US7318840B2
Expired / Lapsed
US
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Intervertebral disc treatment devices and methods
Assignee: SDGI Holdings Inc
•
Filing: 2004-11-17
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Granted: 2008-01-15
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Expires: 2024-11-17
Abstract
Abstract Intervertebral disc treatment devices and methods are provided. An intervertebral disc treatment device includes a fibrous body sized for introduction into a disc cavity of a damaged disc wherein the body incorporates an effective amount of a tissue growth factor. Intervertebral disc treatment apparatuses are also described that include such a disc treatment device in combination with a delivery apparatus for retaining and selectively releasing the device into the disc cavity. Methods for treatment include providing a disc treatment device as described above and inserting the device into an opening in an annulus fibrous and into the disc cavity. The methods further include stimulating tissue growth within the disc cavity of the intervertebral disc.
Inventors
- 👤 William F. McKay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:55
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/44; A61F2/441; A61F2/46; A61F2/4603; A61F2/4611; A61P; A61P19/00; A61F2/3094; A61F2/30965; A61F2/442; A61F2/28; A61F2002/2817; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30075; A61F2002/30108; A61F2002/30199; A61F2002/30224; A61F2002/3023; A61F2002/4435; A61F2002/444; A61F2002/4495; A61F2002/4625; A61F2002/4627; A61F2210/00; A61F2210/0061; A61F2230/00; A61F2230/0063; A61F2230/0069; A61F2310/00; A61F2310/00005; A61F2310/00365; A61F2310/00377
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
75 words
A method of preventing effluence from a disc cavity of a damaged intervertebral disc having an annulus Fibrosus having an opening, said method comprising inserting a fibrous plug into the cavity of said disc defined by the annulus fibrosus so as to position said fibrous plug beyond the annulus fibrosus and completely within the cavity, with said fibrous plug abutting an inner surface of the annulus fibrosus so as to block effluence from said opening.
Claim 2
Independent Claim
75 words
A method of preventing effluence from a disc cavity of a damaged intervertebral disc having an annulus Fibrosus having an opening, said method comprising inserting a fibrous plug into the cavity of said disc defined by the annulus fibrosus so as to position said fibrous plug beyond the annulus fibrosus and completely within the cavity, with said fibrous plug abutting an inner surface of the annulus fibrosus so as to block effluence from said opening.
Claim 3
Dependent Claim
25 words
The method of claim 1 , wherein said fibrous plug is comprised of fibers coated with a solid carrier matrix comprising the tissue growth factor.
Claim 4
Dependent Claim
11 words
The method of claim 1 , wherein said plug is cylindrical.
Claim 5
Dependent Claim
13 words
The method of claim 1 , wherein said fibrous plug comprises synthetic fibers.
Claim 6
Dependent Claim
28 words
The method of claim 4 , wherein said synthetic fibers comprise a material selected from the group consisting of polyamides, polyesters, polyethylenes, polyacrylonitriles, polyurethanes, polypropylenes and mixtures thereof.
Claim 7
Dependent Claim
13 words
The method of claim 1 , wherein said fibrous plug comprises natural fibers.
Claim 8
Dependent Claim
12 words
The method of claim 6 , wherein said natural fibers comprise collagen.
Claim 9
Dependent Claim
12 words
The method of claim 6 , wherein said natural fibers comprise elastin.
Claim 10
Dependent Claim
22 words
The method of claim 1 , wherein said plug comprises an effective amount of a tissue growth composition to stimulate disc repair.
Claim 11
Dependent Claim
16 words
The method of claim 9 , wherein said tissue growth composition is incorporated within said body.
Claim 12
Dependent Claim
20 words
The method of claim 9 , wherein said tissue growth composition is bound to an exterior surface of said body.
Claim 13
Dependent Claim
16 words
The method of claim 11 , wherein said tissue growth composition comprises a biocompatible polymeric carrier.
Claim 14
Dependent Claim
14 words
The method of claim 12 , wherein said polymer is a naturally occurring polymer.
Claim 15
Dependent Claim
11 words
The method of claim 13 , wherein said polymer is collagen.
