US5914356A
Expired / Lapsed
US
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Bioactive load bearing bone bonding compositions
Assignee: PAUL ROYALTY FUND LP
•
Filing: 1996-12-06
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Granted: 1999-06-22
•
Expires: 2016-12-06
Abstract
Abstract Novel fillers comprising combeite glass-ceramic are provided, along with filled polymerizable resin composites. Further provided are methods for making the combeite crystallite-containing novel fillers for use in hardenable, biocompatible bone restorations. Hard, shaped bodies or orthopaedic, dental and other uses are also provided.
Inventors
- 👤 Erik M. Erbe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/0047; A61L24/0073; A61L24/0089; A61K; A61K6/00; A61K6/80; A61K6/884; A61K6/887; A61L24/02; C; C03; C03C; C03C10/00; C03C10/0009; C03C4/00; C03C4/0007; C03C4/0021
Claims Analysis
Total Claims: 57
Claim 1
Independent Claim
15 words
A glass-ceramic composition comprising heterogeneous particles having an irregular morphology and regions of combeite crystallites.
Claim 2
Dependent Claim
15 words
A glass-ceramic composition comprising heterogeneous particles having an irregular morphology and regions of combeite crystallites.
Claim 3
Dependent Claim
18 words
The composition of claim 1 wherein combeite comprises at least about 2 percent by volume of the particles.
Claim 4
Dependent Claim
18 words
The composition of claim 1 wherein combeite comprises at least about 3 percent by volume of the particles.
Claim 5
Dependent Claim
18 words
The composition of claim 1 wherein combeite comprises at least about 5 percent by volume of the particles.
Claim 6
Dependent Claim
18 words
The composition of claim 1 wherein combeite comprises at least about 10 percent by volume of the particles.
Claim 7
Dependent Claim
19 words
The composition of claim 1 wherein combeite comprises between about 5 and 50 percent by volume of the particles.
Claim 8
Dependent Claim
21 words
The composition of claim 1 wherein at least 95% by weight of said particles have sizes greater than about 0.1 micron.
Claim 9
Dependent Claim
21 words
The composition of claim 1 wherein at least 95% by weight of said particles have sizes greater than about 0.2 micron.
Claim 10
Dependent Claim
21 words
The composition of claim 1 wherein at least 95% by weight of said particles have sizes less than about 300 microns.
Claim 11
Dependent Claim
21 words
The composition of claim 1 wherein at least 95% by weight of said particles have sizes less than about 100 microns.
Claim 12
Dependent Claim
22 words
The composition of claim 1 wherein at least 95% by weight of said particles have sizes between about 0.2 and 300 microns.
Claim 13
Dependent Claim
23 words
The composition of claim 1 wherein at least 95% by weight of said particles have particle sizes between about 0.5 and 50 microns.
Claim 14
Dependent Claim
14 words
The composition of claim 5 in the form of a blend of particle sizes.
Claim 15
Independent Claim
42 words
A method for restoring bone comprising applying to said bone a hardenable composition comprising a polymerizable matrix and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite.
Claim 16
Independent Claim
42 words
A method for restoring bone comprising applying to said bone a hardenable composition comprising a polymerizable matrix and inorganic filler, at least 10 percent of said filler comprising combeite glass-ceramic having at least about 2 percent by volume of regions of combeite.
Claim 17
Dependent Claim
19 words
The method of claim 14 wherein combeite comprises at least about 3 percent by volume of said combeite glass-ceramic.
Claim 18
Dependent Claim
19 words
The method of claim 14 wherein combeite comprises at least about 5 percent by volume of said combeite glass-ceramic.
Claim 19
Dependent Claim
19 words
The method of claim 14 wherein combeite comprises at least about 10 percent by volume of said combeite glass-ceramic.
Claim 20
Dependent Claim
20 words
The method of claim 14 wherein combeite comprises between about 5 and 50 percent by volume of said combeite glass-ceramic.
