EP0645150A1
Expired / Lapsed
EP
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Medical devices subject to triggered disintegration
Assignee: Boston Scientific Ltd Barbados
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Filing: 1994-09-29
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Granted: —
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Expires: 2014-09-29
Abstract
Abstract The present invention provides medical devices comprised of ionically crosslinked polymer, especially, stents, catheter or cannula components, plugs, and constrictors. The medical devices of the present invention are prepared by treatment of ionically crosslinkable polymer compositions with crosslinking ion compositions to provide ionically crosslinked materials. An important aspect of the present invention is that these medical devices can be disintegrated in-vivo at a desired time through the exposure of the medical device to a chemical trigger which generally is described as an agent that acts to displace the crosslinking ion in the ionically crosslinked material through binding or simple replacement with a non-crosslinking ion.
Inventors
- 👤 Gary Andrew Luzio
- 👤 Samuel Anthony Thompson
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:00
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/148; A61L29/00; A61L29/14; A61L29/148; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2987
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
37 words
A medical device characterized in that it comprises at least one ionically crosslinked polymer, the polymer being disintegrateable by a pharmaceutically acceptable trigger, with the proviso that devices for use in adhesion prevention, following surgery, are disclaimed.
Claim 2
Dependent Claim
22 words
A medical device according to claim 1, comprising at least one member selected from stents, catheter or cannula components, plugs and constrictors.
Claim 3
Dependent Claim
38 words
The medical device of claims 1 or 2 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of carboxylic, sulfate and amine functionalized polymers.
Claim 4
Dependent Claim
27 words
The medical device of any one of claims 1 to 3 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one polysaccharide.
Claim 5
Dependent Claim
30 words
The medical device of any one of claims 1 to 4 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable anionic polymer.
Claim 6
Dependent Claim
30 words
The medical device of any one of claims 1 to 5 wherein said ionically crosslinked polymer comprises at least one polymer made from at least one ionically crosslinkable cationic polymer.
Claim 7
Dependent Claim
57 words
The medical device of claim 5 wherein said ionically crosslinked anionic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxyl methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 8
Dependent Claim
39 words
The medical device of claim 6 wherein said ionically crosslinked cationic polymer comprises at least one polymer made from at least one ionically crosslinkable polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 9
Dependent Claim
30 words
The medical device of any one of claims 1 to 5 and 7 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises one or more cations.
Claim 10
Dependent Claim
33 words
The medical device of claim 9 wherein said one or more cations are selected from the group consisting of calcium, magnesium, barium, strontium, boron, berylium, aluminum, iron, copper, cobalt, lead, and silver ions.
Claim 11
Dependent Claim
31 words
The medical device of any one of claims 1 to 4, 6 and 8 wherein said ionically crosslinked polymer is crosslinked by a crosslinking ion which comprises one or more anions.
Claim 12
Dependent Claim
28 words
The medical device of claim 11 wherein said one or more anions are selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 13
Dependent Claim
29 words
The medical device of any one of the preceding claims further comprising at least one body fluid selected from the group consisting of urine, bile, feces and intestinal fluids.
Claim 14
Dependent Claim
20 words
The medical device of any one of claims 1 to 13 further comprising an agent that displaces a crosslinking ion.
Claim 15
Dependent Claim
52 words
The medical device of claim 14 wherein said agent that displaces a crosslinking ion comprises one or more members selected from the group consisting of ethylene diamine tetra acetic acid, ethylene diamine tetraacetate, citrate, organic phosphates, inorganic phosphates, trisodium carboxymethyloxysuccinate, nitrilotriacetic acid, maleic acid, oxalate, polyacrylic acid, sodium, potassium, calcium and magnesium.
Claim 16
Dependent Claim
29 words
The medical device of claim 15 wherein said inorganic phosphate is selected from the group consisting of pentasodium tripolyphosphate, mono and dibasic potassium phosphate, sodium pyrophosphate and phosphoric acid.
Claim 17
Dependent Claim
21 words
The medical device according to any one of the preceding claims which is sterilizable at a temperature of at least 121°C.
Claim 18
Independent Claim
23 words
A method for dissolving an in viv o medical device comprising treating said in vivo medical device with at least one chemical trigger.
Claim 19
Dependent Claim
30 words
The method of claim 18 wherein said in vivo medical device comprises ionically crosslinked polymer and wherein said chemical trigger comprises at least one agent that displaces a crosslinking ion.
Claim 20
Dependent Claim
23 words
A medical device according to claims 1 or 2 comprised of ionically crosslinked polymer hydrogel having a water content of less than 90%.
Claim 21
Independent Claim
24 words
A method of modifying a medical device comprising ionically crosslinked polymer, said method comprising heating said medical device at a temperature above about 40°C.
Claim 22
Independent Claim
54 words
A method of making a tubular shaped article comprising introducing an ionically crosslinkable polymer through a die to form a tube, simultaneously pumping a solution comprising crosslinking ion through said formed tube, and extruding said formed tube from said die into a solution comprising crosslinking ion, optionally followed by heat treating said formed tube.
Claim 23
Dependent Claim
28 words
The use of an ionically crosslinked polymer in the manufacture of a medical device particularly effective as a stent, a catheter or cannula, a plug or a constrictor.
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