US5336505A
Expired / Lapsed
US
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Bioerodible polymers useful for the controlled release of therapeutic agents
Assignee: PHARMACEUTICAL DELIVERY SYSTEM
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Filing: 1991-07-08
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Granted: 1994-08-09
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Expires: 2011-07-08
Abstract
Abstract Bioerodible ortho ester polymers useful for preparing bioerodible pharmaceutical compositions such as implants, ointments, creams, gels and the like are provided. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes, such as for the treatment of deep wounds, including burns, and for the treatment of periodontal disease.
Inventors
- 👤 Steve Y. W. Ng
- 👤 Jorge Heller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:33
CPC Classifications
C; C08; C08G; C08G65/00; A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K31/00; A61K31/56; A61K31/57; A61K47/00; A61K47/30; A61K47/34; A61K9/0019; A61K9/0024; A61K9/0053; A61K9/0063; A61K9/06; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/204; A61L; A61L26/00; A61L26/0061; A61L26/0066; A61L26/009; C08G65/34; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/43; A61L2300/60; A61L2300/602
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
27 words
A polymer comprising repeating mer units of the structure ##STR25## wherein R is hydrogen or (C 1 -C 10 )alkyl and A* is ##STR26## and mixtures thereof.
Claim 2
Dependent Claim
27 words
A polymer comprising repeating mer units of the structure ##STR25## wherein R is hydrogen or (C 1 -C 10 )alkyl and A* is ##STR26## and mixtures thereof.
Claim 3
Dependent Claim
15 words
The polymer of claim 1, wherein R comprises hydrogen or (C 1 -C 6 )alkyl.
Claim 4
Dependent Claim
25 words
The polymer of claim 1, having a molecular weight of at least about 500 and up to about 50,000, as determined by gel permeation chromatography.
Claim 5
Dependent Claim
25 words
The polymer of claim 3, having a molecular weight of at least about 2000 and up to about 50,000, as determined by gel permeation chromatography.
Claim 6
Dependent Claim
12 words
The polymer of claim 1, comprising about 5 to 1000 mer units.
Claim 7
Dependent Claim
12 words
The polymer of claim 5, comprising up to about 150 mer units.
Claim 8
Dependent Claim
16 words
A bioerodible composition comprising the bioerodible polymer of claim 1 or mixtures thereof and an excipient.
Claim 9
Dependent Claim
21 words
The bioerodible composition of claim 7, wherein the excipient is selected from the group consisting of neutral, acidic and alkaline excipients.
Claim 10
Dependent Claim
24 words
The bioerodible composition of claim 8, further comprising an agent selected from the group consisting of colorants, diluents, odorants, skin permeation enhancers and stabilizers.
Claim 11
Dependent Claim
16 words
A controlled release composition, comprising a therapeutic agent dispersed in the bioerodible composition of claim 7.
Claim 12
Dependent Claim
21 words
The controlled release composition of claim 10 in unit form, wherein the therapeutic agent is present in an effective therapeutic amount.
Claim 13
Dependent Claim
18 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises a wound or burn treating agent.
Claim 14
Dependent Claim
14 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises a protein.
Claim 15
Dependent Claim
15 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises an antiinfective agent.
Claim 16
Dependent Claim
16 words
The controlled release composition of claim 10, wherein the antiinfective agent comprises antibacterial or antiviral agents.
Claim 17
Dependent Claim
15 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises an antiinflammatory agent.
Claim 18
Dependent Claim
15 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises an antihypertensive agent.
Claim 19
Dependent Claim
15 words
The controlled release composition of claim 10, wherein the therapeutic agent comprises an adrenal corticosteriod.
Claim 20
Dependent Claim
15 words
The composition of claim 10, wherein the therapeutic agent comprises a periodontal disease treating agent.
Claim 21
Dependent Claim
11 words
The controlled release composition of claim 10, in solid implantable form.
Claim 22
Dependent Claim
10 words
The controlled release composition of claim 10, in flexible form.
Claim 23
Dependent Claim
13 words
The controlled release composition of claim 10, in a soft malleable dosage form.
Claim 24
Dependent Claim
24 words
The controlled release composition of claim 22, wherein the soft malleable dosage form is selected from the group consisting of ointments, creams and gels.
Claim 25
Dependent Claim
13 words
The controlled release composition of claim 10, in transdermal, transmucosal or intraocular form.
Claim 26
Dependent Claim
37 words
The controlled release composition of claim 10, wherein the drug is present in an amount of about 0.001 to 79 wt %; and the polymer is present in an amount of about 25 to 100 wt %.
Claim 27
Dependent Claim
23 words
A method for the controlled release of a therapeutic agent, comprising administering to a patient the controlled release bioerodible composition of claim 10.
Claim 28
Dependent Claim
24 words
A method of treating wounds or burns, comprising administering to a patient an effective amount of the controlled release bioerodible composition of claim 12.
Claim 29
Dependent Claim
24 words
A method for treating periodontal disease, comprising administering to an affected patient an effective amount of the controlled release bioerodible composition of claim 19.
Claim 30
Independent Claim
69 words
A method of preparing a bioerodible polymer, comprising contacting a monomeric orthoester of the chemical formula ##STR27## wherein R is hydrogen or (C 1 -C 10 )alkyl and R' is lower alkyl, with a triol having the chemical formula ##STR28## wherein A* is a mono- or dialkyleneclohexylene such that the triol has the structure ##STR29## to form a bioerodible orthoester polymer comprising mer units of the chemical structure ##STR30##
Claim 31
Independent Claim
69 words
A method of preparing a bioerodible polymer, comprising contacting a monomeric orthoester of the chemical formula ##STR27## wherein R is hydrogen or (C 1 -C 10 )alkyl and R' is lower alkyl, with a triol having the chemical formula ##STR28## wherein A* is a mono- or dialkyleneclohexylene such that the triol has the structure ##STR29## to form a bioerodible orthoester polymer comprising mer units of the chemical structure ##STR30##
Claim 32
Dependent Claim
12 words
The method of claim 29, wherein R is hydrogen or lower alkyl.
Claim 33
Dependent Claim
21 words
The method of claim 30, wherein the number of mer units in the final polymer obtained is about 5 to 1000.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-08 | 1998-02-07 | 1998-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-08 | 2002-02-07 | 2002-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-08 | 2006-02-07 | 2006-08-09 | $7700.00 | Window Closed / Lapsed |