US5925016A
Expired / Lapsed
US
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Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
Assignee: Medtronic Vascular Inc
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Filing: 1995-09-27
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Granted: 1999-07-20
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Expires: 2015-09-27
Abstract
Abstract Systems and methods for treating thrombosis by driving the drugs or lytic agents through the thrombus by pressure, are disclosed. The system preferably comprises a guide catheter with an occlusion balloon for isolating the region proximal to the thrombus, a guide wire with an occlusion balloon for isolating the region distal to the thrombus and an infusion catheter for delivering drugs or other agents into the region distal to the thrombus under pressure. A lumen of the guide catheter is preferably provided to evacuate material proximal to the thrombus, decreasing the pressure in the proximal to the thrombus. The lumen can be coupled to a thrombus filter to remove thrombolytic material from the drug or lytic agent evacuated from the proximal region. The filtered drug or lytic agent can then be redelivered into the distal region. Recycling of the drug or lytic agent in this manner decreases the costs of the procedure. The systems and methods of the invention can be used to treat other blockages in lumens or vessels in the body or to deliver drugs or other agents to lumens, vessels or cavities within the body, as well.
Inventors
- 👤 Victor I. Chornenky
- 👤 Michael R. Forman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:25
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/09; A61M25/10; A61M25/0043; A61M25/0045; A61M2025/0046; A61M2025/0047; A61M2025/09008; A61M2025/09058; A61M2025/09083; A61M2025/1043; A61M2025/1052; A61M2205/00; A61M2205/36; A61M25/0067; A61M25/0068; A61M25/007; A61M25/1011
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
95 words
A system for treating a blockage in a lumen, vessel or cavity comprising: means for delivering a drug or other agent to a first region proximate the blockage, means for forcing the drug or other agent from the first region through the thrombus, comprising a pump in fluid communication with the first region which delivers drugs or other agents into the first region under pressure; means for occluding the region; and a filter coupled to the means for delivering such that filtered material comprising filtered drug or other agent is delivered to the first region.
Claim 2
Independent Claim
95 words
A system for treating a blockage in a lumen, vessel or cavity comprising: means for delivering a drug or other agent to a first region proximate the blockage, means for forcing the drug or other agent from the first region through the thrombus, comprising a pump in fluid communication with the first region which delivers drugs or other agents into the first region under pressure; means for occluding the region; and a filter coupled to the means for delivering such that filtered material comprising filtered drug or other agent is delivered to the first region.
Claim 3
Independent Claim
155 words
A system for treating thrombosis comprising: at least one inflation/deflation unit; a first occlusion balloon coupled to the inflation/deflation unit, such that the first occlusion balloon can isolate a region distal to a thrombus; a second occlusion balloon coupled to the inflation/deflation unit, such that the second occlusion balloon can isolate a second region proximal to the thrombus; a pump; a first lumen coupled to the pump and the first region, wherein a drug or lytic agent can be infused into the first region through the first lumen under pressure by the pump, to force the drug or other agent through the thrombus; a second lumen coupled to the pump and the second region wherein the material can be evacuated from the second region; and a filter between the second lumen and the pump, such that material evacuated from the second region is filtered prior to infusion into the first region through the first lumen.
Claim 4
Independent Claim
155 words
A system for treating thrombosis comprising: at least one inflation/deflation unit; a first occlusion balloon coupled to the inflation/deflation unit, such that the first occlusion balloon can isolate a region distal to a thrombus; a second occlusion balloon coupled to the inflation/deflation unit, such that the second occlusion balloon can isolate a second region proximal to the thrombus; a pump; a first lumen coupled to the pump and the first region, wherein a drug or lytic agent can be infused into the first region through the first lumen under pressure by the pump, to force the drug or other agent through the thrombus; a second lumen coupled to the pump and the second region wherein the material can be evacuated from the second region; and a filter between the second lumen and the pump, such that material evacuated from the second region is filtered prior to infusion into the first region through the first lumen.
Claim 5
Dependent Claim
21 words
The system of claim 2, further comprising a guide catheter, wherein the first occlusion balloon is part of the guide catheter.
Claim 6
Dependent Claim
21 words
The system of claim 2, further comprising an infusion catheter, wherein the first occlusion balloon is part of the infusion catheter.
Claim 7
Dependent Claim
20 words
The system of claim 2, further comprising an infusion catheter, wherein the first lumen is part of the infusion catheter.
Claim 8
Dependent Claim
20 words
The system of claim 2, further comprising a guide wire, wherein the first lumen is part of the guide wire.
Claim 9
Dependent Claim
21 words
The system of claim 2, further comprising an infusion catheter, wherein the second occlusion balloon is coupled to the infusion catheter.
Claim 10
Dependent Claim
21 words
The system of claim 2, further comprising a guide wire, wherein the second occlusion balloon is coupled to the guide wire.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-07-19 | 2003-01-18 | 2003-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-07-19 | 2007-01-18 | 2007-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-07-19 | 2011-01-18 | 2011-07-20 | $7700.00 | Window Closed / Lapsed |