Claim 21
Dependent Claim
20 words
The method of claim 14 wherein combeite comprises between about 10 and 20 percent by volume of said combeite glass-ceramic.
Claim 22
Dependent Claim
17 words
The method of claim 14 wherein said combeite glass-ceramic is present in the form of heterogeneous particles.
Claim 23
Dependent Claim
22 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes greater than about 0.1 micron.
Claim 24
Dependent Claim
22 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes greater than about 0.2 micron.
Claim 25
Dependent Claim
21 words
The method of claim 20 wherein at least 95% by weight of said particles have-particle sizes less than about 300 microns.
Claim 26
Dependent Claim
22 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes less than about 100 microns.
Claim 27
Dependent Claim
23 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes between about 0.2 and 300 microns.
Claim 28
Dependent Claim
23 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes between about 0.2 and 100 microns.
Claim 29
Dependent Claim
23 words
The method of claim 20 wherein at least 95% by weight of said particles have particle sizes between about 0.5 and 50 microns.
Claim 30
Dependent Claim
21 words
The method of claim 14 wherein the combeite glass-ceramic filler has an X-ray diffraction spectrum substantially in accordance with FIG. 1b.
Claim 31
Dependent Claim
17 words
The method of claim 14 wherein said inorganic filler further comprises at least one additional inorganic material.
Claim 32
Dependent Claim
34 words
The method of claim 29 wherein said additional inorganic material is hydroxyapatite, fluorapatite, oxyapatite, Wollastonite, anorthite, calcium fluoride, agrellite, devitrite, canasite, phlogopite, monetite, brushite, octocalcium phosphate, Whitlockite, tetracalcium phosphate, cordierite, Berlinite or mixtures thereof.
Claim 33
Dependent Claim
12 words
The method of claim 14 wherein said polymerizable matrix comprises acrylic species.
Claim 34
Dependent Claim
13 words
The method of claim 14 wherein said polymerizable matrix comprises a bisphenol-A dimethacrylate.
Claim 35
Dependent Claim
14 words
The method of claim 14 wherein said bisphenol-A dimethacrylate is a bisphenol-A glycidyl dimethacrylate.
Claim 36
Dependent Claim
12 words
The method of claim 33 wherein said dimethacrylate has been urethane modified.
Claim 37
Dependent Claim
15 words
The method of claim 14 wherein the polymerizable matrix comprises a heat- or photo-polymerizing catalyst.
Claim 38
Dependent Claim
17 words
The method of claim 35 wherein said catalyst comprises a quinone in admixture with a tertiary amine.
Claim 39
Dependent Claim
11 words
The method of claim 35 wherein said catalyst comprises a peroxide.
Claim 40
Dependent Claim
21 words
The method of claim 14 wherein said composition has a viscosity amenable to spatulation or delivery via a wide mouth syringe.
Claim 41
Dependent Claim
17 words
The method of claim 38 wherein said composition has a viscosity between about 5,000 and 75,000 centipoise.
Claim 42
Dependent Claim
10 words
The method of claim 14 further comprising hardening said composition.
Claim 43
Independent Claim
150 words
A method for preparing a bioactive, inorganic, particulate filler comprising: melting together about 34 percent by weight SiO 2 , about 31 percent by weight Na 2 CO 3 , about 26.5 percent by weight CaCO 3 , and about 8.5 percent by weight CaHPO 4 for a time and under conditions effective to achieve substantial homogeneity; casting, crystallizing and cooling the melt into a body; comminuting said body to form particles having irregular morphology; determining the presence or absence and amount of regions of combeite crystallites in said particles; and in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
Claim 44
Independent Claim
150 words
A method for preparing a bioactive, inorganic, particulate filler comprising: melting together about 34 percent by weight SiO 2 , about 31 percent by weight Na 2 CO 3 , about 26.5 percent by weight CaCO 3 , and about 8.5 percent by weight CaHPO 4 for a time and under conditions effective to achieve substantial homogeneity; casting, crystallizing and cooling the melt into a body; comminuting said body to form particles having irregular morphology; determining the presence or absence and amount of regions of combeite crystallites in said particles; and in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
Claim 45
Dependent Claim
18 words
The method of claim 41 wherein said amount of regions is at least about 3 percent by volume.
