Patent US1809866A successfully refreshed from Google Patents.
Patent US5945115A successfully refreshed from Google Patents.
US5945115A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric compositions useful as controlled release implants
Assignee: Tolmar Therapeutics Inc
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Filing: 1997-08-08
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Granted: 1999-08-31
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Expires: 2017-08-08
Abstract
Abstract The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.
Inventors
- 👤 Richard L. Dunn
- 👤 Arthur J. Tipton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K47/30; A61K47/34
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
79 words
A composition suitable for in situ formation of an implant in an animal, comprising: (a) a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in aqueous or body fluids; (b) a biocompatible organic solvent which solubilizes the thermoplastic polymer, is miscible to dispersible in aqueous or body fluids, and is capable of dissipating from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms the implant; and (c) a biologically active agent capable of enhancing bone growth.
Claim 2
Dependent Claim
79 words
A composition suitable for in situ formation of an implant in an animal, comprising: (a) a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in aqueous or body fluids; (b) a biocompatible organic solvent which solubilizes the thermoplastic polymer, is miscible to dispersible in aqueous or body fluids, and is capable of dissipating from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms the implant; and (c) a biologically active agent capable of enhancing bone growth.
Claim 3
Dependent Claim
12 words
The composition of claim 1, further comprising a release rate modifying agent.
Claim 4
Dependent Claim
14 words
The composition of claim 1 wherein the biologically active material is demineralized bone matrix.
Claim 5
Dependent Claim
14 words
The composition of claim 1 wherein the biological active material is bone morphogenic protein.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-08-30 | 2003-03-01 | 2003-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-08-30 | 2007-03-01 | 2007-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-08-30 | 2011-03-01 | 2011-08-31 | $7700.00 | Window Closed / Lapsed |