Patent US6156350A successfully refreshed from Google Patents.
US6156350A
Expired / Lapsed
US
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Methods and kits for use in preventing restenosis
Assignee: Cordis US Corp
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Filing: 1999-12-02
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Granted: 2000-12-05
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Expires: 2019-12-02
Abstract
Abstract Methods and kits are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.
Inventors
- 👤 Brent R. Constantz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:09
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/14; A61K33/20; A61P; A61P9/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
30 words
In a method of treating a vascular disease condition, the improvement comprising: contacting a vascular site of a host suffering from said condition with a solution having a subphysiologic pH.
Claim 2
Dependent Claim
30 words
In a method of treating a vascular disease condition, the improvement comprising: contacting a vascular site of a host suffering from said condition with a solution having a subphysiologic pH.
Claim 3
Dependent Claim
12 words
The method according to claim 1, wherein said contacting is by flushing.
Claim 4
Dependent Claim
14 words
The method according to claim 1, wherein said solution is an inorganic acid solution.
Claim 5
Dependent Claim
16 words
The method according to claim 3, wherein said inorganic acid solution is a hydrochloric acid solution.
Claim 6
Dependent Claim
12 words
The method according to claim 1, wherein said disease condition is restenosis.
Claim 7
Independent Claim
34 words
A method for at least slowing the progression of restenosis at a vascular site of a host, said method comprising: contacting said vascular site of a host with a solution having a subphysiologic pH.
Claim 8
Independent Claim
34 words
A method for at least slowing the progression of restenosis at a vascular site of a host, said method comprising: contacting said vascular site of a host with a solution having a subphysiologic pH.
Claim 9
Dependent Claim
16 words
The method according to claim 6, wherein said vascular site is statically contacted with said solution.
Claim 10
Dependent Claim
15 words
The method according to claim 6, wherein said vascular site is flushed with said solution.
Claim 11
Dependent Claim
14 words
The method according to claim 6, wherein said solution is an inorganic acid solution.
Claim 12
Dependent Claim
16 words
The method according to claim 9, wherein said inorganic acid solution is a hydrochloric acid solution.
Claim 13
Independent Claim
37 words
A method for at least slowing the progression of restenosis at a vascular site of a patient, said method comprising: contacting said vascular site with a hydrochloric acid solution having a pH of less than about 4.
Claim 14
Independent Claim
37 words
A method for at least slowing the progression of restenosis at a vascular site of a patient, said method comprising: contacting said vascular site with a hydrochloric acid solution having a pH of less than about 4.
Claim 15
Dependent Claim
18 words
The method according to claim 11, wherein said vascular site is statically contacted with said hydrochloric acid solution.
Claim 16
Dependent Claim
17 words
The method according to claim 11, wherein said vascular site is flushed with said hydrochloric acid solution.
Claim 17
Dependent Claim
20 words
The method according to claim 11, wherein said hydrochloric acid solution has a pH that does not exceed about 2.
Claim 18
Dependent Claim
15 words
The method according to claim 11, wherein said hydrochloric acid solution further includes a salt.
Claim 19
Dependent Claim
11 words
The method according to claim 15, wherein said salt is NaCl.
References Cited (Backward Citations)
US5902610A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-12-05 | 2004-06-05 | 2004-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-12-05 | 2008-06-05 | 2008-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-12-05 | 2012-06-05 | 2012-12-05 | $7700.00 | Window Closed / Lapsed |