US6602276B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
Assignee: Zoll Circulation Inc
•
Filing: 2001-03-01
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Granted: 2003-08-05
•
Expires: 2021-03-01
Abstract
Abstract The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
Inventors
- 👤 John D. Dobak, III
- 👤 Hans W. Kramer
- 👤 Steve A. Yon
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:47
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/02; A61F; A61F7/00; A61F7/12; A61F7/123; A61B18/04; A61B18/08; A61B17/00; A61B17/22; A61B2017/22001; A61B2017/22002; A61B2017/22051; A61B2017/22054; A61B2018/00005; A61B2018/00011; A61B2018/00023; A61B2018/00041; A61B2018/00053; A61B2018/00214; A61B2018/0022; A61B2018/0212; A61B2018/0231; A61B2018/0262; A61F2007/0054; A61F2007/0056; A61F7/02; A61F2007/0295; A61F2007/0298; A61F2007/126
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
91 words
A method of reducing atrial fibrillation, comprising: inserting a catheter at least partially into the heart, the catheter having a balloon, a portion of the balloon located in the left atrium and a portion of the balloon located in a pulmonary vein; inflating the balloon with a perfluorocarbon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium, the perfluorocarbon having a temperature in the range of about −10° C. to −50° C.
Claim 2
Independent Claim
91 words
A method of reducing atrial fibrillation, comprising: inserting a catheter at least partially into the heart, the catheter having a balloon, a portion of the balloon located in the left atrium and a portion of the balloon located in a pulmonary vein; inflating the balloon with a perfluorocarbon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium, the perfluorocarbon having a temperature in the range of about −10° C. to −50° C.
Claim 3
Dependent Claim
24 words
The method of claim 1 , wherein the balloon has a working region having a length of between about 5 mm and 10 mm.
Claim 4
Dependent Claim
90 words
The method of claim 1 , further comprising: inserting a wire capable of rupturing the atrial septum from the femoral vein into the right atrium; forming a hole using the wire in the interatrial septum between the right atrium and the left atrium; inserting a guide catheter into the right atrium; inserting a guide wire through the guide catheter into the right atrium and further into a pulmonary vein; disposing the catheter over the guidewire into a volume defined by the joint of the right atrium and the pulmonary vein.
Claim 5
Dependent Claim
78 words
A catheter system for vessel ablation, comprising: a catheter shaft; a warm balloon disposed on the catheter shaft, said warm balloon fluidically coupled to at least one lumen for inflating and deflating the warm balloon; and a cold balloon disposed on the catheter shaft, said cold balloon fluidically coupled to two lumens for circulating a cold working fluid to and from the cold balloon, such that said cold balloon is located adjacent but proximal to said warm balloon.
Claim 6
Dependent Claim
78 words
A catheter system for vessel ablation, comprising: a catheter shaft; a warm balloon disposed on the catheter shaft, said warm balloon fluidically coupled to at least one lumen for inflating and deflating the warm balloon; and a cold balloon disposed on the catheter shaft, said cold balloon fluidically coupled to two lumens for circulating a cold working fluid to and from the cold balloon, such that said cold balloon is located adjacent but proximal to said warm balloon.
Claim 7
Dependent Claim
15 words
The system of claim 4 , wherein said warm balloon is made of silicone tubing.
Claim 8
Dependent Claim
16 words
The system of claim 5 , wherein said warm balloon is secured by heat shrink tubing.
Claim 9
Dependent Claim
15 words
The system of claim 5 , wherein said warm balloon is secured by an adhesive.
Claim 10
Dependent Claim
14 words
The system of claim 5 , wherein said warm balloon is secured by bands.
Claim 11
Dependent Claim
11 words
The system of claim 8 , wherein said bands are metal.
Claim 12
Dependent Claim
13 words
The system of claim 4 , wherein said working fluid is a perfluorocarbon.
Claim 13
Dependent Claim
13 words
The system of claim 10 , wherein said working fluid is Galden fluid.
Claim 14
Dependent Claim
20 words
The system of claim 4 , wherein said warm balloon is structured and configured to anchor in a pulmonary vein.
Claim 15
Dependent Claim
28 words
The system of claim 12 , wherein said cold balloon is structured and configured to be disposed partially in a pulmonary vein and partially in the left atrium.
Claim 16
Dependent Claim
30 words
The system of claim 13 , wherein said cold balloon has a length of between about 1 to 2½ cm and a diameter of between about 1 to 2½ cm.
Claim 17
Dependent Claim
26 words
The system of claim 4 , further comprising at least one marker band disposed within one or both of the cold balloon and the warm balloon.
Claim 18
Dependent Claim
19 words
The system of claim 4 , further comprising a set of mapping electrodes disposed distal of the warm balloon.
Claim 19
Dependent Claim
16 words
The system of claim 4 , further comprising an insulation sleeve disposed around the catheter shaft.
Claim 20
Dependent Claim
16 words
The system of claim 17 , wherein the insulation sleeve is formed of a foamed extrusion.
Claim 21
Dependent Claim
36 words
The system of claim 4 , further comprising a silicone sleeve disposed circumferentially about the catheter shaft adjacent a point at which at least one of the cold or warm balloons attaches to the catheter shaft.
Claim 22
Dependent Claim
20 words
The system of claim 4 , wherein the cold balloon is doped with a biocompatible agent to promote heat transfer.
Claim 23
Independent Claim
118 words
A method of reducing atrial fibrillation, comprising: inserting a catheter at least partially into the heart, the catheter having a warm balloon and a cold balloon proximal of the warm balloon, at least a portion of the cold balloon located in the left atrium and at least a portion of the warm balloon located in a pulmonary vein; inflating the warm balloon with a biocompatible fluid; and inflating the cold balloon with a perfluorocarbon such that an exterior surface of the cold balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium, the perfluorocarbon having a temperature in the range of about −10° C. to −70° C.
Claim 24
Independent Claim
118 words
A method of reducing atrial fibrillation, comprising: inserting a catheter at least partially into the heart, the catheter having a warm balloon and a cold balloon proximal of the warm balloon, at least a portion of the cold balloon located in the left atrium and at least a portion of the warm balloon located in a pulmonary vein; inflating the warm balloon with a biocompatible fluid; and inflating the cold balloon with a perfluorocarbon such that an exterior surface of the cold balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium, the perfluorocarbon having a temperature in the range of about −10° C. to −70° C.
Claim 25
Dependent Claim
26 words
The method of claim 21 , wherein inflating the warm balloon includes pressurizing the warm balloon to a pressure of between about 1 to 2 atmospheres.
Claim 26
Dependent Claim
26 words
The method of claim 21 , wherein inflating the cold balloon includes pressurizing the cold balloon to a pressure of between about 5 to 7 atmospheres.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-08-04 | 2007-02-03 | 2007-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-08-04 | 2011-02-03 | 2011-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-08-04 | 2015-02-03 | 2015-08-05 | $7700.00 | Window Closed / Lapsed |