Patent US5846513A successfully refreshed from Google Patents.
US5846513A
Expired / Lapsed
US
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Tumor localization and removal system using penetratable detection probe and removal instrument
Assignee: Southern Scientific Ltd
•
Filing: 1997-07-08
•
Granted: 1998-12-08
•
Expires: 2017-07-08
Abstract
Abstract A system for detecting and destroying living tumor tissue within the body of a living being. The system is arranged to be used with a tumor localizing radiopharmaceutical. The system includes a percutaneously insertable radiation detecting probe, an associated analyzer, and a percutaneously insertable tumor removing instrument, e.g., a resectoscope. The radiation detecting probe includes a needle unit having a radiation sensor component therein and a handle to which the needle unit is releasably mounted. The needle is arranged to be inserted through a small percutaneous portal into the patient's body and is movable to various positions within the suspected tumor to detect the presence of radiation indicative of cancerous tissue. The probe can then be removed and the tumor removing instrument inserted through the portal to destroy and/or remove the cancerous tissue. The instrument not only destroys the tagged tissue, but also removes it from the body of the being so that it can be assayed for radiation to confirm that the removed tissue is cancerous and not healthy tissue. A collimator may be used with the probe to establish the probe's field of view.
Inventors
- 👤 Robert G. Carroll
- 👤 Robin A. Wise, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:23
CPC Classifications
A; A61; A61B; A61B10/00; A61B10/02; A61B10/0233; A61B10/0266; A61B10/0275; A61B6/00; A61B6/40; A61B6/4057; A61B6/42; A61B6/4208; A61B6/425; A61B6/4258; A61B6/44; A61B6/4423; A61B6/48; A61B6/482; G; G01; G01T; G01T1/00; G01T1/16; G01T1/161; A61B90/00; A61B90/39; A61B2090/3904; A61B2090/3908; A61B6/4488
Claims Analysis
Total Claims: 98
Claim 1
Independent Claim
156 words
A system for determining the three dimensional representation of living tumor tissue within the body of a living being, said system comprising a tumor localizing radiopharmaceutical and small diameter penetratable radiation detecting means, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said tumor-localizing radiation comprising photons of different energies produced by said radiopharmaceutical, said small diameter penetratable radiation detecting means being arranged to be inserted into the body of the being with minimal invasion of the being via a percutaneous incision or access port and being movable along a path within the tumor tissue for location at various positions within the tumor tissue for detecting said tumor localizing radiation from a plurality of directions therein to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 2
Independent Claim
156 words
A system for determining the three dimensional representation of living tumor tissue within the body of a living being, said system comprising a tumor localizing radiopharmaceutical and small diameter penetratable radiation detecting means, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said tumor-localizing radiation comprising photons of different energies produced by said radiopharmaceutical, said small diameter penetratable radiation detecting means being arranged to be inserted into the body of the being with minimal invasion of the being via a percutaneous incision or access port and being movable along a path within the tumor tissue for location at various positions within the tumor tissue for detecting said tumor localizing radiation from a plurality of directions therein to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 3
Dependent Claim
38 words
The system of claim 1 wherein said penetratable radiation detecting means is an elongated member having a longitudinal axis arranged to be located along said path and to be rotated about said longitudinal axis to various angular positions.
Claim 4
Dependent Claim
39 words
The system of claim 1 wherein said penetratable radiation detecting means is an elongated member having a longitudinal axis and arranged to penetrate the tumor tissue and be moved within the tumor tissue to various positions along said path.
Claim 5
Dependent Claim
24 words
The system of claim 3 wherein said penetratable radiation detecting means is arranged to be rotated about said longitudinal axis to various angular positions.
Claim 6
Dependent Claim
16 words
The system of claim 1 additionally comprising tissue destroying means for destroying the living tumor tissue.
Claim 7
Dependent Claim
21 words
The system of claim 5 wherein said tissue destroying means is arranged for providing a dose of a necrotizing agent therefrom.
Claim 8
Dependent Claim
13 words
The system of claim 6 wherein said necrotizing agent comprises a radioactive agent.
Claim 9
Dependent Claim
40 words
The system of claim 7 wherein said radioactive agent is in a locally persistent form arranged for location adjacent the situs of the living tumor tissue, whereupon said radioactive agent produces radiation emissions therefrom to necrotize the living tumor tissue.
