US6071982A
Expired / Lapsed
US
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Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
Assignee: Cambridge Scientific Inc
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Filing: 1997-04-18
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Granted: 2000-06-06
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Expires: 2017-04-18
Abstract
Abstract A bioerodible polymeric semi-IPN alloy which comprises a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation; a second bioerodible polymer, which provides a biopolymeric scaffolding or internal reinforcement; and optionally a buffering compound that buffers the acidic products within a desired pH range. In a preferred embodiment, the second bioerodible polymer comprises polypropylene fumarate (PPF), which is cross-linked, desirably by a vinyl monomer such as vinyl pyrrolidone (VP) to form the biopolymeric scaffolding which provides the semi-IPN with dimensional and geometric stability.
Inventors
- 👤 Donald L. Wise
- 👤 Joseph D. Gresser
- 👤 Debra J. Trantolo
- 👤 Yung-Yueh Hsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:29
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61B; A61B17/00; A61B17/56; A61B17/58; A61B17/68; A61B17/84; A61B17/86; A61B17/866; A61L27/14; A61L27/26; A61L27/40; A61L27/44; A61L27/48; A61B17/80; A61B17/88; A61B17/8802; A61B17/8833; A61B2017/00004; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2817; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/3006; A61F2002/30062; A61F2002/30667; A61F2002/30677; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0014; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S525/00; Y10S525/903
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
109 words
A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, crosslinking initiator, and a therapeutically effective amount of a biologically active or therapeutic agent, wherein said biologically active or therapeutic agent is in a protective coating of said first bioerodible polymer; and b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer.
Claim 2
Dependent Claim
109 words
A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, crosslinking initiator, and a therapeutically effective amount of a biologically active or therapeutic agent, wherein said biologically active or therapeutic agent is in a protective coating of said first bioerodible polymer; and b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer.
Claim 3
Dependent Claim
33 words
The bone cement system of claim 1 further comprising in one of said parts a buffering compound in sufficiently high concentration so as to buffer said acidic products within a desired pH range.
Claim 4
Dependent Claim
16 words
The bone cement system of claim 1 wherein said second bioerodible polymer comprises polypropylene fumarate (PPF).
Claim 5
Dependent Claim
15 words
The bone cement system of claim 3 wherein said crosslinking agent is a vinyl monomer.
Claim 6
Dependent Claim
14 words
The bone cement system of claim 4 herein said crosslinking agent is vinyl pyrrolidone.
Claim 7
Dependent Claim
15 words
The bone cement system of claim 3 wherein said crosslinking agent is methyl methacrylate (MMA).
Claim 8
Dependent Claim
29 words
The bone cement system of claim 1 wherein said biologically active or therapeutic agent is selected from the group consisting of bone repair proteins, antibiotics, cells, and mixtures thereof.
Claim 9
Dependent Claim
19 words
The bone cement system of claim 1 wherein said first bioerodible polymer is different from said second bioerodible polymer.
Claim 10
Dependent Claim
41 words
The bone cement system of claim 1 wherein said first bioerodible polymer is selected from the group consisting of poly(lactide-co-glycolide) (PLGA); polydioxanone; poly(ε-caprolactone); polyanhydrides; poly(ortho esters); copoly(ether-esters); polyamides; polylactones; polypropylene fumarates (H(--O--CH(CH 3 )--CH 2 --O--CO--CH═CH--CO--) n OH); and combinations thereof.
Claim 11
Dependent Claim
39 words
The bone cement system of claim 2 wherein said buffering compound that buffers said acidic products within a desired pH range is selected from the group consisting of inorganic acid salts; organic acid salts; and polymeric organic acid salts.
Claim 12
Dependent Claim
38 words
The bone cement system of claim 2 wherein said buffering compound is selected from the group consisting of calcium carbonate, calcium phosphate, calcium acetate, calcium citrate, calcium succinate, hydrolyzable polyamines, poly(N-vinyl carbazole), poly(acrylic acid), poly(acrylamide), and mixtures thereof.
Claim 13
Dependent Claim
38 words
The bone cement system of claim 2 wherein said buffering compound is selected from the group consisting of calcium carbonate, calcium phosphate, calcium acetate, calcium citrate, calcium succinate, and mixtures thereof; said alloy further comprising an osteoconductive composition.
Claim 14
Dependent Claim
21 words
The bone cement system of claim 2 wherein the particle size of said buffering compound is from about 5μ to 500μ.
Claim 15
Dependent Claim
13 words
The bone cement system of claim 12 wherein said osteoconductive composition comprises hydroxyapatite.
