EP0275215A1
Expired / Lapsed
EP
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Contrast agents for the gastrointestinal tract
Assignee: Guerbet SA
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Filing: 1988-01-15
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Granted: —
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Expires: 2008-01-15
Abstract
Abstract A contrast agent for investigating the gastrointestinal tract by nuclear magnetic resonance (NMR) scanning. The contrast agent comprises a complex formed between a) an amino di- or poly-phosphonate in which the phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion, in substantially permanent association with an insoluble particulate carrier. Suitable carriers include, for example, pharmaceutically acceptable, substantially physiologically insoluble, particulate phosphate carriers.
Inventors
- 👤 Peter John Sadler
- 👤 Andrew Bruce Mcewen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 09:56
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/02; C07F15/025; A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; A61K49/1818; C07F11/00; C07F11/005; C07F13/00; C07F13/005; C07F5/00; C07F5/003; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3817
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
55 words
A contrast agent for investigating the gastrointestinal tract by NMR scanning which comprises a complex formed between a) an amino di- or poly-phosphonate in which the phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion, in substantially permanent association with an insoluble particulate carrier, provided that said carrier is other than hydroxyapatite.
Claim 2
Dependent Claim
55 words
A contrast agent for investigating the gastrointestinal tract by NMR scanning which comprises a complex formed between a) an amino di- or poly-phosphonate in which the phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion, in substantially permanent association with an insoluble particulate carrier, provided that said carrier is other than hydroxyapatite.
Claim 3
Dependent Claim
17 words
A contrast agent as claimed in claim 1, wherein the di- or poly-phosphonate contains the group -N(CH₂PO₃H₂)₂.
Claim 4
Dependent Claim
48 words
A contrast agent as claimed in claim 1 or claim 2, wherein the poly-phosphonate has the general formula NX₂CH₂PO₃H₂, where the two groups X are the same or different and each is -CH₂PO₃H₂ or -(CH₂) n N(CH₂PO₃H₂)₂, and n is up to 10, or a non-toxic salt thereof.
Claim 5
Dependent Claim
14 words
A contrast agent as claimed in claim 3, wherein the poly-phosphonate is ethylenediamine tetramethylenephosphonate.
Claim 6
Dependent Claim
17 words
A contrast agent as claimed in claim 1 or claim 2, wherein the poly-phosphonate is metaxylenediamine tetramethylene-phosphonate.
Claim 7
Dependent Claim
21 words
A contrast agent as claimed in any of claims 1 to 5, wherein the paramagnetic metal ion is Gd(III) or Fe(III).
Claim 8
Dependent Claim
27 words
A contrast agent as claimed in any of claims 1 to 6, wherein the insoluble particulate carrier is a pharmaceutically acceptable, substantially physiologically insoluble, particulate phosphate carrier.
Claim 9
Dependent Claim
22 words
A contrast agent as claimed in claim 7, wherein said carrier is of the M-P₂O₅-H₂O type, where M is a divalent cation.
Claim 10
Dependent Claim
12 words
A contrast agent as claimed in claim 8, wherein M is calcium.
Claim 11
Dependent Claim
27 words
A contrast agent as claimed in any of claims 1 to 6, wherein the insoluble particulate carrier is aluminium hydroxide, aluminium oxide, magnesium hydroxide or magnesium trisilicate.
Claim 12
Dependent Claim
34 words
A contrast agent as claimed in any of the preceding claims, wherein the complex is present in solution at a concentration of from 1 to 50 mM with respect to the paramagnetic metal ion.
Claim 13
Dependent Claim
20 words
A contrast agent comprising a paramagnetic metal ion insolubilised on the surface of an insoluble particulate material by chemical means.
Claim 14
Dependent Claim
20 words
A contrast agent comprising a paramagnetic metal ion insolubilised on the surface of an insoluble particulate material by chemical means.
References Cited (Backward Citations)
GB2137612A
Cited
EP0210043A2
Cited
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