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US6103233A
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Cellular and serum protein anchors and conjugates
Assignee: Conjuchem LLC
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Filing: 1995-06-07
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Granted: 2000-08-15
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Expires: 2015-06-07
Abstract
Abstract First and second compounds are provided, where the first compound is administered to a mammalian host into blood for covalent bonding to blood components, where the components have an extended lifetime in the blood stream. The first compound comprises an active functionality and an agent of interest or a first binding entity. A second compound may be subsequently administered to the patient, which comprises a second binding entity, complementary to the first binding entity and an agent of interest. By virtue of binding to long-lived blood components, the half-life of the agent of interest is greatly extended in vivo.
Inventors
- 👤 Philippe Pouletty
- 👤 Christine Pouletty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:27
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K39/00; A61K39/385; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6835; A61K47/6839; A61K47/6849; A61K47/6891; A61K47/6897; A61K47/6898; A61K47/69; A61K47/6901; A61P; A61P43/00; C; C07; C07K; C07K14/00; C07K14/005; C07K14/435; C07K14/705; C07K14/70503; C07K14/70514; C07K16/00; C07K16/08; C07K16/16; C07K16/18; C07K16/34; C07K16/44; A61K2039/505; A61K2039/60; A61K2039/6031; A61K2039/6056; A61K2039/62; A61K2039/625; A61K38/00; C12; C12N; C12N2740/00; C12N2740/00011; C12N2740/10011; C12N2740/16011; C12N2740/16111; C12N2740/16122
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
100 words
An isolated blood composition comprising: conjugates of immunoglobulins and serum albumin covalently bonded to a synthetic organic compound as a biologically active compound as the major protein conjugates in said blood composition, said conjugates resulting from the addition of said synthetic organic compound to blood, said synthetic organic compound comprising (a) a reactive functional group which reacts with proteins to form stable covalent bonds, and either (b) a biologically active compound of interest, or (c) a first binding member which is a member of a specific binding pair consisting of said first binding member and a complementary second binding member.
Claim 2
Dependent Claim
100 words
An isolated blood composition comprising: conjugates of immunoglobulins and serum albumin covalently bonded to a synthetic organic compound as a biologically active compound as the major protein conjugates in said blood composition, said conjugates resulting from the addition of said synthetic organic compound to blood, said synthetic organic compound comprising (a) a reactive functional group which reacts with proteins to form stable covalent bonds, and either (b) a biologically active compound of interest, or (c) a first binding member which is a member of a specific binding pair consisting of said first binding member and a complementary second binding member.
Claim 3
Dependent Claim
19 words
A blood composition according to claim 1, wherein said first binding member of a specific binding pair is biotin.
Claim 4
Dependent Claim
17 words
A blood composition according to claim 2, wherein said complementary second binding member is avidin or streptavidin.
Claim 5
Dependent Claim
20 words
A blood composition according to claim 1, wherein said addition of said synthetic organic compound to blood occurs ex vivo.
Claim 6
Dependent Claim
18 words
A blood composition according to claim 1 wherein said addition of said synthetic organic compound occurs in vivo.
Claim 7
Dependent Claim
20 words
The composition of claim 1 wherein said reactive functional group is selected from the group consisting of N-hydroxysuccinimide and N-hydroxysulfosuccinimide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-08-15 | 2004-02-14 | 2004-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-08-15 | 2008-02-14 | 2008-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-08-15 | 2012-02-14 | 2012-08-15 | $7700.00 | Window Closed / Lapsed |