Claim 10
Dependent Claim
44 words
The system of claim 7 wherein said radioactive agent produces emissions of one or more selected from the group consisting of alpha rays, beta rays, gamma rays, x rays, and neutrons, and wherein said necrotizing means provides said emissions to the living tumor tissue.
Claim 11
Dependent Claim
13 words
The system of claim 6 wherein said necrotizing agent comprises a pharmacologic substance.
Claim 12
Dependent Claim
26 words
The system of claim 6 wherein said necrotizing agent comprises ultrasonic waves, and wherein said necrotizing means provides said ultrasonic waves to the living tumor tissue.
Claim 13
Dependent Claim
27 words
The system of claim 6 wherein said necrotizing agent comprises a laser beam, and wherein said necrotizing means provides said laser beam to the living tumor tissue.
Claim 14
Dependent Claim
25 words
The system of claim 6 wherein said necrotizing agent is thermal, and wherein said necrotizing means provides said thermal agent to the living tumor tissue.
Claim 15
Dependent Claim
18 words
The system of claim 13 wherein said thermal agent necrotizes the living tumor tissue by the heating it.
Claim 16
Dependent Claim
17 words
The system of claim 13 wherein said thermal agent necrotizes the living tumor tissue by cooling it.
Claim 17
Dependent Claim
26 words
The system of claim 1 additionally comprising means for removing at least a portion of the living tumor tissue from the body of the living being.
Claim 18
Dependent Claim
15 words
The system of claim 16 wherein said means for removing operates on a continuing basis.
Claim 19
Dependent Claim
21 words
The system of claim 16 additionally comprising means for determining if said removed portion of the living tumor tissue is radioactive.
Claim 20
Dependent Claim
44 words
The system of claim 1 wherein said penetratable radiation detecting means is arranged for detecting said tumor localizing radiation from a plurality of directions therein utilizing the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical as a reference factor.
Claim 21
Dependent Claim
31 words
The system of claim 19 additionally comprising tissue destroying means for destroying the living tumor tissue, said tissue destroying means being arranged for percutaneous introduction into the body of the being.
Claim 22
Dependent Claim
36 words
The system of claim 1 wherein said penetratable radiation detecting means is an elongated device having a longitudinal axis, and a sensor having a predetermined field of view for detecting radiation with said field of view.
Claim 23
Dependent Claim
16 words
The system of claim 21 wherein said field of view extends laterally of said longitudinal axis.
Claim 24
Dependent Claim
15 words
The system of claim 21 additionally comprising collimator means for limiting said field of view.
Claim 25
Dependent Claim
14 words
The system of claim 21 wherein said penetratable radiation detecting means comprises a needle.
Claim 26
Dependent Claim
48 words
The system of claim 21 additionally comprising radiation detection enhancing means comprising a barrier wall disposed adjacent said sensor for blocking radiation to said sensor from various directions, said barrier wall having an opening through which radiation may pass for reflection from said barrier wall to said sensor.
Claim 27
Dependent Claim
22 words
The system of claim 25 wherein said barrier wall is ovate in shape and wherein said opening is at one end thereof.
Claim 28
Dependent Claim
50 words
The system of claim 25 wherein said barrier wall is formed of a material which fluoresces to produce x-rays when exposed to radiation from said living tumor tissue, and wherein said barrier wall is disposed so that said sensor receives the x-rays produced by the fluorescence of said barrier wall.
Claim 29
Dependent Claim
31 words
The system of claim 1 wherein said radiation detecting means comprises a probe having a handle portion and a needle portion, said needle portion being removably mounted on said handle portion.
Claim 30
Dependent Claim
19 words
The system of claim 28 wherein said radiation detecting means comprises a radiation sensor located in said needle portion.
Claim 31
Independent Claim
169 words
A system for detecting and destroying living tumor tissue within the body of a living being, said system comprising a tumor localizing radiopharmaceutical, a small diameter tissue-penetratable radiation detecting means, and tumor destroying means, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said small diameter tissue-penetratable radiation detecting means being arranged to be inserted into the body of the being with minimal invasion of the being via a percutaneous incision or access port into the tumor tissue and being movable along a path within the tumor tissue for location at various positions therein for detecting said tumor localizing radiation from a plurality of directions and for providing a signal indicative of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached, said tumor destroying means being arranged to be inserted into the body of said being into said living tumor tissue for destroying said living tumor tissue from within it.
