Patent US1534825A successfully refreshed from Google Patents.
EP0210043A2
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Contrast agent for NMR scanning
Assignee: Guerbet SA
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Filing: 1986-07-16
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Granted: —
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Expires: 2006-07-16
Abstract
Abstract Complexes formed between a) an amino di- or poly-phosphonate in which phosphonate groups comprise separate carbon atoms and b) a paramagnetic metal ion such as Gd<sup>3+</sup>, have calcified tissue seeking properties which make them useful as contrast agents for investigating bone metabolism by NMR scanning. Two preferred poly-phosphonates are ethylenediamine tetramethylphosphonate and meta- xylene-diamine tetramethylphosphonate.
Inventors
- 👤 Peter John Sadler
- 👤 Charles Thomas Harding
- 👤 James Duncan Kelly
- 👤 Andrew Bruce Mcewen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 17:35
CPC Classifications
C; C07; C07F; C07F13/00; C07F13/005; A; A61; A61K; A61K49/00; A61K49/06; C07F11/00; C07F11/005; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/3804; C07F9/3808; C07F9/3817; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
40 words
Use, for the preparation of a contrast agent for investigating calcified tissue by NMR scanning, of a complex formed between a) an amino di- or poly-phosphonate in which phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion.
Claim 2
Dependent Claim
40 words
Use, for the preparation of a contrast agent for investigating calcified tissue by NMR scanning, of a complex formed between a) an amino di- or poly-phosphonate in which phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion.
Claim 3
Dependent Claim
23 words
Use as claimed in claim 1, wherein the di- or poly-phosphonate contains the group -N(CH 2 PO 3 H 2 ) 2 .
Claim 4
Dependent Claim
63 words
Use as claimed in claim 1 or claim 2, wherein the poly-phosphonate has the general formula NX2CH2P03H2, where the two groups X are the same or different and each is - CH 2 P0 3 H 2 or - (CH 2 ) n N(CH 2 PO 3 H 2 ) 2 , and n is up to 10, or a non-toxic salt thereof.
Claim 5
Dependent Claim
12 words
Use as claimed in claim 3, wherein the poly-phosphonate is ethylenediamine tetramethylphosphonate.
Claim 6
Dependent Claim
15 words
Use as claimed in claim 1 or claim 2, wherein the poly-phosphonate is meta-xylene-diamine tetramethylphosphonate.
Claim 7
Dependent Claim
20 words
Use as claimed in any one of claims 1 to 5, wherein the paramagnetic metal ion is Gd(III) or Fe(III).
Claim 8
Dependent Claim
30 words
Use as claimed in claim 6, wherein the complex is formed from a) ethylenediamine tetramethylphosphonate and b) Gd(III) in a molar ratio of a) to b) of at least 1.5.
Claim 9
Dependent Claim
25 words
Use as claimed in claim 7, wherein the complex is present in solution at a concentration of from 1 to 20mM with respect to Gd.
Claim 10
Dependent Claim
30 words
An adduct with hydroxy apatite of a complex formed between a) an amino di- or poly-phosphonate in which phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion.
Claim 11
Dependent Claim
30 words
An adduct with hydroxy apatite of a complex formed between a) an amino di- or poly-phosphonate in which phosphonate groups comprise different carbon atoms, and b) a paramagnetic metal ion.
Claim 12
Dependent Claim
81 words
A complex formed between a) a di- or poly-phosphonate having the formula YN(CH2P03H2)2 or Z[N(CH 2 PO 3 H 2 ) 2 ] 2 where each of Y and Z is an aliphatic or aromatic group containing 1 to 12 carbon atoms including at least one continuous chain of 3 or more carbon atoms, which group may also contain one or more hydroxyl, ether, carboxylate, sulphonate, amine or aminomethylphosphonate groups, or a non-toxic salt thereof, and b) a paramagnetic metal ion.
Claim 13
Dependent Claim
81 words
A complex formed between a) a di- or poly-phosphonate having the formula YN(CH2P03H2)2 or Z[N(CH 2 PO 3 H 2 ) 2 ] 2 where each of Y and Z is an aliphatic or aromatic group containing 1 to 12 carbon atoms including at least one continuous chain of 3 or more carbon atoms, which group may also contain one or more hydroxyl, ether, carboxylate, sulphonate, amine or aminomethylphosphonate groups, or a non-toxic salt thereof, and b) a paramagnetic metal ion.
Claim 14
Dependent Claim
15 words
A complex as claimed in claim 10, wherein the paramagnetic metal is Gd 3+ .
Claim 15
Dependent Claim
16 words
A complex formed from meta-xylene-diamine tetramethylphosphonic acid or a non-toxic salt thereof, and Gd 3 +.
Claim 16
Dependent Claim
16 words
A complex formed from meta-xylene-diamine tetramethylphosphonic acid or a non-toxic salt thereof, and Gd 3 +.
References Cited (Backward Citations)
No citation records indexed.
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