US6020380A
Expired / Lapsed
US
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Method of treating chronic obstructive pulmonary disease
Assignee: Abbott Laboratories
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Filing: 1998-11-25
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Granted: 2000-02-01
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Expires: 2018-11-25
Abstract
Abstract A class of OMEGA -substituted-1,4-benzoquinon-2-yl]alkanoic acids are useful in the treatment of chronic obstructive pulmonary disease (COPD). The preferred compound for the method of treatment is 7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt, ester or pro-drug thereof.
Inventors
- 👤 Anthony Killian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:59
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/192; A61P; A61P11/00; A61P11/06; A61P11/08
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
85 words
A method of treating chronic obstructive pulmonary disease in a patient in need of such treatment comprising administering a therapeutically effective amount of a compound of the formula: ##STR2## or pharmaceutically acceptable salt or pro-drug thereof, wherein the asterisk denotes a chiral center, and R 1 is selected from the group consisting of unsubstituted phenyl; phenyl substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, alkyl of one to three carbon atoms, alkoxy of one to three carbon atoms.
Claim 2
Independent Claim
85 words
A method of treating chronic obstructive pulmonary disease in a patient in need of such treatment comprising administering a therapeutically effective amount of a compound of the formula: ##STR2## or pharmaceutically acceptable salt or pro-drug thereof, wherein the asterisk denotes a chiral center, and R 1 is selected from the group consisting of unsubstituted phenyl; phenyl substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, alkyl of one to three carbon atoms, alkoxy of one to three carbon atoms.
Claim 3
Dependent Claim
21 words
A method according to claim 1 wherein said patient in need of treatment suffers from airway obstruction associated with chronic bronchitis.
Claim 4
Dependent Claim
20 words
A method according to claim 1 wherein said patient in need of treatment suffers from airway obstruction associated with emphysema.
Claim 5
Dependent Claim
24 words
A method according to claim 1 wherein said patient in need of treatment suffers from airway obstruction associated with both chronic bronchitis and emphysema.
Claim 6
Dependent Claim
15 words
The method according to claim 2 wherein said patient in need of treatment is asthmatic.
Claim 7
Dependent Claim
15 words
The method according to claim 3 wherein said patient in need of treatment is asthmatic.
Claim 8
Dependent Claim
15 words
The method according to claim 4 wherein said patient in need of treatment is asthmatic.
Claim 9
Independent Claim
38 words
A method of treating chronic obstructive pulmonary disease comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound having the name (±)7-(3.4.5-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 10
Independent Claim
38 words
A method of treating chronic obstructive pulmonary disease comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound having the name (±)7-(3.4.5-trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 11
Dependent Claim
21 words
A method according to claim 8 wherein said patient in need of treatment suffers from airway obstruction associated with chronic bronchitis.
Claim 12
Dependent Claim
20 words
A method according to claim 8 wherein said patient in need of treatment suffers from airway obstruction associated with emphysema.
Claim 13
Dependent Claim
24 words
A method according to claim 8 wherein said patient in need of treatment suffers from airway obstruction associated with both chronic bronchitis and emphysema.
Claim 14
Dependent Claim
15 words
The method according to claim 9 wherein said patient in need of treatment is asthmatic.
Claim 15
Dependent Claim
15 words
The method according to claim 10 wherein said patient in need of treatment is asthmatic.
Claim 16
Dependent Claim
15 words
The method according to claim 11 wherein said patient in need of treatment is asthmatic.
Claim 17
Independent Claim
38 words
A method of treating chronic obstructive pulmonary disease comprising administering to a patient in need of such treatment a therapaeutically effective amount of a compound having the name R(+)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenyl-heptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 18
Independent Claim
38 words
A method of treating chronic obstructive pulmonary disease comprising administering to a patient in need of such treatment a therapaeutically effective amount of a compound having the name R(+)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenyl-heptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 19
Dependent Claim
21 words
A method according to claim 15 wherein said patient in need of treatment suffers from airway obstruction associated with chronic bronchitis.
Claim 20
Dependent Claim
20 words
A method according to claim 15 wherein said patient in need of treatment suffers from airway obstruction associated with emphysema.
Claim 21
Dependent Claim
24 words
A method according to claim 15 wherein said patient in need of treatment suffers from airway obstruction associated with both chronic bronchitis and emphysema.
Claim 22
Dependent Claim
15 words
The method according to claim 16 wherein said patient in need of treatment is asthmatic.
Claim 23
Dependent Claim
15 words
The method according to claim 17 wherein said patient in need of treatment is asthmatic.
Claim 24
Dependent Claim
15 words
The method according to claim 18 wherein said patient in need of treatment is asthmatic.
Claim 25
Independent Claim
45 words
A method of treating chronic obstructive pulmonary disease comprising orally administering to a patient in need of such treatment a daily dose ranging between about 50 and 1000 mg of a compound having the name (±)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenyl-heptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 26
Independent Claim
45 words
A method of treating chronic obstructive pulmonary disease comprising orally administering to a patient in need of such treatment a daily dose ranging between about 50 and 1000 mg of a compound having the name (±)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7-phenyl-heptanoic acid or a pharmaceutically acceptable salt or pro-drug thereof.
Claim 27
Dependent Claim
13 words
The method according to claim 22 wherein the method of administration is orally.
Claim 28
Dependent Claim
19 words
The method of claim 22 wherein said compound is the (R+)-enantiomer or a pharmaceutically acceptable salt or pro-drug thereof.
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