Claim 46
Dependent Claim
18 words
The method of claim 41 wherein said amount of regions is at least about 5 percent by volume.
Claim 47
Dependent Claim
19 words
The method of claim 41 wherein said particles have an X-ray diffraction spectrum substantially in accordance with FIG. 1b.
Claim 48
Independent Claim
150 words
A method for preparing a bioactive, inorganic, particulate filler comprising: melting together about 45 percent by weight SiO 2 , about 24.5 percent by weight Na 2 O, about 24.5 percent by weight CaO, and about 6 percent by weight P 2 O 5 for a time and under conditions effective to achieve substantial homogeneity; quenching said melt in a fluid to form a frangible frit; comminuting said freL to form particles having irregular morphology; determining the presence or absence and amount of regions of combeite crystallites in said particles; and in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
Claim 49
Independent Claim
150 words
A method for preparing a bioactive, inorganic, particulate filler comprising: melting together about 45 percent by weight SiO 2 , about 24.5 percent by weight Na 2 O, about 24.5 percent by weight CaO, and about 6 percent by weight P 2 O 5 for a time and under conditions effective to achieve substantial homogeneity; quenching said melt in a fluid to form a frangible frit; comminuting said freL to form particles having irregular morphology; determining the presence or absence and amount of regions of combeite crystallites in said particles; and in response to a determination that the amount by volume of regions of combeite crystallites in said particles is less than a preselected value greater than 2 percent, heat treating said particles under conditions of time and temperature effective to provide said particles with an amount by volume of regions of combeite crystallites of at least said preselected value.
Claim 50
Dependent Claim
18 words
The method of claim 45 wherein said amount of regions is at least about 3 percent by volume.
Claim 51
Dependent Claim
18 words
The method of claim 45 wherein said amount of regions is at least about 5 percent by volume.
Claim 52
Dependent Claim
19 words
The method of claim 45 wherein said particles have an X-ray diffraction spectrum substantially in accordance with FIG. 1.
Claim 53
Dependent Claim
34 words
A shaped body comprising a polymerized matrix filled with an inorganic filler, at least 10% of said filler comprising combeite glass-ceramic having at least 2% by volume of regions of combeite and irregular morphology.
Claim 54
Dependent Claim
34 words
A shaped body comprising a polymerized matrix filled with an inorganic filler, at least 10% of said filler comprising combeite glass-ceramic having at least 2% by volume of regions of combeite and irregular morphology.
Claim 55
Dependent Claim
19 words
The shaped body of claim 49 in the form of an orthopaedic pin, screw, rod, plate, or joint member.
Claim 56
Dependent Claim
13 words
The shaped body of claim 49 in the form of an endodontic point.
Claim 57
Dependent Claim
13 words
The shaped body of claim 49 in the form of a orthopaedic appliance.
References Cited (Backward Citations)
US2208236A
Cited
US2920971A
Cited
US3629187A
Cited
US4110184A
Cited
US3981736A
Cited
US4239113A
Cited
US4396476A
Cited
US4396262A
Cited
US4411625A
Cited
US4491453A
Cited
US4698373A
Cited
US4801528A
Cited
US4775646A
Cited
US4643982A
Cited
US4652534A
Cited
US4851046A
Cited
US4886843A
Cited
US5238491A
Cited
US5204106A
Cited
US5145520A
Cited
US5236458A
Cited
WO1993016738A1
Cited
US5527836A
Cited
US5648301A
Cited
US5336642A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-06-21 | 2002-12-21 | 2003-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-06-21 | 2006-12-21 | 2007-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-06-21 | 2010-12-21 | 2011-06-22 | $7700.00 | Window Closed / Lapsed |