US5782971A
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US
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Calcium phosphate cements comprising amorophous calcium phosphate
Assignee: KNC NOR Acquisition Sub Inc
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Filing: 1997-03-19
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Granted: 1998-07-21
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Expires: 2017-03-19
Abstract
Abstract Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flowable composition capable of setting in vivo into a solid calcium phosphate mineral product, such as hydroxyapatite, is produced. The subject cement compositions find use in a variety of applications, including the treatment of injured or compromised hard tissue.
Inventors
- 👤 Brent R. Constantz
- 👤 Bryan M. Barr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:55
CPC Classifications
C; C04; C04B; C04B28/00; C04B28/34; A; A61; A61K; A61K6/00; A61K6/50; A61K6/54; A61K6/80; A61K6/831; A61K6/838; A61K6/849; A61K6/864; A61K6/873; A61K6/876; A61L; A61L24/00; A61L24/02; A61L27/00; A61L27/02; A61L27/12; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/58; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; C04B2111/00; C04B2111/00474; C04B2111/00836
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
34 words
A calcium phosphate cement composition comprising: an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8; at least one additional calcium source; and a physiologically acceptable aqueous liquid.
Claim 2
Dependent Claim
34 words
A calcium phosphate cement composition comprising: an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8; at least one additional calcium source; and a physiologically acceptable aqueous liquid.
Claim 3
Dependent Claim
32 words
The calcium phosphate cement composition according to claim 1 wherein said at least one additional calcium source is a calcium source selected from calcium oxide, calcium hydroxide, calcium carbonate or calcium phosphate.
Claim 4
Dependent Claim
36 words
The calcium phosphate cement composition according to claim 2, wherein said calcium phosphate of said at least one additional calcium source is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate and monocalcium phosphate monohydrate.
Claim 5
Dependent Claim
17 words
The calcium phosphate cement composition according to claim 2, wherein said amorphous calcium phosphate is a solid.
Claim 6
Dependent Claim
17 words
The calcium phosphate cement composition according to claim 2, wherein said amorphous calcium phosphate is a gel.
Claim 7
Dependent Claim
23 words
The calcium phosphate cement composition according to claim 5, wherein said gel consists of said amorphous calcium phosphate and said physiologically acceptable liquid.
Claim 8
Dependent Claim
41 words
A calcium phosphate cement composition comprising: (a) a dry component comprising an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8 and at least one additional calcium phosphate; and (b) a physiologically acceptable aqueous lubricant.
Claim 9
Dependent Claim
41 words
A calcium phosphate cement composition comprising: (a) a dry component comprising an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8 and at least one additional calcium phosphate; and (b) a physiologically acceptable aqueous lubricant.
Claim 10
Dependent Claim
32 words
The calcium phosphate cement composition according to claim 7, wherein said at least one additional calcium phosphate is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate and monocalcium phosphate monohydrate.
Claim 11
Dependent Claim
17 words
The calcium phosphate cement composition according to claim 8, wherein said cement further comprises an organic polymer.
Claim 12
Dependent Claim
16 words
The calcium phosphate cement composition according to claim 9, wherein said organic polymer is a protein.
Claim 13
Independent Claim
61 words
A method for preparing a remodelable calcium phosphate mineral, said method comprising: combining (a) an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8, (b) at least one additional calcium source and (c) a physiologically acceptable aqueous lubricant to produce a flowable composition; and allowing said flowable composition to set into said calcium phosphate mineral.
Claim 14
Independent Claim
61 words
A method for preparing a remodelable calcium phosphate mineral, said method comprising: combining (a) an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8, (b) at least one additional calcium source and (c) a physiologically acceptable aqueous lubricant to produce a flowable composition; and allowing said flowable composition to set into said calcium phosphate mineral.
Claim 15
Dependent Claim
30 words
The method according to claim 11, wherein said at least one additional calcium source is selected from the group consisting of calcium oxide, calcium hydroxide, calcium carbonate and calcium phosphate.
Claim 16
Dependent Claim
33 words
The method according to claim 12, wherein said calcium phosphate of said at least one additional calcium source is selected from the group consisting of telracailcium phosphate, tricalcium phosphate and monocalcium phosphate monohydrate.
Claim 17
Dependent Claim
14 words
The method according to claim 11, wherein said calcium phosphate mineral is an apatite.
Claim 18
Dependent Claim
11 words
The method according to claim 14, wherein said apatite is hydroxyapatite.
Claim 19
Dependent Claim
13 words
The method according to claim 15, wherein said hydroxyapatite is calcium deficient hydroxyapatite.
Claim 20
Independent Claim
61 words
A method for preparing a remodelable hydroxyapatite, said method comprising: combining (a) a dry component comprising an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8 and at least one additional calcium phosphate with (b) physiologically acceptable aqueous lubricant to produce a flowable composition; and allowing said flowable composition to set into said remodelable hydroxyapatite.
Claim 21
Independent Claim
61 words
A method for preparing a remodelable hydroxyapatite, said method comprising: combining (a) a dry component comprising an amorphous calcium phosphate having a calcium to phosphate molar ratio of about 1.6 to 1.8 and at least one additional calcium phosphate with (b) physiologically acceptable aqueous lubricant to produce a flowable composition; and allowing said flowable composition to set into said remodelable hydroxyapatite.
Claim 22
Dependent Claim
14 words
The method according to claim 17, wherein said remodelable hydroxyapatite is calcium deficient hydroxyapatite.
Claim 23
Dependent Claim
17 words
The method according to claim 18, wherein said at least one additional calcium phosphate is tetracalcium phosphate.
Claim 24
Dependent Claim
17 words
The method according to claim 18, wherein said at least one additional calcium phosphate is tricalcium phosphate.
Claim 25
Dependent Claim
9 words
A kit comprising the cement according to claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-07-20 | 2002-01-19 | 2002-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-07-20 | 2006-01-19 | 2006-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-07-20 | 2010-01-19 | 2010-07-21 | $7700.00 | Window Closed / Lapsed |