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US5741211A
Expired / Lapsed
US
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System and method for continuous monitoring of diabetes-related blood constituents
Assignee: Medtronic Inc
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Filing: 1995-10-26
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Granted: 1998-04-21
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Expires: 2015-10-26
Abstract
Abstract A system and method for sensing and providing an indication of one or more diabetes-related blood constituents of a patient, the system being based upon an ECG sensor which processes patient ECG signals, either surface, or intracardiac or epicardial, for determining a measure of a blood constituent such as insulin or glucose, or both insulin and glucose. The system has processing capability for correlating selected parameters of the ECG signal with patient blood insulin or blood glucose, to provide the insulin or glucose level. Additionally, the system is provided with input capability for enabling the patient to input data such as the time of meal intake, which is representative of glucose intake, which data is incorporated in making a determination of patient insulin need. The system can be in a first external wearable embodiment, or in a second implantable embodiment which utilizes a pacing-type lead for picking up intracardiac or epicardial signals. In either the wearable or implantable embodiment, the output response may be simply an indication of patient insulin and/or glucose need provided by an external display, and may also include automatic control of insulin injection to the patient.
Inventors
- 👤 Alexis C. M. Renirie
- 👤 Richard Houben
- 👤 Frank van Leeuwen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:12
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/14532; Y; Y10; Y10S; Y10S128/00; Y10S128/92
Claims Analysis
Total Claims: 49
Claim 1
Independent Claim
74 words
System apparatus for providing an indication of at least patient blood insulin, comprising: ECG sensor means for obtaining signals representative of the patient ECG, signal processing means for processing said ECG signals to provide first parameter data indicative of the patient's blood insulin level, wherein the signal processing means include means for comparing the sensed ECG signals against a reference value, and response means for providing a response as a function of said data.
Claim 2
Dependent Claim
74 words
System apparatus for providing an indication of at least patient blood insulin, comprising: ECG sensor means for obtaining signals representative of the patient ECG, signal processing means for processing said ECG signals to provide first parameter data indicative of the patient's blood insulin level, wherein the signal processing means include means for comparing the sensed ECG signals against a reference value, and response means for providing a response as a function of said data.
Claim 3
Dependent Claim
24 words
The system apparatus as described in claim 1, wherein said response means comprises means for outputting an indication of the patient's blood insulin level.
Claim 4
Dependent Claim
37 words
The system apparatus as described in claim 1, wherein said system apparatus is implantable in said patient and said response means comprises pump means for injecting insulin into said patient as a function of said insulin data.
Claim 5
Dependent Claim
51 words
The system apparatus as described in claim 1, comprising a wearable housing for housing said apparatus and adapted to be worn by a patient, and wherein said response means comprises output means for providing an output signal receivable by said patient, said output signal being representative of the patient's insulin level.
Claim 6
Dependent Claim
34 words
The system apparatus as described in claim 1, wherein said signal processing means further comprises glucose means for processing said ECG signals and obtaining second parameter data indicative of the patient blood glucose level.
Claim 7
Dependent Claim
42 words
The system apparatus as described in claim 5, wherein said signal processing means further comprises analyzing means for analyzing said insulin and glucose data, and additional response means for providing a response as a function of said analyzed insulin and glucose data.
Claim 8
Dependent Claim
20 words
The system apparatus as described in claim 1, comprising keyboard input means for inputting data representative of patient glucose intake.
Claim 9
Independent Claim
71 words
A system for providing an indication of blood insulin level of a patient, comprising ECG sensor means for sensing ECG signals of said patient, processing means for processing said ECG signals and obtaining therefrom a measure of patient blood insulin, wherein the processing means include means for comparing the sensed ECG against a reference value, and output means responsive to said insulin measure for outputting an indication of patient insulin level.
Claim 10
Independent Claim
71 words
A system for providing an indication of blood insulin level of a patient, comprising ECG sensor means for sensing ECG signals of said patient, processing means for processing said ECG signals and obtaining therefrom a measure of patient blood insulin, wherein the processing means include means for comparing the sensed ECG against a reference value, and output means responsive to said insulin measure for outputting an indication of patient insulin level.
Claim 11
Dependent Claim
18 words
The system as described in claim 8, comprising an implantable housing for housing said system within said patient.
Claim 12
Dependent Claim
31 words
The system as described in claim 8, wherein said signal processing means comprises parameter means for separating out predetermined parameters of said patient ECG which correlate to patient blood insulin level.
Claim 13
Dependent Claim
43 words
The system as described in claim 8, comprising storage means for storing patient blood insulin levels, and wherein said signal processing means further comprises extrapolation means for extrapolating anticipated time of insulin need as a function of said stored patient blood insulin levels.
