprolactone, poly-DL-lactic acid, poly-L-lactic acid, polyorthoesters, polyiminocarbonates, aliphatic polycarbonates, and polyphosphazenes.
Claim 11
Dependent Claim
38 words
The composite stent of Claim 1 or Claim 6, wherein at least one of said layers of polymeric material contains a therapeutic agent selected from the group consisting of antiplatelets, antithrombins, cytostatic and antiproliferative agents, and combinations thereof.
Claim 12
Dependent Claim
109 words
The composite stent of Claim 1 or Claim 6, wherein at least one of said layers of polymeric material contains a therapeutic agent selected from the group consisting of sodium heparin, low molecular weight heparin, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone, dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antibody, recombinant hirudin, thrombin inhibitor, angiopeptin, angiotensin converting enzyme inhibitors, or Lisinopril; calcium channel blockers, colchicine, fibroblast growth factor antagonists, fish oil, omega 3-fatty acid, histamine antagonists, HMG-CoA reductase inhibitor, methotrexate, monoclonal antibodies, nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitor, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine and other PDGF antagonists, alpha-interferon, genetically engineered epithelial cells, nitric oxide, and combinations thereof.
Claim 13
Dependent Claim
34 words
The composite stent of Claim 7, wherein said second layer of said metal structural member is disposed in said at least one main body portion and has a surface defining at least one aperture.
Claim 14
Dependent Claim
48 words
The composite stent of Claim 5 or Claim 13, wherein said at least one aperture is filled in by said layers of polymeric material, and said layers of polymeric material have a surface defining a plurality of apertures through said polymeric material and said at least one aperture.
Claim 15
Dependent Claim
17 words
The composite stent of Claim 1 or Claim 6, wherein said layers of polymeric material are bioabsorbable.
Claim 16
Dependent Claim
53 words
The composite stent of Claim 7, wherein at least one elongated slot is disposed in said head end portion extending transversely to said elongated main body portion, each said tail end portion being adapted to interlock with said head end portion through a corresponding one of said slots in said head end portion.
Claim 17
Dependent Claim
55 words
The composite stent of Claim 1 or Claim 16, wherein each said tail end portion of said at least one main body portion comprises peripheral edges having a plurality of teeth directed outward from said tail end portion and distally from said head end portion for engaging said corresponding slot in said head end portion.
Claim 18
Dependent Claim
69 words
The composite stent of Claim 17 when dependent upon Claim 16, wherein said second layer of said planar metal structural member comprises is disposed in said tail end portion of said at least one main body portion having peripheral edges with a plurality of teeth directed outward from said tail end portion and distally from said head end portion for engaging said corresponding slot in said head end portion.
Claim 19
Dependent Claim
27 words
The composite stent of Claim 17 when dependent upon Claim 16, wherein said plurality of teeth are formed by said first and third layers of polymeric material.
Claim 20
Dependent Claim
28 words
The composite locking stent of Claim 16 when dependent upon Claim 1, wherein said plurality of teeth are formed by said first and second layers of polymeric material.
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FR2694688A1
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EP0604022A1
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WO1994021196A2
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