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US5840300A
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Methods and compositions comprising single chain recombinant antibodies
Assignee: University of Pennsylvania
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Filing: 1995-09-11
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Granted: 1998-11-24
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Expires: 2015-09-11
Abstract
Abstract Methods and compositions for the generation of single chain antibody fragments.
Inventors
- 👤 William V. Williams
- 👤 David B. Weiner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:54
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/08; C07K16/10; C07K16/112; C07K16/114; C07K16/1145; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
61 words
A recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20.
Claim 2
Dependent Claim
61 words
A recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20.
Claim 3
Dependent Claim
13 words
An isolated DNA encoding the recombinant single chain antibody molecule of claim 1.
Claim 4
Independent Claim
81 words
A method of treating a human infected with Human Immunodeficiency Virus type 1 (HIV-1) comprising administering to said human a recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO: 13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20.
Claim 5
Independent Claim
81 words
A method of treating a human infected with Human Immunodeficiency Virus type 1 (HIV-1) comprising administering to said human a recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO: 13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20.
Claim 6
Dependent Claim
3 words
The vector, pMARS8.
Claim 7
Dependent Claim
3 words
The vector, pMARS8.
Claim 8
Independent Claim
90 words
A method of treating a human infected with Human Immunodeficiency Virus comprising administering to said human a pharmaceutical composition that consists essentially of a virus neutralizing recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO: 12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20 providing passive inmunity.
Claim 9
Independent Claim
90 words
A method of treating a human infected with Human Immunodeficiency Virus comprising administering to said human a pharmaceutical composition that consists essentially of a virus neutralizing recombinant single chain antibody molecule selected from the group consisting of SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO: 12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19 and SEQ ID NO:20 providing passive inmunity.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-23 | 2002-05-25 | 2002-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-23 | 2006-05-25 | 2006-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-23 | 2010-05-25 | 2010-11-24 | $7700.00 | Window Closed / Lapsed |