Claim 14
Dependent Claim
26 words
The system as described in claim 8, further comprising second processing means for processing said ECG signals and obtaining therefrom an indication of patient blood glucose.
Claim 15
Dependent Claim
38 words
The system as described in claim 12, further comprising delivery means for delivering insulin to the patient, and control means for controlling said delivery means to provide indicated insulin in response to indicated patient insulin and glucose levels.
Claim 16
Independent Claim
91 words
A system for determining insulin need of a diabetic patient, comprising ECG sensing means for sensing the patient ECG and deriving therefrom an indication of patient blood insulin level, glucose input means for inputting data indicative of patient glucose intake, processing means for determining patient insulin need as a function of said indicated blood insulin level and said glucose intake data, wherein the processing means include means for comparing said indicated blood insulin level against a reference value, and response means for outputting an indication of said determined patient insulin need.
Claim 17
Independent Claim
91 words
A system for determining insulin need of a diabetic patient, comprising ECG sensing means for sensing the patient ECG and deriving therefrom an indication of patient blood insulin level, glucose input means for inputting data indicative of patient glucose intake, processing means for determining patient insulin need as a function of said indicated blood insulin level and said glucose intake data, wherein the processing means include means for comparing said indicated blood insulin level against a reference value, and response means for outputting an indication of said determined patient insulin need.
Claim 18
Dependent Claim
26 words
The system as described in claim 14, wherein said ECG sensing means comprises first processing means for processing ECG signals and deriving therefrom selected parameter data.
Claim 19
Dependent Claim
36 words
The system as described in claim 15, wherein said ECG sensing means comprises second processing means for determining time variations of selected ECG parameters and for calculating anticipated insulin need as a function of said variations.
Claim 20
Dependent Claim
27 words
The system as described in claim 14, wherein said glucose input means comprises an input terminal adapted to enable said patient to enter said glucose intake data.
Claim 21
Dependent Claim
25 words
The system as described in claim 17, wherein said input means comprises time means for storing data representative of the time of patient glucose intake.
Claim 22
Dependent Claim
46 words
The system as described in claim 14, wherein said processing means comprises glucose variation means for calculating anticipated glucose variation as a function of said glucose intake data, and wherein said response means comprises comparing means for comparing anticipated glucose variation with measured patient insulin level.
Claim 23
Dependent Claim
44 words
The system as described in claim 14, comprising second processing means for processing said ECG signals to obtain a measure of patient glucose, and wherein said response means comprises dual parameter response means for responding as a function of determined insulin and glucose levels.
Claim 24
Independent Claim
103 words
A system for sensing one or more diabetes-related blood constituents of a patient, comprising an implantable apparatus and an external apparatus, said implantable apparatus comprising sensor means for continuously sensing ECG signals from said patient; processing means for continuously processing said ECG signals and obtaining therefrom data indicating the level of at least one selected blood constituent, wherein the processing means include means for comparing the sensed ECG signals against a reference value; and transfer means for transferring said data to said external apparatus, and said external apparatus comprising indicator means for indicating said patient blood constituent level based upon said transferred data.
Claim 25
Independent Claim
103 words
A system for sensing one or more diabetes-related blood constituents of a patient, comprising an implantable apparatus and an external apparatus, said implantable apparatus comprising sensor means for continuously sensing ECG signals from said patient; processing means for continuously processing said ECG signals and obtaining therefrom data indicating the level of at least one selected blood constituent, wherein the processing means include means for comparing the sensed ECG signals against a reference value; and transfer means for transferring said data to said external apparatus, and said external apparatus comprising indicator means for indicating said patient blood constituent level based upon said transferred data.
Claim 26
Dependent Claim
39 words
The system as described in claim 21, wherein said at least one selected blood constituent is blood insulin, and said data is insulin data, and said indicating means comprises display means for displaying a measure of patient blood insulin.
Claim 27
Dependent Claim
40 words
The system as described in claim 22, comprising external data transfer means for transferring data from said external apparatus to said implanted apparatus, and wherein said implanted apparatus comprises receiving means for receiving said data transferred from said external apparatus.
Claim 28
Dependent Claim
22 words
The system as described in claim 23, wherein said external transfer means comprises means for transferring data representative of patient glucose intake.
Claim 29
Dependent Claim
42 words
The system as described in claim 24, wherein said implanted apparatus comprises processing means for processing said insulin data and said glucose intake data, and response means for delivering insulin to said patient based on said insulin data and said glucose data.
Claim 30
Dependent Claim
23 words
The system as described in claim 25, wherein said response means comprises an insulin pump for injecting insulin directly into said patient's body.