Claim 32
Independent Claim
169 words
A system for detecting and destroying living tumor tissue within the body of a living being, said system comprising a tumor localizing radiopharmaceutical, a small diameter tissue-penetratable radiation detecting means, and tumor destroying means, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said small diameter tissue-penetratable radiation detecting means being arranged to be inserted into the body of the being with minimal invasion of the being via a percutaneous incision or access port into the tumor tissue and being movable along a path within the tumor tissue for location at various positions therein for detecting said tumor localizing radiation from a plurality of directions and for providing a signal indicative of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached, said tumor destroying means being arranged to be inserted into the body of said being into said living tumor tissue for destroying said living tumor tissue from within it.
Claim 33
Dependent Claim
34 words
The system of claim 30 wherein said tumor destroying means includes means for carrying pieces of destroyed tumor tissue out of the body of the being for determination of the existence of radioactivity therein.
Claim 34
Dependent Claim
82 words
The system of claim 30 wherein said tumor-localizing radiation comprises photons of different energies, including gamma radiation, X radiation and/or annihilation radiation produced by said radiopharmaceutical, wherein said radiation detecting means is arranged to detect said photons, and wherein system comprises analyzing means utilizing the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical as a reference factor to provide said indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached.
Claim 35
Dependent Claim
74 words
The system of claim 31 wherein said tumor-localizing radiation comprises photons of different energies produced by said radiopharmaceutical, wherein said radiation detecting means is arranged to detect said photons, and wherein system comprises analyzing means utilizing the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical as a reference factor to provide said indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached.
Claim 36
Dependent Claim
55 words
The system of claim 32 wherein said photons of different energies comprise characteristic x-ray photons and full energy gamma-ray photons of a known ratio to each other, and wherein said analyzing means compares said known ratio to the ratio of the photons of said characteristic x-ray photons detected to said full energy gamma-ray photons detected.
Claim 37
Dependent Claim
55 words
The system of claim 33 wherein said photons of different energies comprise characteristic x-ray photons and full energy gamma-ray photons of a known ratio to each other, and wherein said analyzing means compares said known ratio to the ratio of the photons of said characteristic x-ray photons detected to said full energy gamma-ray photons detected.
Claim 38
Dependent Claim
32 words
The system of claim 30 wherein said radiation detecting means comprises an elongated, small diameter probe suitable for percutaneous insertion into the body of the being and having a radiation sensor therein.
Claim 39
Dependent Claim
26 words
The system of claim 36 wherein said tumor destroying means comprises an elongated, small diameter instrument suitable for percutaneous insertion into the body of the being.
Claim 40
Dependent Claim
72 words
The system of claim 37 additionally comprising an elongated lumen suitable for percutaneous insertion into the body of the being and arranged to have said probe inserted therethrough into said living tumor tissue to detect said tumor localizing radiation to provide said signal, said probe being removable from said lumen, said instrument being arranged to be inserted through said lumen to destroy said living tumor tissue from within said living tumor tissue.
Claim 41
Dependent Claim
39 words
The system of claim 38 wherein said probe includes a longitudinal axis and wherein said probe is arranged to be moved to various positions along said axis to position said sensor at various positions within said living tumor tissue.
Claim 42
Dependent Claim
29 words
The system of claim 39 wherein said probe is arranged to be rotated to various angular positions about said axis at any of said various positions of said sensor.
Claim 43
Dependent Claim
29 words
The system of claim 36 wherein said radiation detecting means comprises a radiation sensor selected from the group consisting of a scintillation crystal and a solid state semi-conductor detector.
Claim 44
Dependent Claim
26 words
The system of claim 36 wherein said probe comprises a handle and a needle releasably mounted thereto, and wherein said sensor is mounted in said needle.
Claim 45
Dependent Claim
14 words
The system of claim 36 wherein said sensor has a predetermined field of view.
Claim 46
Dependent Claim
18 words
The system of claim 43 wherein said probe includes collimation means for limiting said predetermined field of view.
