Patent US4952213A successfully refreshed from Google Patents.
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System and method for enhancing cardiac signal sensing by cardiac pacemakers through genetic treatment
Assignee: Medtronic Inc
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Filing: 2001-07-02
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Granted: 2003-12-16
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Expires: 2021-07-02
Abstract
Abstract The present invention provides delivery systems for and methods of delivering ion channel protein genetic material to cardiac cells in areas adjacent to where an electrode is to be positioned in a patient's heart to improve or correct the signal to noise ratio of cardiac signals, such as the P-wave. More specifically, there is provided a system and method for delivering sodium ion channel proteins or nucleic acid molecules encoding sodium ion channel proteins to a site in the heart adjacent to an electrode to increase the expression of the same, thereby enhancing the cardiac signal amplitude and enabling improved sensing of cardiac signals by an implanted pacemaker.
Inventors
- 👤 Kenneth B. Stokes
- 👤 Josée Morissette
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:43
CPC Classifications
A; A61; A61N; A61N1/00; A61N1/18; A61N1/32; A61N1/36; A61N1/362; A61N1/37; A61N1/3702; A61M; A61M37/00; A61N1/02; A61N1/04; A61N1/05; A61N1/056; A61N1/0565; A61N1/0568; A61N1/057; A61N1/0573; A61N1/0575; A61B; A61B17/00; A61B17/34; A61B17/3468; A61K; A61K48/00; A61M25/00; A61M25/0043; A61M2025/0057; A61M25/0067; A61M25/0082; A61M25/0084; A61M2025/0089; A61N2001/058
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
159 words
An implantable system for pacing a patient's heart and for delivering a predetermined genetic material to cells adjacent to a pacing electrode positioned in said patient's heart, comprising: a supply of genetic material comprising cells containing DNA or RNA encoding an ion channel protein; a catheter, said catheter having proximal and distal ends, a lumen through at least a part thereof and connecting to said distal end, a pacing electrode positioned at said distal end for engaging said patient's heart wall, said electrode having a channel therethrough in communication with said lumen, and a conductor connecting said proximal end to said electrode, a pulse generator connected electrically to said conductor at said catheter proximal end for delivering pace pulses to said electrode, reservoir means for holding said supply of genetic material, and delivery means for delivering said genetic material from said reservoir to said lumen, whereby said material passes through said lumen and said channel to said heart wall.
Claim 2
Dependent Claim
159 words
An implantable system for pacing a patient's heart and for delivering a predetermined genetic material to cells adjacent to a pacing electrode positioned in said patient's heart, comprising: a supply of genetic material comprising cells containing DNA or RNA encoding an ion channel protein; a catheter, said catheter having proximal and distal ends, a lumen through at least a part thereof and connecting to said distal end, a pacing electrode positioned at said distal end for engaging said patient's heart wall, said electrode having a channel therethrough in communication with said lumen, and a conductor connecting said proximal end to said electrode, a pulse generator connected electrically to said conductor at said catheter proximal end for delivering pace pulses to said electrode, reservoir means for holding said supply of genetic material, and delivery means for delivering said genetic material from said reservoir to said lumen, whereby said material passes through said lumen and said channel to said heart wall.
Claim 3
Dependent Claim
16 words
The implantable system of claim 1 , wherein said reservoir is mounted in said pulse generator.
Claim 4
Dependent Claim
13 words
The implantable system of claim 1 , wherein said delivery means is passive.
Claim 5
Dependent Claim
14 words
The implantable system of claim 1 , wherein said delivery means comprises a pump.
Claim 6
Dependent Claim
29 words
The implantable system of claim 1 , wherein said electrode is substantially concentric with respect to the catheter axis, and the channel passes through the center of said electrode.
Claim 7
Dependent Claim
24 words
The system as described in claim 1 , further comprising: control means for controlling operation of said delivery means to deliver respective said doses.
Claim 8
Dependent Claim
29 words
The implantable delivery system of claim 1 , wherein said control means comprises initiating means for initiating delivery of said genetic material, said initiating means comprising an external programmer.
Claim 9
Dependent Claim
23 words
The implantable delivery system of claim 1 , wherein said control means comprises automatic means for automatically initiating delivery of said genetic material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-12-15 | 2007-06-16 | 2007-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-12-15 | 2011-06-16 | 2011-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-12-15 | 2015-06-16 | 2015-12-16 | $7700.00 | Window Closed / Lapsed |