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US6626173B2
Expired / Lapsed
US
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Dry powder inhaler
Assignee: Kos Life Sciences Inc
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Filing: 2001-01-08
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Granted: 2003-09-30
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Expires: 2021-01-08
Abstract
Abstract A dry powder inhaler having a housing, at least one single dose storage chamber able to contain a single unit dose, a discharge path adjacent the storage chamber, and a flexible and bendable seal plate closing the discharge path. When an air flow under pressure is applied to the top of the dose, the top seal is broken and the dose is driven against the seal plate which deflects away, allowing the powder of the dose to be driven into and along the discharge path. The air flow causes the seal plate (in the discharge path) to vibrate, which acts to break up the dose into particles of preferred size, as the dose is carried along with the air flow and delivered to a patient.
Inventors
- 👤 Perry Genova
- 👤 Warren Jewett
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:09
CPC Classifications
B; B05; B05B; B05B17/00; B05B17/04; B05B17/06; B05B17/0692; A; A61; A61M; A61M11/00; A61M11/001; A61M11/005; A61M11/02; A61M15/00; A61M15/0001; A61M15/0005; A61M15/0028; A61M15/0045; A61M15/0046; A61M15/0048; A61M2202/00; A61M2202/06; A61M2202/064
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
230 words
A dry powder inhaler operable with a source of pressurized air, comprising: a—a base substrate having top and front surfaces with an exit channel in the form of a trough defined in said top surface and extending lengthwise to and intersecting said front surface; b—a sheet of flexible material overlying said top surface of said base substrate; c—a dose storage substrate overlying said sheet, said dose storage substrate containing at least one single unit dose of agglomerated medicament powder, said dose storage substrate having a bottom surface adjacent said sheet, at least one chamber defined therein to contain said unit dose, and an opposite top surface, d—an air inlet substrate overlying said dose storage substrate and including at least one passageway for directing pressurized air from a source onto said top surface of said dose storage substrate, said pressurized air forcing said dose from said chamber, said sheet being deformed by said pressurized air downward into said trough, thus providing a discharge passage along said top surface of said sheet, and said dose being driven downward by application of said pressurized air, and forced against said sheet, said sheet vibrating so as to deagglomerate and fluidize said dose and meter the flow of powder through said trough, said dose being carried in a fluidized form through said trough, and said dose exiting from said front surface of said base substrate.
Claim 2
Dependent Claim
230 words
A dry powder inhaler operable with a source of pressurized air, comprising: a—a base substrate having top and front surfaces with an exit channel in the form of a trough defined in said top surface and extending lengthwise to and intersecting said front surface; b—a sheet of flexible material overlying said top surface of said base substrate; c—a dose storage substrate overlying said sheet, said dose storage substrate containing at least one single unit dose of agglomerated medicament powder, said dose storage substrate having a bottom surface adjacent said sheet, at least one chamber defined therein to contain said unit dose, and an opposite top surface, d—an air inlet substrate overlying said dose storage substrate and including at least one passageway for directing pressurized air from a source onto said top surface of said dose storage substrate, said pressurized air forcing said dose from said chamber, said sheet being deformed by said pressurized air downward into said trough, thus providing a discharge passage along said top surface of said sheet, and said dose being driven downward by application of said pressurized air, and forced against said sheet, said sheet vibrating so as to deagglomerate and fluidize said dose and meter the flow of powder through said trough, said dose being carried in a fluidized form through said trough, and said dose exiting from said front surface of said base substrate.
Claim 3
Dependent Claim
21 words
An inhaler according to claim 1 wherein said pressurized air is applied at a pressure in the range of 1-100 psi.
Claim 4
Dependent Claim
25 words
An inhaler according to claim 2 wherein said pressurized air is applied to said dose for a duration in the range of 10-milliseconds to 1000-milliseconds.
Claim 5
Dependent Claim
25 words
An inhaler according to claim 1 wherein said pressurized air is applied to said dose for a duration in the range of 10-milliseconds to 1000-milliseconds.
