US5648301A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioactive material template for in vitro synthesis of bone tissue
Assignee: University of Pennsylvania
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Filing: 1995-06-02
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Granted: 1997-07-15
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Expires: 2015-06-02
Abstract
Abstract Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO 2 , CaO, Na 2 O and P 2 O 5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.
Inventors
- 👤 Paul Ducheyne
- 👤 Ahmed El-Ghannam
- 👤 Irving Shapiro
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:00
CPC Classifications
C; C03; C03C; C03C11/00; C12; C12N; C12N5/00; C12N5/06; C12N5/0602; C12N5/0652; A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61L; A61L27/00; A61L27/02; A61L27/025; A61L27/10; A61L27/12; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/38; A61L27/3804; A61L27/3821; A61L27/3839; A61L27/3843; A61L27/3847; C03C3/00; C03C3/04; C03C3/076; C03C3/097; C03C4/00; C03C4/0007; C12N5/0068; C12N5/0654; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61F2310/00329; A61L2430/00; A61L2430/02; C12N2533/00; C12N2533/10; C12N2533/12; Y; Y10; Y10S; Y10S623/00; Y10S623/92
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
62 words
A porous bioactive substrate comprising a glass having the following composition: 40-60% by weight SiO 2 ; 10-35% by weight CaO; 5-30% by weight Na 2 O; and 0-12% by weight P 2 O 5 , said substrate having a porosity of from about 10 to about 80% and a pore size of less than about 800 μm, and substantially no crystallization.
Claim 2
Dependent Claim
62 words
A porous bioactive substrate comprising a glass having the following composition: 40-60% by weight SiO 2 ; 10-35% by weight CaO; 5-30% by weight Na 2 O; and 0-12% by weight P 2 O 5 , said substrate having a porosity of from about 10 to about 80% and a pore size of less than about 800 μm, and substantially no crystallization.
Claim 3
Dependent Claim
14 words
The substrate of claim 1 wherein porosity is from about 20 to about 30%.
Claim 4
Dependent Claim
21 words
The substrate of claim 1 wherein the pore size is in the range of from about 75 to about 200 μm.
Claim 5
Dependent Claim
37 words
The substrate of claim 1 wherein the glass has the following composition: 45% by weight SiO 2 ; 24.5% by weight CaO; 24.5% by weight Na 2 O; and 6% by weight P 2 O 5 .
Claim 6
Dependent Claim
128 words
A porous bioactive substrate comprising a glass consisting essentially of: 40-60% by weight SiO 2 ; 10-35% by weight CaO; 5-30% by weight Na 2 O; and 0-12% by weight P 2 O 5 , said substrate having a porosity of from about 10 to about 80% and a pore size of less than about 800 μm, wherein said substrate is prepared by the process comprising the steps of: a) melting an admixture consisting essentially of SiO 2 , Na 2 O, CaO, and P 2 O 5 ; b) quenching the melted admixture to create a glass frit; c) forming a glass powder from the glass frit; and d) forming a porous glass substrate from the glass powder, whereby the resulting porous glass exhibits substantially no crystallization.
Claim 7
Dependent Claim
128 words
A porous bioactive substrate comprising a glass consisting essentially of: 40-60% by weight SiO 2 ; 10-35% by weight CaO; 5-30% by weight Na 2 O; and 0-12% by weight P 2 O 5 , said substrate having a porosity of from about 10 to about 80% and a pore size of less than about 800 μm, wherein said substrate is prepared by the process comprising the steps of: a) melting an admixture consisting essentially of SiO 2 , Na 2 O, CaO, and P 2 O 5 ; b) quenching the melted admixture to create a glass frit; c) forming a glass powder from the glass frit; and d) forming a porous glass substrate from the glass powder, whereby the resulting porous glass exhibits substantially no crystallization.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-07-14 | 2001-01-13 | 2001-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-07-14 | 2005-01-13 | 2005-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-07-14 | 2009-01-13 | 2009-07-15 | $7700.00 | Window Closed / Lapsed |