Claim 47
Dependent Claim
51 words
The system of claim 36 wherein said probe additionally comprises radiation detection enhancing means comprising a barrier wall disposed adjacent said sensor for blocking radiation to said sensor from various directions, said barrier wall having an opening through which radiation may pass for reflection from said barrier wall to said sensor.
Claim 48
Dependent Claim
22 words
The system of claim 45 wherein said barrier wall is ovate in shape and wherein said opening is at one end thereof.
Claim 49
Dependent Claim
50 words
The system of claim 45 wherein said barrier wall is formed of a material which fluoresces to produce x-rays when exposed to radiation from said living tumor tissue, and wherein said barrier wall is disposed so that said sensor receives the x-rays produced by the fluorescence of said barrier wall.
Claim 50
Dependent Claim
10 words
The system of claim 36 wherein said probe is disposable.
Claim 51
Dependent Claim
83 words
The system of claim 36 wherein said tumor-localizing radiation comprises photons of different energies produced by said radiopharmaceutical, wherein said radiation detecting means is arranged to detect said photons, and wherein system comprises analyzing means utilizing the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical to provide said indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and wherein said probe is disposable and said analyzer is suitable for reuse.
Claim 52
Dependent Claim
157 words
A probe for detecting radiation from living tumor tissue tagged with a radiopharmaceutical within the body of a living being, the radiopharmaceutical producing tumor-localizing radiation from the living tumor tissue, said probe being an elongated member comprising a radiation sensor and radiation detection enhancing means, said probe being arranged to be inserted into the body of the being adjacent the tumor tissue for detecting said tumor localizing radiation from a plurality of directions and for providing a signal indicative of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached, said radiation detection enhancing means comprising a hollow member including barrier wall defining a hollow interior, said barrier wall being disposed adjacent said sensor for blocking radiation to said sensor from various directions, said barrier wall having an opening in communication with said hollow interior through which radiation may pass whereupon the radiation is reflected from said barrier wall to said sensor.
Claim 53
Dependent Claim
157 words
A probe for detecting radiation from living tumor tissue tagged with a radiopharmaceutical within the body of a living being, the radiopharmaceutical producing tumor-localizing radiation from the living tumor tissue, said probe being an elongated member comprising a radiation sensor and radiation detection enhancing means, said probe being arranged to be inserted into the body of the being adjacent the tumor tissue for detecting said tumor localizing radiation from a plurality of directions and for providing a signal indicative of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached, said radiation detection enhancing means comprising a hollow member including barrier wall defining a hollow interior, said barrier wall being disposed adjacent said sensor for blocking radiation to said sensor from various directions, said barrier wall having an opening in communication with said hollow interior through which radiation may pass whereupon the radiation is reflected from said barrier wall to said sensor.
Claim 54
Dependent Claim
22 words
The probe of claim 50 wherein said barrier wall is ovate in shape and wherein said opening is at one end thereof.
Claim 55
Dependent Claim
50 words
The probe of claim 50 wherein said barrier wall is formed of a material which fluoresces to produce x-rays when exposed to radiation from said living tumor tissue, and wherein said barrier wall is disposed so that said sensor receives the x-rays produced by the fluorescence of said barrier wall.
Claim 56
Dependent Claim
50 words
The probe of claim 51 wherein said barrier wall is formed of a material which fluoresces to produce x-rays when exposed to radiation from said living tumor tissue, and wherein said barrier wall is disposed so that said sensor receives the x-rays produced by the fluorescence of said barrier wall.
Claim 57
Dependent Claim
24 words
The probe of claim 50 wherein said sensor is selected from the group consisting of a scintillation crystal and a solid state semi-conductor detector.
Claim 58
Dependent Claim
15 words
The probe of claim 50 wherein said probe comprises a needle having a sharp tip.
Claim 59
Dependent Claim
24 words
The probe of claim 50 wherein said probe comprises a handle and a needle releasably secured thereto, said sensor being located in said needle.
