US5811151A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of modifying the surface of a medical device
Assignee: Medtronic Inc
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Filing: 1996-05-31
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Granted: 1998-09-22
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Expires: 2016-05-31
Abstract
Abstract A medical device having a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion; and one or more biomolecules covalently coupled to the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix. The surface graft matrix can also be loaded with a pharmaceutical agent.
Inventors
- 👤 Marc Hendriks
- 👤 Michel Verhoeven
- 👤 Linda L. Cahalan
- 👤 Patrick T. Cahalan
- 👤 Benedicte Fouache
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:23
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/06; A61L33/12; A61L33/128; A61L27/00; A61L27/14; A61L27/22; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L29/00; A61L29/04; A61L29/044; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L31/00; A61L31/04; A61L31/043; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/0041; A61L33/0076; A61L33/0088; A61L2300/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
99 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; and (c) covalently coupling one or more biomolecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix.
Claim 2
Independent Claim
99 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; and (c) covalently coupling one or more biomolecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the biomolecules are located in the outer portion of the surface graft matrix.
Claim 3
Dependent Claim
23 words
A method according to claim 1, wherein the pH of the solutions in steps b and c is no greater than about 5.5.
Claim 4
Dependent Claim
37 words
A method according to claim 1, wherein the step of forming a surface graft matrix further comprises forming the surface graft matrix in a solution having a pH less than the pKa of the surface graft matrix.
Claim 5
Dependent Claim
30 words
A method according to claim 3, further comprising rinsing the formed surface graft matrix in an aqueous solution having a pH greater than the pKa of the surface graft matrix.
Claim 6
Dependent Claim
38 words
A method according to claim 1, wherein the biomolecule is selected from the group consisting of antithrombotic agents, antibacterial agents, anti-inflammatory agents, growth factors, cytokines, naturally occurring or synthetically prepared proteins, peptides, and amino acids, and mixtures thereof.
Claim 7
Dependent Claim
43 words
A method according to claim 1, wherein the surface graft matrix is formed from carboxyl-functional monomers selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, trans-cinnamic acid, crotonic acid, linoleic acid, linolenic acid, maleic acid, sorbic acid, and mixtures thereof.
Claim 8
Dependent Claim
23 words
A method according to claim 1, wherein the surface graft matrix is formed from carboxyl-functional monomers and vinyl monomers having no carboxyl functionality.
Claim 9
Independent Claim
112 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; (c) covalently coupling one or more linker molecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the surface graft matrix; and (d) covalently coupling one or more biomolecules to the linker molecules.
Claim 10
Independent Claim
112 words
A method of modifying the surface of a medical device comprising: (a) forming a surface graft matrix comprising carboxyl-functional groups on the surface of a medical device; (b) treating the surface graft matrix with an aqueous solution having a pH that is less than the pKa of the surface graft matrix; (c) covalently coupling one or more linker molecules to the surface graft matrix in an aqueous solution having a pH that is less than the pKa of the surface graft matrix, wherein a majority of the linker molecules are located in the outer portion of the surface graft matrix; and (d) covalently coupling one or more biomolecules to the linker molecules.
Claim 11
Dependent Claim
23 words
A method according to claim 8, wherein the pH of the solutions in steps b and c is no greater than about 5.5.
Claim 12
Dependent Claim
37 words
A method according to claim 8, wherein the step of forming a surface graft matrix further comprises forming the surface graft matrix in a solution having a pH less than the pKa of the surface graft matrix.
Claim 13
Dependent Claim
30 words
A method according to claim 10, further comprising rinsing the formed surface graft matrix in an aqueous solution having a pH greater than the pKa of the surface graft matrix.
Claim 14
Dependent Claim
38 words
A method according to claim 8, wherein thee biomolecule is selected from the group consisting of antithrombotic agents, antibacterial agents, anti-inflammatory agents, growth factors, cytokines, naturally occurring or synthetically prepared proteins, peptides, and amino acids, and mixtures thereof.
Claim 15
Dependent Claim
43 words
A method according to claim 8, wherein the surface graft matrix is formed from carboxyl-functional monomers selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, trans-cinnamic acid, crotonic acid, linoleic acid, linolenic acid, maleic acid, sorbic acid, and mixtures thereof.
Claim 16
Dependent Claim
23 words
A method according to claim 8, wherein the surface graft matrix is formed from carboxyl-functional monomers and vinyl monomers having no carboxyl functionality.
Claim 17
Independent Claim
66 words
A method of delivering a pharmaceutical agent comprising contacting a body with a medical device comprising a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion in which a majority of one or more biomolecules are coupled, wherein the pharmaceutical agent is located within the surface graft matrix when the device is initially contacted with the body.
Claim 18
Independent Claim
66 words
A method of delivering a pharmaceutical agent comprising contacting a body with a medical device comprising a surface graft matrix comprising carboxyl-functional groups located on the device, the surface graft matrix comprising an outer portion in which a majority of one or more biomolecules are coupled, wherein the pharmaceutical agent is located within the surface graft matrix when the device is initially contacted with the body.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-09-21 | 2002-03-23 | 2002-09-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-09-21 | 2006-03-23 | 2006-09-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-09-21 | 2010-03-23 | 2010-09-22 | $7700.00 | Window Closed / Lapsed |