Claim 6
Dependent Claim
22 words
An inhaler according to claim 1 wherein a standing wave in said vibrating sheet operates in a frequency range of 10-60 kHz.
Claim 7
Dependent Claim
23 words
An inhaler according to claim 1 wherein said sheet comprises a Mylar film having thickness in the range of 0.0005 to 0.020 inches.
Claim 8
Dependent Claim
27 words
An inhaler according to claim 1 which produces a discharge in the form of a plume of dry powder particles sized in the range of 2-8 microns.
Claim 9
Dependent Claim
26 words
An inhaler according to claim 1 wherein said unit dose is protected by a protective seal, which is broken upon activation of said pressurized air source.
Claim 10
Dependent Claim
31 words
An inhaler according to claim 1 wherein said trough has inlet and exit ends, and said trough is sloped so that it becomes deeper in the direction of its exit end.
Claim 11
Dependent Claim
14 words
An inhaler according to claim 9 wherein said trough has generally parallel side walls.
Claim 12
Dependent Claim
130 words
An inhaler according to claim 1 wherein: a said base substrate has a plurality of said troughs spaced apart from each other, b said sheet overlies all of said troughs, c said dose storage substrate contains a plurality of single unit doses, each of said unit doses being situated within chambers defined in said dose storage substrate, each of said chambers being situated so as to align with and overlie one of said troughs, and d said air inlet substrate having at least one passageway laterally movable to overlie and be directed selectively to each of said stored single unit doses, said pressurized air being applicable via said air inlet substrate selectively to each of said doses to be directed as a plume of powder from its respective exit channel.
Claim 13
Dependent Claim
98 words
An inhaler according to claim 1 wherein: a said base has a single exit channel, b said sheet overlies said trough, c said air inlet substrate has at least one passageway, said passageway being fixed in a position over said trough, d said dose storage substrate contains a plurality of single unit doses, said dose storage substrate capable of being rotatably positioned and aligned over said trough and beneath said air inlet passageway, said pressurized air being applicable via said passageway selectively to each of said doses to be directed as a plume of powder from said trough.
Claim 14
Independent Claim
109 words
A method of deagglomerizing a dose of agglomerated dry powder in an inhaler where pressurized air is applied to said dose, blowing it through an exit channel having inlet and exit ends, comprising the steps: a providing a sheet of vibratable material in said exit channel, extending generally from said inlet to said exit end, b directing said pressurized air carrying said dry powder to flow along the surface of said sheet in said exit channel thereby causing said sheet to stretch deform and vibrate and create a standing wave in said sheet, whereby said standing wave helps to deagglomerize and fluidize said powder in said pressurized air flow.
Claim 15
Independent Claim
109 words
A method of deagglomerizing a dose of agglomerated dry powder in an inhaler where pressurized air is applied to said dose, blowing it through an exit channel having inlet and exit ends, comprising the steps: a providing a sheet of vibratable material in said exit channel, extending generally from said inlet to said exit end, b directing said pressurized air carrying said dry powder to flow along the surface of said sheet in said exit channel thereby causing said sheet to stretch deform and vibrate and create a standing wave in said sheet, whereby said standing wave helps to deagglomerize and fluidize said powder in said pressurized air flow.
Claim 16
Dependent Claim
21 words
A method according to claim 13 wherein said pressurized air is applied at a pressure in the range of 1-100 psi.
Claim 17
Dependent Claim
22 words
A method according to claim 13 wherein said pressurized air is applied for a duration in the range of 10-milliseconds to 1000-milliseconds.
Claim 18
Dependent Claim
18 words
A method according to claim 13 wherein said vibrating sheet operates in a frequency range of 10-60 kHz.
Claim 19
Dependent Claim
20 words
A method according to claim 13 wherein said deagglomerated dry powder has particles sized in the range of 2-8 microns.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2006-09-29 | 2007-03-31 | 2007-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-09-29 | 2011-03-31 | 2011-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-09-29 | 2015-03-31 | 2015-09-30 | $7700.00 | Window Closed / Lapsed |