Claim 60
Independent Claim
148 words
A method for determining the three dimensional representation of living tumor tissue within the body of a living being, said method comprising: (a) providing a tumor localizing radiopharmaceutical, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue; (b) providing a small diameter penetratable radiation detecting means; (c) inserting said small diameter penetratable radiation detecting means into the body of the being with minimal invasion of the being percutaneously; (d) moving said small diameter penetratable radiation detecting means along a path within the living tumor tissue for location at various positions within the living tumor tissue; and (e) detecting said tumor localizing radiation from a plurality of directions therein to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 61
Independent Claim
148 words
A method for determining the three dimensional representation of living tumor tissue within the body of a living being, said method comprising: (a) providing a tumor localizing radiopharmaceutical, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue; (b) providing a small diameter penetratable radiation detecting means; (c) inserting said small diameter penetratable radiation detecting means into the body of the being with minimal invasion of the being percutaneously; (d) moving said small diameter penetratable radiation detecting means along a path within the living tumor tissue for location at various positions within the living tumor tissue; and (e) detecting said tumor localizing radiation from a plurality of directions therein to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 62
Dependent Claim
48 words
The method of claim 57 wherein said tumor-localizing radiation comprises photons of different energies including gamma radiation, X radiation and/or annihilation radiation produced by said radiopharmaceutical and wherein said signal is provided by using the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical.
Claim 63
Dependent Claim
55 words
The method of claim 58 wherein said photons of different energies comprise characteristic x-ray photons and full energy gamma-ray photons of a known ratio to each other, and wherein said method comprises comparing said known ratio to the ratio of the photons of said characteristic x-ray photons detected to said full energy gamma-ray photons detected.
Claim 64
Dependent Claim
38 words
The method of claim 59 wherein said penetratable radiation detecting means is an elongated probe suitable for percutaneous introduction into the body of the being, and wherein said probe is introduced percutaneously into the body of the being.
Claim 65
Dependent Claim
42 words
The method of claim 60 wherein said probe has a longitudinal axis, and wherein said method comprises moving said probe along said axis and/or rotating said probe about said longitudinal axis within the living tumor tissue for detecting said tumor localizing radiation.
Claim 66
Dependent Claim
27 words
The method of claim 57 additionally comprising the step of destroying said living tumor tissue from within said living tumor tissue by introducing tumor destroying means therein.
Claim 67
Dependent Claim
27 words
The method of claim 57 additionally comprising the step of destroying said living tumor tissue from within said living tumor tissue by introducing tumor destroying means therein.
Claim 68
Dependent Claim
17 words
The method of claim 63 wherein said tumor destroying means comprises a dose of a necrotizing agent.
Claim 69
Dependent Claim
11 words
The method of claim 64 wherein said necrotizing agent is radioactive.
Claim 70
Dependent Claim
39 words
The method of claim 65 wherein said radioactive agent provides an emission selected from the group consisting of alpha rays, beta rays, gamma rays, x rays, and neutrons and wherein said emission is applied to the living tumor tissue.
Claim 71
Dependent Claim
13 words
The method of claim 64 wherein said necrotizing agent comprises a pharmacologic substance.
Claim 72
Dependent Claim
12 words
The method of claim 64 wherein said necrotizing agent comprises ultrasonic waves.
Claim 73
Dependent Claim
13 words
The method of claim 64 wherein said necrotizing agent comprises a laser beam.
Claim 74
Dependent Claim
11 words
The method of claim 64 wherein said necrotizing agent is thermal.
Claim 75
Dependent Claim
17 words
The method of claim 70 wherein said thermal agent necrotizes the living tumor tissue by heating it.
Claim 76
Dependent Claim
17 words
The method of claim 70 wherein said thermal agent necrotizes the living tumor tissue by cooling it.
