Patent USRE30239E successfully refreshed from Google Patents.
USRE30239E
Expired / Lapsed
US
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Cell proliferation and tissue invasion inhibitor
Assignee: Klaus E. Kuettner
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Filing: 1978-06-05
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Granted: 1980-03-25
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Expires: 1998-06-05
Abstract
Abstract A composition of matter having activity as an inhibitor of cell proliferation .Iadd.and tissue invasion.Iaddend.is obtained by aqueous extraction of tissue having a high content of collagen and/or proteoglycans.
Inventors
- 👤 Klaus E. Kuettner
- 👤 Reuben Eisenstein
- 👤 Nino Sorgente
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:27
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/32; A61K35/44
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
107 words
The method of preparing a composition of matter having activity as an inhibitor of cell proliferation .Iadd.and tissue invasion .Iaddend.comprising the steps of providing connective tissue having a high content of collagen or proteoglycans in condition for extraction, extracting said inhibitor from said tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted, separating the resultant aqueous extract from the tissue, recovering from the aqueous extract substances having a molecular weight below about 50,000, treating the fraction of aqueous extract having a molecular weight below about 50,000 to remove salts therefrom, and dehydrating the resultant material.
Claim 2
Independent Claim
107 words
The method of preparing a composition of matter having activity as an inhibitor of cell proliferation .Iadd.and tissue invasion .Iaddend.comprising the steps of providing connective tissue having a high content of collagen or proteoglycans in condition for extraction, extracting said inhibitor from said tissue with an aqueous extraction medium which includes a solute which does not irreversibly denature the proteinaceous matter to be extracted, separating the resultant aqueous extract from the tissue, recovering from the aqueous extract substances having a molecular weight below about 50,000, treating the fraction of aqueous extract having a molecular weight below about 50,000 to remove salts therefrom, and dehydrating the resultant material.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the connective tissue comprises tissue normally devoid of an intimate capillary blood supply.
Claim 4
Dependent Claim
10 words
The method of claim 2 wherein the tissue comprises cartilage.
Claim 5
Dependent Claim
11 words
The method of claim 2 wherein the tissue comprises blood vessels.
Claim 6
Dependent Claim
24 words
A composition of matter having activity as an inhibitor of cell proliferation .Iadd.and tissue invasion .Iaddend.comprising the product of the method of claim 1.
Claim 7
Dependent Claim
21 words
A composition of matter having activity as an inhibitor of cell proliferation comprising the product of the method of claim 2.
Claim 8
Dependent Claim
17 words
A method of inhibiting proliferation of cells comprising treating the cells with the product of claim 1.
Claim 9
Dependent Claim
17 words
A method of inhibiting proliferation of cells comprising treating the cells with the product of claim 2.
Claim 10
Dependent Claim
17 words
A method of inhibiting proliferation of cells comprising treating the cells with the product of claim 3.
Claim 11
Dependent Claim
17 words
A method of inhibiting proliferation of cells comprising treating the cells with the product of claim 4.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-25 | 1983-09-24 | 1984-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-25 | 1987-09-24 | 1988-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-25 | 1991-09-24 | 1992-03-25 | $7700.00 | Window Closed / Lapsed |