Claim 16
Dependent Claim
101 words
The method of claim 9 , wherein said tissue growth composition comprises tissue growth factor selected from the group consisting of Transforming Growth Factor-beta (TGF-B) and members of the TGF-B superfamily, Fibroblast Growth Factor (FGF) and members of the FGF family, Platelet Derived Growth Factor (PDGF) and members of the PDGF family, members of the hedgehog family of proteins, interleukins (IIs), Insulin-like Growth Factor (IGF) and members of the IGF family, colony-stimulating factor (CSF) and members of the CSF family, Growth Differentiation Factors (GDFs), Cartilage Derived Growth Factors (CDGFs), Cartilage Derived Morphogenic Proteins (CDMPs), Bone Morphogenetic Proteins (BMPs), and mixtures thereof.
Claim 17
Dependent Claim
16 words
The method of claim 15 , wherein said tissue growth factor is a recombinant human protein.
Claim 18
Dependent Claim
16 words
The method of claim 15 , wherein said tissue growth factor is a bone morphogenic protein.
Claim 19
Dependent Claim
41 words
The method of claim 17 , wherein said bone morphogenetic protein is selected from the group consisting of BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, BMP-16, BMP-17, BMP-18, and mixtures or heterodimers thereof.
Claim 20
Independent Claim
74 words
A method for treating a damaged intervertebral disc, comprising: (a) providing an opening in an annulus fibrosus of the damaged intervertebral disc; (b) passing a non-prosthetic delivery body through and beyond said opening and completely into a disc cavity defined by the annulus fibrosus, the delivery body incorporating a tissue growth factor; and (c) the delivery body releasing the tissue growth factor in the disc cavity and promoting tissue growth in the disc cavity.
Claim 21
Independent Claim
74 words
A method for treating a damaged intervertebral disc, comprising: (a) providing an opening in an annulus fibrosus of the damaged intervertebral disc; (b) passing a non-prosthetic delivery body through and beyond said opening and completely into a disc cavity defined by the annulus fibrosus, the delivery body incorporating a tissue growth factor; and (c) the delivery body releasing the tissue growth factor in the disc cavity and promoting tissue growth in the disc cavity.
Claim 22
Dependent Claim
14 words
The method of claim 19 , wherein said delivery body comprises a natural polymer.
Claim 23
Dependent Claim
12 words
The method of claim 19 , wherein said delivery body is cylindrical.
Claim 24
Dependent Claim
13 words
The method of claim 19 , wherein said delivery body comprises synthetic fibers.
Claim 25
Dependent Claim
28 words
The method of claim 22 , wherein said synthetic fibers comprise a material selected from the group consisting of polyamides, polyesters, polyethylenes, polyacrylonitriles, polyurethanes, polypropylenes and mixtures thereof.
Claim 26
Dependent Claim
13 words
The method of claim 19 , wherein said delivery body comprises natural fibers.
Claim 27
Dependent Claim
12 words
The method of claim 24 , wherein said natural fibers comprise collagen.
Claim 28
Dependent Claim
12 words
The method of claim 24 , wherein said natural fibers comprise elastin.
Claim 29
Dependent Claim
98 words
The method of claim 19 , wherein said tissue growth factor is selected from the group consisting of Transforming Growth Factor-beta (TGF-B) and members of the TGF-B superfamily, Fibroblast Growth Factor (FGF) and members of the FGF family, Platelet Derived Growth Factor (PDGF) and members of the PDGF family, members of the hedgehog family of proteins, interleukins (Us), Insulin-like Growth Factor (IGF) and members of the IGF family, colony-stimulating factor (CSF) and members of the CSF family, Growth Differentiation Factors (GDFs), Cartilage Derived Growth Factors (CDGFs), Cartilage Derived Morphogenic Proteins (CDMPs), Bone Morphogenetic Proteins (BMPs), and mixtures thereof.
Claim 30
Dependent Claim
16 words
The method of claim 27 , wherein said tissue growth factor is a recombinant human protein.
Claim 31
Dependent Claim
16 words
The method of claim 27 , wherein said tissue growth factor is a bone morphogenic protein.
Claim 32
Dependent Claim
41 words
The method of claim 29 , wherein said bone morphogenetic protein is selected from the group consisting of BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, BMP-16, BMP-17, BMP-18, and mixtures or heterodimers thereof.
