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US5869602A
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Peptide derivatives
Assignee: Novo Nordisk AS
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Filing: 1995-05-23
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Granted: 1999-02-09
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Expires: 2015-05-23
Abstract
Abstract The present invention relates to a pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.
Inventors
- 👤 Ib Jonassen
- 👤 Svend Havelund
- 👤 Per Hertz Hansen
- 👤 Peter Kurtzhals
- 👤 John Halstr.o slashed.m
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:12
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/26; A61K38/2242; A61K38/31; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/64; A61P; A61P25/00; A61P25/04; A61P3/00; A61P3/08; A61P3/10; A61P3/12; A61P3/14; A61P31/00; A61P31/12; A61P39/00; A61P39/06; A61P5/00; A61P5/02; A61P5/10; A61P5/14; A61P5/18; A61P5/22; A61P5/38; A61P5/48; A61P5/50; A61P7/00; A61P7/06; A61P9/00; A61P9/12; C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/665; A61K38/04; A61K38/08; A61K38/095
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
73 words
A peptide derivative which is: Lys 30 (N.sup.ε -lipophilic substituent) glucagon, wherein the lipophilic substituent has 8 to 40 carbon atoms and (a) is a straight chain fatty acid or (b) consists of a spacer selected from the group consisting of Glu and Asp, wherein said spacer forms one amide bond with the ε-amino group of Lys 30 and a further amide bond with the carboxyl group of a straight chain fatty acid.
Claim 2
Dependent Claim
73 words
A peptide derivative which is: Lys 30 (N.sup.ε -lipophilic substituent) glucagon, wherein the lipophilic substituent has 8 to 40 carbon atoms and (a) is a straight chain fatty acid or (b) consists of a spacer selected from the group consisting of Glu and Asp, wherein said spacer forms one amide bond with the ε-amino group of Lys 30 and a further amide bond with the carboxyl group of a straight chain fatty acid.
Claim 3
Dependent Claim
12 words
The peptide derivative of claim 1, wherein the lipophilic substituent is tetradecanoyl.
Claim 4
Dependent Claim
12 words
The peptide derivative of claim 2, wherein the lipophilic substituent is decanoyl.
References Cited (Backward Citations)
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WO1993021320A1
Cited
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Cited
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-08 | 2002-08-10 | 2003-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-08 | 2006-08-10 | 2007-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-08 | 2010-08-10 | 2011-02-09 | $7700.00 | Window Closed / Lapsed |