Claim 16
Dependent Claim
114 words
A three part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said three part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation and a therapeutically effective amount of a biologically active or therapeutic agent, wherein said biologically active or therapeutic agent is in a protective coating of said first bioerodible polymer; b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer; and c) a third part comprising crosslinking initiator.
Claim 17
Dependent Claim
114 words
A three part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said three part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation and a therapeutically effective amount of a biologically active or therapeutic agent, wherein said biologically active or therapeutic agent is in a protective coating of said first bioerodible polymer; b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer; and c) a third part comprising crosslinking initiator.
Claim 18
Dependent Claim
33 words
The bone cement system of claim 15 further comprising in one of said parts a buffering compound in sufficiently high concentration so as to buffer said acidic products within a desired pH range.
Claim 19
Dependent Claim
16 words
The bone cement system of claim 15 wherein said second bioerodible polymer comprises polypropylene fumarate (PPF).
Claim 20
Dependent Claim
15 words
The bone cement system of claim 15 wherein said slinking agent is a vinyl monomer.
Claim 21
Dependent Claim
14 words
The bone cement system of claim 18 wherein said crosslinking agent is vinyl pyrrolidone.
Claim 22
Dependent Claim
15 words
The bone cement system of claim 18 wherein said crosslinking agent is methyl methacrylate (MMA).
Claim 23
Dependent Claim
29 words
The bone cement system of claim 15 wherein said biologically active or therapeutic agent is selected from the group consisting of bone repair proteins, antibiotics, cells, and mixtures thereof.
Claim 24
Dependent Claim
19 words
The bone cement system of claim 15 wherein said first bioerodible polymer is different from said second bioerodible polymer.
Claim 25
Dependent Claim
41 words
The bone cement system of claim 15 wherein said first bioerodible polymer is selected from the group consisting of poly(lactide-co-glycolide) (PLGA); polydioxanone; poly(ε-caprolactone); polyanhydrides; poly(ortho esters); copoly(ether-esters); polyamides; polylactones; polypropylene fumarates (H(--O--CH(CH 3 )--CH 2 --O--CO--CH═CH--CO--) n OH); and combinations thereof.
Claim 26
Dependent Claim
39 words
The bone cement system of claim 16 wherein said buffering compound that buffers said acidic products within a desired pH range is selected from the group consisting of inorganic acid salts; organic acid salts; and polymeric organic acid salts.
Claim 27
Dependent Claim
38 words
The bone cement system of claim 16 wherein said buffering compound is selected from the group consisting of calcium carbonate, calcium phosphate, calcium acetate, calcium citrate, calcium succinate, hydrolyzable polyamines, poly(N-vinyl carbazole), poly(acrylic acid), poly(acrylamide), and mixtures thereof.
Claim 28
Dependent Claim
38 words
The bone cement system of claim 16 wherein said buffering compound is selected from the group consisting of calcium carbonate, calcium phosphate, calcium acetate, calcium citrate, calcium succinate, and mixtures thereof; said alloy further comprising an osteoconductive composition.
Claim 29
Dependent Claim
21 words
The bone cement system of claim 16 wherein the particle size of said buffering compound is from about 5μ to 500μ.
Claim 30
Dependent Claim
13 words
The bone cement system of claim 26 wherein said osteoconductive composition comprises hydroxyapatite.
Claim 31
Dependent Claim
100 words
A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, crosslinking initiator, a therapeutically effective amount of a biologically active or therapeutic agent and a combination of citric acid and sodium bicarbonate; and b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer.
Claim 32
Dependent Claim
100 words
A two part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said two part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, crosslinking initiator, a therapeutically effective amount of a biologically active or therapeutic agent and a combination of citric acid and sodium bicarbonate; and b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer.
Claim 33
Dependent Claim
94 words
A three part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said three part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, and a combination of citric acid and sodium bicarbonate; b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer; and c) a third part comprising crosslinking initiator.
Claim 34
Dependent Claim
94 words
A three part bioerodible bone cement system which, upon mixing of the system parts, forms a bioerodible polymeric semi-IPN alloy, said three part cement system consisting of a) a first part comprising a first bioerodible polymer capable of producing acidic products upon hydrolytic degradation, and a combination of citric acid and sodium bicarbonate; b) a second part comprising a second bioerodible scaffolding polymer, which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for said semi-IPN alloy, and crosslinking agent for said second bioerodible scaffolding polymer; and c) a third part comprising crosslinking initiator.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2003-06-06 | 2003-12-06 | 2004-06-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-06-06 | 2007-12-06 | 2008-06-06 | $3760.00 | Window Closed / Lapsed |
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