Claim 33
Dependent Claim
22 words
The method of claim 19 , wherein said delivery body incorporates a composition comprising the tissue growth factor within a biocompatible carrier.
Claim 34
Dependent Claim
15 words
The method of claim 31 , wherein said composition is incorporated within said delivery body.
Claim 35
Dependent Claim
19 words
The method of claim 31 , wherein said composition is bound to an exterior surface of said delivery body.
Claim 36
Dependent Claim
13 words
The method of claim 31 , wherein said biocompatible carrier comprises a polymer.
Claim 37
Dependent Claim
14 words
The method of claim 34 , wherein said polymer is a naturally occurring polymer.
Claim 38
Dependent Claim
11 words
The method of claim 35 , wherein said polymer is collagen.
Claim 39
Independent Claim
88 words
A method for treating a damaged intervertebral disc in a vertebrate, the intervertebral disc having an annulus fibrosus having a rupture opening, the method comprising introducing at least a first amount of a tissue growth factor into a disc cavity of the ruptured intervertebral disc, and sealing the rupture opening of the annulus with a sealant device, wherein said first amount of tissue growth factor is separate from said sealant device during said introducing step, and wherein said introducing step is conducted before or after said sealing step.
Claim 40
Independent Claim
88 words
A method for treating a damaged intervertebral disc in a vertebrate, the intervertebral disc having an annulus fibrosus having a rupture opening, the method comprising introducing at least a first amount of a tissue growth factor into a disc cavity of the ruptured intervertebral disc, and sealing the rupture opening of the annulus with a sealant device, wherein said first amount of tissue growth factor is separate from said sealant device during said introducing step, and wherein said introducing step is conducted before or after said sealing step.
Claim 41
Dependent Claim
13 words
The method of claim 37 , wherein said sealant device comprises synthetic fibers.
Claim 42
Dependent Claim
14 words
The method of claim 37 , wherein said sealant device comprises a natural polymer.
Claim 43
Dependent Claim
19 words
The method of claim 37 , wherein said sealant device incorporates a second amount of a tissue growth factor.
Claim 44
Dependent Claim
28 words
The method of claim 37 , wherein said sealant device has a second amount of a tissue growth factor bound to an exterior surface of said sealant device.
Claim 45
Dependent Claim
13 words
The method of claim 37 , wherein said sealant device comprises natural fibers.
Claim 46
Dependent Claim
12 words
The method of claim 42 , wherein said natural fibers comprise collagen.
Claim 47
Dependent Claim
12 words
The method of claim 42 , wherein said natural fibers comprise elastin.
Claim 48
Dependent Claim
17 words
The method of claim 37 , wherein said tissue growth factor is incorporated within a biocompatible carrier.
Claim 49
Dependent Claim
15 words
The method of claim 45 , wherein said biocompatible carrier comprises a naturally occurring polymer.
Claim 50
Dependent Claim
11 words
The method of claim 46 , wherein said polymer is collagen.
Claim 51
Dependent Claim
98 words
The method of claim 37 , wherein said tissue growth factor is selected from the group consisting of Transforming Growth Factor-beta (TGF-B) and members of the TGF-B superfamily, Fibroblast Growth Factor (FGF) and members of the FGF family, Platelet Derived Growth Factor (PDGF) and members of the PDGF family, members of the hedgehog family of proteins, interleukins (IIs), Insulin-like Growth Factor (IGF) and members of the IGF family, colony-stimulating factor (CSF) and members of the CSF family, Growth Differentiation Factors (GDFs), Cartilage Derived Growth Factors (CDGFs), Cartilage Derived Morphogenic Proteins (CDMPs), Bone Morphogenetic Proteins (BMPs), and mixtures thereof.
Claim 52
Dependent Claim
16 words
The method of claim 48 , wherein said tissue growth factor is a bone morphogenic protein.
Claim 53
Dependent Claim
41 words
The method of claim 49 , wherein said bone morphogenetic protein is selected from the group consisting of BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-14, BMP-15, BMP-16, BMP-17, BMP-18, and mixtures or heterodimers thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2011-01-14 | 2011-07-16 | 2012-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2015-01-14 | 2015-07-16 | 2016-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2019-01-14 | 2019-07-16 | 2020-01-15 | $7700.00 | Window Closed / Lapsed |