Claim 77
Independent Claim
159 words
A method for determining the three dimensional representation of living tumor tissue within the body of a living being, said method comprising: (a) providing a tumor localizing radiopharmaceutical, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said tumor-localizing radiation comprising photons of different energies produced by said radiopharmaceutical; (b) providing a small diameter penetratable radiation detecting means; (c) inserting said small diameter penetratable radiation detecting means into the body of the being with minimal invasion of the being percutaneously; (d) moving said small diameter penetratable radiation detecting means along a path within the living tumor tissue for location at various positions within the living tumor tissue; and (e) detecting said tumor localizing radiation from a plurality of directions to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 78
Independent Claim
159 words
A method for determining the three dimensional representation of living tumor tissue within the body of a living being, said method comprising: (a) providing a tumor localizing radiopharmaceutical, said tumor localizing radiopharmaceutical being attached to the living tumor tissue, whereupon said radiopharmaceutical produces tumor-localizing radiation from the living tumor tissue, said tumor-localizing radiation comprising photons of different energies produced by said radiopharmaceutical; (b) providing a small diameter penetratable radiation detecting means; (c) inserting said small diameter penetratable radiation detecting means into the body of the being with minimal invasion of the being percutaneously; (d) moving said small diameter penetratable radiation detecting means along a path within the living tumor tissue for location at various positions within the living tumor tissue; and (e) detecting said tumor localizing radiation from a plurality of directions to provide an indication of the three dimensional distribution of the living tumor tissue to which said radiopharmaceutical is attached and for providing a signal indicative thereof.
Claim 79
Dependent Claim
46 words
The method of claim 73 wherein said penetratable radiation detecting means is an elongated device having a longitudinal axis, and wherein said penetratable radiation detecting means is caused to be rotated about said longitudinal axis within the living tumor tissue for detecting said tumor localizing radiation.
Claim 80
Dependent Claim
26 words
The method of claim 74 wherein said penetratable radiation detecting means is moved into the living tumor tissue along a path parallel to said longitudinal axis.
Claim 81
Dependent Claim
22 words
The method of claim 73 additionally comprising the step of providing a dose of a necrotizing agent to the living tumor tissue.
Claim 82
Dependent Claim
11 words
The method of claim 76 wherein said necrotizing agent is radioactive.
Claim 83
Dependent Claim
39 words
The method of claim 77 wherein said radioactive agent provides an emission selected from the group consisting of alpha rays, beta rays, gamma rays, x rays, and neutrons and wherein said emission is applied to the living tumor tissue.
Claim 84
Dependent Claim
29 words
The method of claim 73 wherein said method additionally comprises utilizing the known naturally occurring abundance of emitted photons of different energies of said radiopharmaceutical as a reference factor.
Claim 85
Dependent Claim
25 words
The method of claim 78 wherein said emission is a radiation therapy beam provided from either inside or outside of the body of the being.
Claim 86
Dependent Claim
13 words
The method of claim 76 wherein said necrotizing agent comprises a pharmacologic substance.
Claim 87
Dependent Claim
25 words
The method of claim 81 wherein said pharmacologic substance comprises one or more of the group comprising metal powders and colloids of iron and copper.
Claim 88
Dependent Claim
12 words
The method of claim 76 wherein said necrotizing agent comprises ultrasonic waves.
Claim 89
Dependent Claim
22 words
The method of claim 83 wherein said ultrasonic waves are provided from either outside or inside of the body of the being.
Claim 90
Dependent Claim
13 words
The method of claim 76 wherein said necrotizing agent comprises a laser beam.
Claim 91
Dependent Claim
22 words
The method of claim 85 wherein said laser beam is provided from either outside or inside of the body of the being.
Claim 92
Dependent Claim
11 words
The method of claim 76 wherein said necrotizing agent is thermal.
Claim 93
Dependent Claim
18 words
The method of claim 87 wherein said thermal agent necrotizes the living tumor tissue by the heating it.
Claim 94
Dependent Claim
17 words
The method of claim 87 wherein said thermal agent necrotizes the living tumor tissue by cooling it.
Claim 95
Dependent Claim
22 words
The method of claim 87 wherein said thermal agent is provided from either outside or inside of the body of the being.
Claim 96
Dependent Claim
26 words
The method of claim 73 additionally comprising the step of removing at least a portion of the living tumor tissue from the body of the being.
Claim 97
Dependent Claim
22 words
The method of claim 91 wherein the removal of the living tumor tissue from the body of the being is accomplished continuously.
Claim 98
Dependent Claim
16 words
The method of claim 91 additionally comprising the step of examining the removed tissue for radioactivity.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 2001-12-07 | 2002-06-08 | 2002-12-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-12-07 | 2006-06-08 | 2006-12-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-12-07 | 2010-06-08 | 2010-12-08 | $7700.00 | Window Closed / Lapsed |