Claim 31
Dependent Claim
48 words
The system as described in claim 23, wherein said external apparatus comprises input means for inputting data representative of patient glucose intake and transfer means for transferring said glucose intake data to said implantable apparatus, said implantable apparatus having receiving means for receiving said transferred glucose intake data.
Claim 32
Dependent Claim
35 words
The system as described in claim 21, wherein said blood constituent is glucose and said data is blood glucose data, and said indicating means comprises display means for displaying a measure of patient blood glucose.
Claim 33
Independent Claim
26 words
The system as described in claims 28, comprising validity means for storing data indicative of whether said ECG signals correlate with blood glucose for said patient.
Claim 34
Dependent Claim
18 words
The system as described in claim 21, wherein said sensor means comprises means for sensing patient intracardiac signals.
Claim 35
Dependent Claim
18 words
The system as described in claim 21, wherein said sensor means comprises means for sensing patient epicardial signals.
Claim 36
Dependent Claim
23 words
The system as described in claim 21, wherein said processing means comprises VCG means for deriving the patient VCG from said ECG signals.
Claim 37
Independent Claim
144 words
A system for continuously determining a measure of at least one diabetes-related blood constituent of a patient, said constituent selected from the group of blood insulin and blood glucose, comprising: sense means for continuously sensing patient ECG signals, the ECG having a QRS portion and a T wave portion; programmable means for storing data reflective of preselected ECG parameters corresponding to a selected one of said blood constituents; first signal processing means for substantially continuously extracting from said ECG signals portions representative of said ECG parameters; second signal processing means for processing said extracted signal portions and obtaining data therefrom which correlates with said selected constituent; and third signal processing means for continuously determining a measure of said selected constituent as a function of said obtained data wherein said third signal processing means include means for comparing said obtained data against a reference value.
Claim 38
Independent Claim
144 words
A system for continuously determining a measure of at least one diabetes-related blood constituent of a patient, said constituent selected from the group of blood insulin and blood glucose, comprising: sense means for continuously sensing patient ECG signals, the ECG having a QRS portion and a T wave portion; programmable means for storing data reflective of preselected ECG parameters corresponding to a selected one of said blood constituents; first signal processing means for substantially continuously extracting from said ECG signals portions representative of said ECG parameters; second signal processing means for processing said extracted signal portions and obtaining data therefrom which correlates with said selected constituent; and third signal processing means for continuously determining a measure of said selected constituent as a function of said obtained data wherein said third signal processing means include means for comparing said obtained data against a reference value.
Claim 39
Dependent Claim
25 words
The system as described in claim 33, comprising a housing for containing said system whereby said system is adapted to be wearable by a patient.
Claim 40
Dependent Claim
15 words
The system as described in claim 33, comprising external means for programming said ECG parameters.
Claim 41
Dependent Claim
14 words
The system as described in claim 33, wherein said sense means comprises subcutaneous electrodes.
Claim 42
Dependent Claim
28 words
The system as described in claim 33, wherein said first signal processing means comprises averaging means for beat-to-beat averaging over a predetermined number of consecutive patient cardiac beats.
Claim 43
Dependent Claim
40 words
The system as described in claim 33, wherein said second signal processing means comprises means for determining from said extracted signals a measure of at least one of the QRS and the T wave portions of said patient ECG signals.
Claim 44
Dependent Claim
30 words
The system as described in claim 38, wherein said determining means comprises means for getting a measure of a RMS value of both said QRS and the T wave portions.
Claim 45
Dependent Claim
19 words
The system as described in claim 33, wherein said sense means has means for sensing intracardiac patient ECG signals.
Claim 46
Dependent Claim
37 words
The system as described in claim 38, further comprising means for storing basal values of preselected ECG parameters, and wherein said determining means comprises statistical means for comprising said determined parameter values with corresponding stored basal values.
Claim 47
Dependent Claim
31 words
The system as described in claim 33, wherein said at least one diabetes-related constituent is patient blood insulin, and comprising output means for providing an output representative of patient blood insulin.
Claim 48
Dependent Claim
31 words
The system as described in claim 33, wherein said at least one diabetes-related constituent is patient blood glucose, and comprising output means for providing an output representative of patient blood glucose.
Claim 49
Dependent Claim
29 words
The system as described in claim 33, wherein said at least one diabetes-related constituent is blood glucose, and further comprising validity means for enabling determination of patient blood glucose.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-04-20 | 2001-10-20 | 2002-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-04-20 | 2005-10-20 | 2006-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-04-20 | 2009-10-20 | 2010-04-21 | $7700.00 | Window Closed / Lapsed |