US6165216A
Expired / Lapsed
US
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Human cardiac valve placement with marine mammal ventricular outflow (aortic or pulmonary) valve
Assignee: Individual
•
Filing: 1996-07-12
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Granted: 2000-12-26
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Expires: 2016-07-12
Abstract
Abstract The present invention provides a method of treating human cardiac valve dysfunction, by replacing the existing valve with a novel bioprosthesis of the present invention which comprises a marine mammal ventricular outflow (aortic or pulmonary) valve. The marine mammal ventricular outflow valve is treated by a fixative agent to sterilize, fix, increase the strength of the leaflets and lessen the antigenicity of the tissue valve. Following this step, the marine mammal ventricular outflow valve can either be stent-mounted or can be unstented. The stent-mounted marine mammal ventricular outflow valve can be used to replace a human aortic, mitral, or tricuspid valve, while the unstented marine mammal ventricular outflow valve can be used to replace a human aortic or pulmonary valve. Being a natural trileaflet valve, with symmetrical cusps and no muscle shelf within the leaflet, the marine mammal ventricular outflow valve presents superior hemodynamic advantages over the existing aortic porcine and bovine pericardial valves. The increase thickness of the leaflets result in a long-term durability, without the attendant disadvantages of re-replacing a bioprosthesis. Alternatively, a marine mammal trileaflet valve can be contructed from tissues such as pericardium and fascia lata.
Inventors
- 👤 Efstathios Andreas Agathos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:38
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/507; A61F; A61F2/00; A61F2/02; A61F2/24; A61F2/2412; A61L27/36; A61L27/3604; A61L27/3641; A61L27/3645
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
24 words
A method of treating a human patient, comprising: i. providing a marine mammal trileaflet valve, and ii. surgically implanting said valve in said patient.
Claim 2
Independent Claim
24 words
A method of treating a human patient, comprising: i. providing a marine mammal trileaflet valve, and ii. surgically implanting said valve in said patient.
Claim 3
Dependent Claim
19 words
The method of claim 1, wherein said patient's existing aortic valve is replaced with said marine mammal trileaflet valve.
Claim 4
Dependent Claim
19 words
The method of claim 1, wherein said patient's existing pulmonary valve is replaced with said marine mammal trileaflet valve.
Claim 5
Dependent Claim
18 words
The method of claim 1, wherein said marine mammal valve is a fixed and sterilized stent-mounted trileaflet valve.
Claim 6
Dependent Claim
20 words
The method of claim 1, wherein said marine mammal valve is a fixed and sterilized whole excised unstented trileaflet valve.
Claim 7
Dependent Claim
16 words
The method of claim 1 wherein said marine mammal trileaflet valve is a ventricular outflow valve.
Claim 8
Dependent Claim
29 words
The method of claim 1, wherein said marine mammal trileaflet valve is a bioprothesis constructed from marine mammal tissues selected from the group consisting of pericardium or fascia lata.
Claim 9
Dependent Claim
16 words
The method of claim 1, wherein said marine mammal valve comprises a section of ascending aorta.
Claim 10
Dependent Claim
16 words
The method of claim 1, wherein said marine mammal valve comprises a section of pulmonary artery.
Claim 11
Dependent Claim
35 words
The method of claim 1, wherein said marine mammal valve has an inlet side and further comprises a flexible sewing skirt extending from said inlet side to facilitate suturing of the valve in said patient.
Claim 12
Independent Claim
39 words
A method of treating valve dysfunction in a human patient, comprising: i. providing a marine mammal ventricular outflow valve, and ii. replacing an existing dysfunctional aortic, mitral, tricuspid or pulmonary valve in said patient with said ventricular outflow valve.
Claim 13
Independent Claim
39 words
A method of treating valve dysfunction in a human patient, comprising: i. providing a marine mammal ventricular outflow valve, and ii. replacing an existing dysfunctional aortic, mitral, tricuspid or pulmonary valve in said patient with said ventricular outflow valve.
Claim 14
Dependent Claim
17 words
The method of claim 11, wherein said marine mammal valve is a fixed and sterilized stent-mounted valve.
Claim 15
Dependent Claim
17 words
The method of claim 11, wherein said marine mammal valve is a fixed and sterilized unstented valve.
Claim 16
Dependent Claim
28 words
The method of claim 11, wherein said marine mammal valve comprises a bioprothesis constructed from marine mammal tissues selected from the group consisting of pericardium or fascia lata.
Claim 17
Dependent Claim
16 words
The method of claim 11, wherein said marine mammal valve comprises a section of ascending aorta.
Claim 18
Dependent Claim
16 words
The method of claim 11, wherein said marine mammal valve comprises a section of pulmonary artery.
Claim 19
Dependent Claim
35 words
The method of claim 11, wherein said marine mammal valve has an inlet side and further comprises a flexible sewing skirt extending from said inlet side to facilitate suturing of the valve in said patient.
Claim 20
Dependent Claim
15 words
A composition, consisting of a fixed, marine mammal ventricular outflow valve having a sewing skirt.
Claim 21
Dependent Claim
15 words
A composition, consisting of a fixed, marine mammal ventricular outflow valve having a sewing skirt.
Claim 22
Dependent Claim
15 words
The composition of claim 18, wherein said valve is a sterilized whole excised unstented valve.
Claim 23
Dependent Claim
23 words
The composition of claim 18, wherein said marine mammal is selected from the group consisting of seals, sea lions, dolphins, porpoises, and whales.
Claim 24
Dependent Claim
36 words
An excised, marine mammal valve having an inlet side and further comprising a flexible sewing skirt extending from said inlet side, said flexible skirt configured so as to facilitate suturing of the valve in a patient.
Claim 25
Dependent Claim
36 words
An excised, marine mammal valve having an inlet side and further comprising a flexible sewing skirt extending from said inlet side, said flexible skirt configured so as to facilitate suturing of the valve in a patient.
Claim 26
Dependent Claim
15 words
The excised, marine mammal valve of claim 21, further comprising a section of ascending aorta.
Claim 27
Dependent Claim
15 words
The excised, marine mammal valve of claim 21, further comprising a section of pulmonary artery.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-26 | 2004-06-26 | 2004-12-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-26 | 2008-06-26 | 2008-12-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-26 | 2012-06-26 | 2012-12-26 | $7700.00 | Window Closed / Lapsed |