EP0271216A2
Expired / Lapsed
EP
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Synthetic vascular prosthesis and method for manufacturing same
Assignee: JMS Co Ltd
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Filing: 1987-11-10
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Granted: —
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Expires: 2007-11-10
Abstract
Abstract A synthetic vascular prosthesis comprises a hollow tubular base member (A) having a multitude of continuous pores and formed of an elastomer material, and a hydrogel layer (C) formed on the inner surface (B) of the base member. The hydrogel layer is partly embedded in the inner portion of the base member at the pores, thereby permitting anchoring adhesion between the hydrogel layer and the base member. A method for manufacturing the synthetic vascular prosthesis is also disclosed, in which the formation of pores in the base member is effected by two separate steps and the hydrogel layer is formed after formation of an inner porous portion of the base member.
Inventors
- 👤 Masao Okada
- 👤 Kazuhiko Sakai
- 👤 Haruo Kimura
- 👤 Yoshito Ikada
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:48
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/56; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/14; A61L27/16; A61L27/28; A61L27/34; A61L27/507; A61L27/52; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
69 words
A synthetic vascular prosthesis comprising: a hollow tubular base member having a multitude of continuous pores and formed of an elastomer material; and a hydrogel layer formed on the inner surface of said base member, the outer portion of said hydrogel layer being partially embedded in the inner portion of said base member at said pores to thereby achieve anchoring adhesion between said hydrogel layer and said base member.
Claim 2
Dependent Claim
69 words
A synthetic vascular prosthesis comprising: a hollow tubular base member having a multitude of continuous pores and formed of an elastomer material; and a hydrogel layer formed on the inner surface of said base member, the outer portion of said hydrogel layer being partially embedded in the inner portion of said base member at said pores to thereby achieve anchoring adhesion between said hydrogel layer and said base member.
Claim 3
Dependent Claim
28 words
A synthetic vascular prosthesis according to claim 1, wherein said hydrogel layer is formed of a material selected from a group of polyvinyl alcohol and ethylene-vinyl alcohol copolymers.
Claim 4
Dependent Claim
32 words
A synthetic vascular prosthesis according to claim 2, wherein said polyvinyl alcohol has a degree of polymerization of from 500 to 10,000 and a degree of saponification of not less than 80%.
Claim 5
Dependent Claim
28 words
A synthetic vascular prosthesis according to claim 1, wherein said base member is formed of a material selected from a group of polyurethanes, polyurethane ureas and silicone polymers.
Claim 6
Dependent Claim
18 words
A synthetic vascular prosthesis according to claim 4, wherein said polyurethanes and polyurethane ureas are of polyether type.
Claim 7
Dependent Claim
24 words
A synthetic vascular prosthesis according to claim 5, wherein said polyether type polyurethanes and polyurethane ureas comprise polyether-segmented polyurethanes and polyether-segmented polyurethane ureas, respectively.
Claim 8
Independent Claim
159 words
A method for manufacturing a synthetic vascular prosthesis comprising the steps of : dissolving an elastomer material in a solvent; adding an inorganic salt to the solution and adjusting the viscosity of the solution; subjecting the solution to extrusion into a hollow tube; cutting said tube to a predetermined length to form a tubular base member; removing the solvent from said base member and drying said base member; removing the inorganic salt in the inner portion of said base member by dissolution with an acid to form a porous inner portion of said base member; coating a hydrogel material inside of said base member so that said hydrogel material forms a hydrogel layer on said base member with partially infiltrating into the pores of said porous inner portion; and further removing the inorganic salt in the outer portion of said base member by dissolution with an acid, thereby forming a porous outer portion having a multitude of continuous pores.
Claim 9
Independent Claim
159 words
A method for manufacturing a synthetic vascular prosthesis comprising the steps of : dissolving an elastomer material in a solvent; adding an inorganic salt to the solution and adjusting the viscosity of the solution; subjecting the solution to extrusion into a hollow tube; cutting said tube to a predetermined length to form a tubular base member; removing the solvent from said base member and drying said base member; removing the inorganic salt in the inner portion of said base member by dissolution with an acid to form a porous inner portion of said base member; coating a hydrogel material inside of said base member so that said hydrogel material forms a hydrogel layer on said base member with partially infiltrating into the pores of said porous inner portion; and further removing the inorganic salt in the outer portion of said base member by dissolution with an acid, thereby forming a porous outer portion having a multitude of continuous pores.
Claim 10
Dependent Claim
22 words
A method according to claim 7, wherein said elastomer material is selected from a group of polyether-segmented polyurethanes and polyether-segmented polyurethane ureas.
Claim 11
Dependent Claim
18 words
A method according to claim 8, wherein said solvent is selected from a group of tetrahydrofuran and dimethylformamide.
Claim 12
Dependent Claim
25 words
A method according to claim 7, wherein said inorganic salt is selected from a group of particles of calcium carbonate, magnesium oxide and magnesium hydroxide.
Claim 13
Dependent Claim
29 words
A method as claimed in claim 7, wherein more than 500 parts by weight of said inorganic salt is added per 100 parts by weight of said elastomer material.
References Cited (Backward Citations)
No citation records indexed.
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